INT14114

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2008
Negated 0
Speculated 4
Reported most in Abstract
Documents 30
Total Number 34
Disease Relevance 4.24
Pain Relevance 18.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
spinal 5
brain 4
dorsal 1
medulla 1
spinal cord 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 79 100.00 Very High Very High Very High
agonist 39 100.00 Very High Very High Very High
antagonist 24 100.00 Very High Very High Very High
Cholecystokinin 14 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
anesthesia 2 99.92 Very High Very High Very High
analgesia 5 99.88 Very High Very High Very High
Locus ceruleus 4 99.88 Very High Very High Very High
opioid receptor 4 99.72 Very High Very High Very High
opiate 12 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 7 99.84 Very High Very High Very High
Bordatella Infection 2 99.76 Very High Very High Very High
Hypotension 12 99.60 Very High Very High Very High
Cv General 4 Under Development 2 99.24 Very High Very High Very High
Drug Dependence 2 99.20 Very High Very High Very High
Brain Hemorrhage 3 98.36 Very High Very High Very High
Hypertension 10 98.06 Very High Very High Very High
Pain 5 97.64 Very High Very High Very High
Sprains And Strains 2 95.40 Very High Very High Very High
Cv Unclassified Under Development 8 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain alpha 2-adrenergic receptor binding during incomplete cerebral ischemia in the rat.
Brain alpha 2-adrenergic Binding (binding) of in Brain associated with cv general 4 under development and ischemia
1) Confidence 0.48 Published 1993 Journal Anesth. Analg. Section Title Doc Link 8380957 Disease Relevance 0.48 Pain Relevance 0.70
We examined the effect of chronic opiate treatment on the alpha 2-adrenergic receptor binding of both the agonist [3H]clonidine and the antagonist [3H]yohimbine in the cerebral cortex and kidney of rats.
alpha 2-adrenergic Spec (examined) Binding (binding) of in kidney associated with antagonist, agonist, opiate, cerebral cortex and clonidine
2) Confidence 0.48 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6317412 Disease Relevance 0 Pain Relevance 0.60
Clinical and basic science studies suggest that spinal alpha-2-adrenergic receptor agonists and local anesthetics produce analgesia, but interaction between alpha-2-adrenergic receptor agonists and local anesthetics in the persistent pain model has not been examined.
alpha-2-adrenergic Binding (interaction) of in spinal associated with pain, lasting pain, agonist, analgesia and local anesthetic
3) Confidence 0.47 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11226110 Disease Relevance 0.10 Pain Relevance 1.25
The interactions of the anticoagulant Heparin with the alpha-2-adrenoceptor in rat brain cortex membranes were investigated.
alpha-2-adrenoceptor Binding (interactions) of in brain
4) Confidence 0.40 Published 1988 Journal J. Recept. Res. Section Abstract Doc Link 2839678 Disease Relevance 0 Pain Relevance 0.22
The ability of the alpha 2-agonists clonidine, B-HT920 (6-allyl-2-amino-5,6,7,8-tetrohydro-4H-thiazolo-[4,5-d]-azepine) and guanfacine to improve memory in aged monkeys has been related to their affinity to bind at a proposed rauwolscine-insensitive (Ri) subtype of alpha 2-adrenergic receptor, while their hypotensive and sedating effects have been related to affinity at a rauwolscine-sensitive site (Rs) (Arnsten et al., 1988).
2-adrenergic Binding (bind) of associated with hypotension, agonist and clonidine
5) Confidence 0.39 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1686301 Disease Relevance 0.17 Pain Relevance 0.25
Brain alpha 2-adrenergic receptor binding was measured using [3H]-clonidine in each of four treatment conditions: 1, unanesthetized; 2, anesthetized (fentanyl/N2O, halothane, or isoflurane): 3, anesthetized with ischemia; 4, after 4 h recovery from ischemia.
Brain alpha 2-adrenergic Binding (binding) of in Brain associated with ischemia, isoflurane, halothane and clonidine
6) Confidence 0.37 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8380957 Disease Relevance 0.51 Pain Relevance 0.72
Previously, we have shown that dexmedetomidine and clonidine act upon spinal alpha 2 adrenoceptor, which appeared distinguishable from that acted upon by ST-91.
alpha 2 adrenoceptor Spec (appeared) Binding (act) of in spinal associated with clonidine
7) Confidence 0.37 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093729 Disease Relevance 0 Pain Relevance 0.61
Hypotensive action of clonidine analogues correlates with binding affinity at imidazole and not alpha-2-adrenergic receptors in the rostral ventrolateral medulla.
