INT141146

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 8.61
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
plasma 2
articular cartilage 2
finger 1
TMJ 1
Mmp13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 182 100.00 Very High Very High Very High
substance P 3 99.92 Very High Very High Very High
Snapping jaw 16 99.32 Very High Very High Very High
Central nervous system 20 98.90 Very High Very High Very High
fibrosis 64 96.72 Very High Very High Very High
Inflammation 179 94.84 High High
chemokine 16 89.60 High High
Osteoarthritis 123 89.32 High High
cytokine 112 87.84 High High
Neuropeptide 1 77.44 Quite High
Disease Link Frequency Relevance Heat
Stroke 6 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 16 99.32 Very High Very High Very High
Vasculitis 1 99.22 Very High Very High Very High
Hypoxia 77 99.02 Very High Very High Very High
Injury 60 98.72 Very High Very High Very High
Osteoarthritis 140 98.24 Very High Very High Very High
Cancer 45 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.80 Very High Very High Very High
Fibrosis 44 96.72 Very High Very High Very High
INFLAMMATION 200 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMPs are not only involved in tumor invasion but can also be a sign of CNS vascular injury as indicated by an increase in plasma levels of MMP9 and MMP13 in stroke patients [94].
Gene_expression (levels) of MMP13 in plasma associated with stroke, cancer, metalloproteinase, central nervous system and vasculitis
1) Confidence 0.38 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2556333 Disease Relevance 1.39 Pain Relevance 0.35
Expression of a few key genes, such as collagen type II and MMP-13, appeared not to be protected; however, Tables 3 and 4 show that expression of these genes was also downregulated and enhanced, respectively, by prior incubation with glucosamine alone.
Gene_expression (Expression) of MMP-13
2) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.30 Pain Relevance 0.24
MMP-13, the interstitial collagenase in rodents, is a specific protease capable of degrading fibrillar collagen (3).
Gene_expression (protease) of MMP-13
3) Confidence 0.19 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.56 Pain Relevance 0.40
BMA resulted in decreased COMP and increased MMP-3 and MMP-13 gene expression.
Gene_expression (expression) of MMP-13
4) Confidence 0.18 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.11
Expression of two of the exceptions, MMP-13 and ring finger protein 28, was found similarly enhanced by glucosamine alone.
Gene_expression (Expression) of MMP-13 in finger
5) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.14 Pain Relevance 0.12
TAA slightly increased MT1-MMP and decreased MMP-13 levels, but not significantly.
Gene_expression (levels) of MMP-13
6) Confidence 0.17 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.44 Pain Relevance 0.38
The anti-catabolic effect of OP-1 was documented by reduced immunostaining for aggrecanase, MMP-13, substance P, TNF-alpha, and IL-1beta.
Gene_expression (immunostaining) of MMP-13 associated with substance p
7) Confidence 0.17 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17205567 Disease Relevance 0.55 Pain Relevance 0.39
Expression of a few key genes, such as collagen type II and MMP-13, appeared not to be protected; however, Tables 3 and 4 show that expression of these genes was also downregulated and enhanced, respectively, by prior incubation with glucosamine alone.
Gene_expression (expression) of MMP-13
8) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.30 Pain Relevance 0.23
Lyophilized PP and PRP resulted in increased COL1A1:COL3A1 ratio, increased COMP, and decreased MMP-13 expression.
Gene_expression (expression) of MMP-13 in PRP
9) Confidence 0.16 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.10
In our report, we found that MMP-3 mRNA expression and MMP (-1, -2, -3, -7, and -9) activities were decreased, while a slight downregulation of MMP-13 mRNA expression or activity was observed.
Gene_expression (expression) of MMP-13 mRNA associated with metalloproteinase
10) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0.08 Pain Relevance 0.48
Curiously, MMP-13 (also termed collagenase-3) – a protease specific for type II collagen, a primary ECM component of articular cartilage – was among the few genes whose expression was strongly stimulated (in this case approximately eightfold) by glucosamine.
Gene_expression (expression) of MMP-13 in articular cartilage
11) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.07 Pain Relevance 0.04
Primers for collagen type I, type III, TIMP 1, 2, and 3, and matrix metalloproteinase 13 (MMP-13) were synthesized on site; sequences were as reported previously in [36, 38].
Gene_expression (synthesized) of MMP-13 associated with metalloproteinase
12) Confidence 0.10 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.12 Pain Relevance 0.17
The GLP-2 ligands showed no effects on mRNA levels for the TIMPs, except for an increase under hypoxic conditions with GLP-2 MMB (data not shown), and MMP-13 expression was not changed but trended downward (Figure 6).
Gene_expression (expression) of MMP-13 associated with hypoxia
13) Confidence 0.10 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.83 Pain Relevance 0.06
On the basis of these previous studies, we discuss the need for studies on the effect of statin treatment on the serum levels of MMP-13 and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels in hypercholesterolemic patients.
Gene_expression (levels) of MMP-13 associated with metalloproteinase
14) Confidence 0.07 Published 2008 Journal J Cardiovasc Med (Hagerstown) Section Abstract Doc Link 19001938 Disease Relevance 0.81 Pain Relevance 0.40
MMP-13, MMP-3, and TIMP-1 were expressed strongly in the TMJ soon after injury; MMP-13 became gradually weakened, and MMP-3 strengthened later.
Gene_expression (expressed) of MMP-13 in TMJ associated with snapping jaw and injury
15) Confidence 0.07 Published 2008 Journal Br J Oral Maxillofac Surg Section Abstract Doc Link 18164790 Disease Relevance 1.14 Pain Relevance 0.77
activation can also reduce expression of MMP-13 and MMP-1 by interfering with AP-1 activation [94-96].
Gene_expression (expression) of MMP-13
16) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.04
However, the effect of statin treatment on the serum levels of MMP-13, which has a critical role in the initiation of collagen degradation, is unknown.
Gene_expression (levels) of MMP-13
17) Confidence 0.06 Published 2008 Journal J Cardiovasc Med (Hagerstown) Section Abstract Doc Link 19001938 Disease Relevance 1.02 Pain Relevance 0.43
By increasing the expression of matrix metalloproteinases (MMP-3, MMP-9, MMP-10, MMP-12, and MMP-13) while inhibiting the expression of genes encoding essential components of the ECM (such as collagen type II and aggrecan-1), the elevated IL-1?
Gene_expression (expression) of MMP-13 associated with metalloproteinase
18) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.20 Pain Relevance 0.30
Our aim was to examine the change in expression of matrix metalloproteinases (MMP-13), matrix metalloproteinases-3 (MMP-3), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the articular cartilage of goats with experimentally-induced osteoarthrosis of the temporomandibular joint (TMJ) at various times.
Spec (examine) Gene_expression (expression) of MMP-13 in articular cartilage associated with snapping jaw, metalloproteinase and osteoarthritis
19) Confidence 0.05 Published 2008 Journal Br J Oral Maxillofac Surg Section Abstract Doc Link 18164790 Disease Relevance 0.66 Pain Relevance 0.52

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