INT141147

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.37
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
PRP 2
Mmp13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 99 100.00 Very High Very High Very High
substance P 3 99.92 Very High Very High Very High
fibrosis 34 97.04 Very High Very High Very High
Inflammation 31 88.64 High High
Osteoarthritis 31 86.92 High High
chemokine 3 84.04 Quite High
cytokine 15 83.56 Quite High
Neuropeptide 1 77.44 Quite High
Pain 5 74.08 Quite High
agonist 57 65.04 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 23 97.04 Very High Very High Very High
INFLAMMATION 34 88.64 High High
Osteoarthritis 36 86.92 High High
Necrosis 2 82.44 Quite High
Cancer 2 82.08 Quite High
Intervertebral Disk Degeneration 3 80.96 Quite High
Arthritis 15 77.12 Quite High
Pain 4 74.08 Quite High
Injury 10 39.40 Quite Low
Wound Healing 2 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TAA slightly increased MT1-MMP and decreased MMP-13 levels, but not significantly.
Negative_regulation (decreased) of Gene_expression (levels) of MMP-13
1) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.44 Pain Relevance 0.38
Expression of a few key genes, such as collagen type II and MMP-13, appeared not to be protected; however, Tables 3 and 4 show that expression of these genes was also downregulated and enhanced, respectively, by prior incubation with glucosamine alone.
Negative_regulation (downregulated) of Gene_expression (expression) of MMP-13
2) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.30 Pain Relevance 0.24
The anti-catabolic effect of OP-1 was documented by reduced immunostaining for aggrecanase, MMP-13, substance P, TNF-alpha, and IL-1beta.
Negative_regulation (reduced) of Gene_expression (immunostaining) of MMP-13 associated with substance p
3) Confidence 0.11 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17205567 Disease Relevance 0.55 Pain Relevance 0.39
In our report, we found that MMP-3 mRNA expression and MMP (-1, -2, -3, -7, and -9) activities were decreased, while a slight downregulation of MMP-13 mRNA expression or activity was observed.
Negative_regulation (downregulation) of Gene_expression (expression) of MMP-13 mRNA associated with metalloproteinase
4) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0.08 Pain Relevance 0.48
Lyophilized PP and PRP resulted in increased COL1A1:COL3A1 ratio, increased COMP, and decreased MMP-13 expression.
Negative_regulation (decreased) of Gene_expression (expression) of MMP-13 in PRP
5) Confidence 0.09 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.10

General Comments

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