alpha-2-adrenergic Binding (affinity) of in medulla associated with rostral ventrolateral medulla, hypotension and clonidine
8) Confidence 0.37 Published 1988 Journal J Hypertens Suppl Section Title Doc Link 2853758 Disease Relevance 0.24 Pain Relevance 0.71
The alpha-2 adrenoceptor agonists clonidine, UK14, 304 and rilmenidine, which bind to the imidazoline preferring receptor, and guanabenz which does not, dose-dependently substituted for (i.e. > 80% total responding was clonidine associated) the clonidine-induced cue in doses up to 0.02, 0.16, 1.25 and 0.32 mg kg-1, respectively.
alpha-2 adrenoceptor Binding (bind) of associated with agonist and clonidine
9) Confidence 0.36 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870887 Disease Relevance 0 Pain Relevance 0.82
The present study investigated the effects of acute and repeated tramadol administration on the binding of [3H]RX 821002, a selective alpha2-adrenergic receptor ligand, in the rat brain.
alpha2-adrenergic Binding (binding) of in brain associated with tramadol
10) Confidence 0.35 Published 2004 Journal Brain Res. Section Abstract Doc Link 15246863 Disease Relevance 0.09 Pain Relevance 0.71
In the course of isolation, CDS was shown to be neither the endogenous neurotransmitter (-)norepinephrine (NE) nor the guanyl nucleotide GTP which lowers the specific binding of alpha 2-agonists to the alpha 2-adrenergic receptors.
alpha 2-adrenergic Binding (binding) of associated with neurotransmitter and agonist
11) Confidence 0.35 Published 1984 Journal FEBS Lett. Section Abstract Doc Link 6327389 Disease Relevance 0 Pain Relevance 0.41
Neither haloperidol nor olanzapine (despite its atypical features) shows appreciable affinity for the alpha2-adrenoceptor.
alpha2-adrenoceptor Binding (affinity) of
12) Confidence 0.35 Published 2003 Journal Behav Pharmacol Section Abstract Doc Link 12838036 Disease Relevance 0.14 Pain Relevance 0.37
There was no alteration in alpha 2 adrenergic receptor binding.
alpha 2 adrenergic receptor Binding (binding) of
13) Confidence 0.35 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3031275 Disease Relevance 0 Pain Relevance 0.92
The binding of alpha2-adrenergic receptor ligands to nicotinic receptors might affect the intraspinal release of acetylcholine.
alpha2-adrenergic Binding (ligands) of
14) Confidence 0.34 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15078339 Disease Relevance 0 Pain Relevance 0.41
In renal membranes from 1K-1C hypertensive rats, [3H] idazoxan binding (imidazoline-preferring site antagonist) was decreased, whereas the binding of [3H] rauwolscine (alpha-2 adrenoceptor antagonist) was unaltered.
alpha-2 adrenoceptor Binding (binding) of associated with antagonist and hypertension
15) Confidence 0.31 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7903388 Disease Relevance 0.56 Pain Relevance 0.51
Effect of agmatine on spinal nociceptive reflexes: lack of interaction with alpha2-adrenoceptor or mu-opioid receptor mechanisms.
alpha2-adrenoceptor Binding (interaction) of in spinal associated with nociception, nociceptor and opioid receptor
16) Confidence 0.31 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9274971 Disease Relevance 0.28 Pain Relevance 0.29
AF64-A did not reduce alpha2-adrenergic ligand binding in dorsal lumbar cord.
alpha2-adrenergic Binding (binding) of in dorsal
17) Confidence 0.31 Published 2001 Journal Anesthesiology Section Body Doc Link 11465600 Disease Relevance 0.07 Pain Relevance 0
The results indicate that the interaction between alpha 2-adrenoceptor-mediated pressor responses and calcium entry blockers, such as verapamil, is a stereoselective event.
2-adrenoceptor-mediated Binding (interaction) of
18) Confidence 0.30 Published 1983 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6137534 Disease Relevance 0.13 Pain Relevance 0.17
Since opioid and alpha2-adrenergic mechanisms closely interact in nociception and substance abuse, a comparative study of the endogenous alpha2-adrenergic system in both inbred strains is of interest.
alpha2-adrenergic Binding (interact) of associated with nociception, drug abuse, sprains and strains and opioid
19) Confidence 0.27 Published 2006 Journal Life Sci. Section Abstract Doc Link 16139312 Disease Relevance 0.37 Pain Relevance 0.45
These results suggest that neurons in the LC that possess an alpha2 adrenergic receptor on the membrane surface exert a tonic inhibitory effect on IX expiratory activity in neonatal rat brainstem-spinal cord preparations.
alpha2 adrenergic receptor Binding (possess) of in spinal cord associated with medulla, locus ceruleus and spinal cord
20) Confidence 0.27 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18053604 Disease Relevance 0 Pain Relevance 0.81

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