INT141148

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 33
Disease Relevance 14.34
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (BMP7) extracellular space (BMP7) growth (BMP7)
extracellular region (BMP7)
Anatomy Link Frequency
cartilage 5
brain 2
fibroblasts 2
annulus 2
dentin 2
BMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 113 99.56 Very High Very High Very High
fibrosis 4 99.20 Very High Very High Very High
cytokine 242 99.04 Very High Very High Very High
chemokine 60 98.72 Very High Very High Very High
imagery 58 98.60 Very High Very High Very High
Osteoarthritis 154 98.44 Very High Very High Very High
rheumatoid arthritis 21 97.92 Very High Very High Very High
substance P 6 96.36 Very High Very High Very High
pulpitis 4 94.76 High High
ischemia 50 90.44 High High
Disease Link Frequency Relevance Heat
Squamous Cell Carcinoma 244 99.96 Very High Very High Very High
Adenocarcinoma 248 99.80 Very High Very High Very High
INFLAMMATION 115 99.56 Very High Very High Very High
Stroke 45 99.28 Very High Very High Very High
Fibrosis 4 99.20 Very High Very High Very High
Middle Cerebral Artery Infarction 245 99.08 Very High Very High Very High
Focal Cartilage Defect 32 99.04 Very High Very High Very High
Intervertebral Disk Degeneration 142 98.88 Very High Very High Very High
Osteoarthritis 185 98.68 Very High Very High Very High
Aging 37 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Gene_expression (expression) of BMP-7
1) Confidence 0.71 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
Based on these findings, the authors suggested that LMP-1 upregulates the gene expression of BMP-2 and BMP-7 and that the increased level of BMP production resulted in an increased PG synthesis.
Gene_expression (expression) of BMP-7
2) Confidence 0.71 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.12 Pain Relevance 0.03
The OP-1 injection to the degenerative disc stimulated an anabolic response characterized by the restoration of the normal morphology of the disc, increased Safranin O staining in the NP, extention of the extracellular matrix, and stimulation of endogenous OP-1 synthesis in the NP, annulus fibrosis (AF), and end-plate.
Gene_expression (synthesis) of OP-1 in annulus associated with fibrosis
3) Confidence 0.71 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17205567 Disease Relevance 0.59 Pain Relevance 0.35
BMP-7 expression did not correlate with cartilage defect size; average expression in both intervention groups did not statistically significant differ (0.01 ± 0.22 pg/ml vs. 8.56 ± 24.22 pg/ml, p = 0.44, power 57.94%).
Gene_expression (expression) of BMP-7 in cartilage associated with focal cartilage defect
4) Confidence 0.65 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.16 Pain Relevance 0.03
The OP-1 injection to the degenerative disc stimulated an anabolic response characterized by the restoration of the normal morphology of the disc, increased Safranin O staining in the NP, extention of the extracellular matrix, and stimulation of endogenous OP-1 synthesis in the NP, annulus fibrosis (AF), and end-plate.
Gene_expression (injection) of OP-1 in annulus associated with fibrosis
5) Confidence 0.62 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17205567 Disease Relevance 0.42 Pain Relevance 0.13
BMP-2 and BMP-7 belong to the transforming growth factor-beta (TGF-?)
Gene_expression (belong) of BMP-7
6) Confidence 0.56 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.11 Pain Relevance 0.10
In order to measure concentrations of the indicated proteins, commercially available ELISA kits provided by R&D Systems (Wiesbaden-Nordenstadt, Germany) for BMP-2, BMP-7, bFGF, IGF-I, IL-1?
Gene_expression (provided) of BMP-7
7) Confidence 0.56 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.16 Pain Relevance 0
BMP-7 was synthesised by human articular chondrocytes [36,38] of different age and various degrees of degeneration including OA, but the level of gene and protein expression was dramatically reduced with cartilage aging and degenerative destruction [36,37].
Gene_expression (synthesised) of BMP-7 in cartilage associated with aging and osteoarthritis
8) Confidence 0.56 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.89 Pain Relevance 0.28
ELISAs for BMP-2, BMP-7, bFGF, IGF-1, IL-1?
Gene_expression (ELISAs) of BMP-7
9) Confidence 0.56 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.17 Pain Relevance 0
This is supported by the data of Honsawek et al., who described increased BMP-7 levels in knees of patients with progressive OA [19] The circumstance that in our trial only patients with circumscribed cartilage lesions were included (and patients with advanced OA were excluded) may make clear why synovial concentrations were mainly found below the detection level and, therefore, did not correlate with the clinical score.
Gene_expression (levels) of BMP-7 in knees associated with osteoarthritis
10) Confidence 0.56 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.65 Pain Relevance 0.23
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Gene_expression (expression) of BMP-7
11) Confidence 0.55 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
Six weeks after the OP-1 injection, a restoration of disc height and MRI changes were observed and sustained for the entire experimental period, up to 24 weeks (Fig. 2).62 In another degeneration model using C-ABC, 4 weeks following the injection of C-ABC, OP-1 (100¼g/disc) injection restored the disc height up to 12 weeks after the OP-1 injection.63 These data suggest that OP-1 may be utilized in patients with disc degeneration who had received chemonucleolysis in the past that resulted in some loss of disc height.


Gene_expression (injection) of OP-1 associated with intervertebral disk degeneration and imagery
12) Confidence 0.54 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.24 Pain Relevance 0.14
Therefore, data about intraarticular levels of BMP-2 and BMP-7 in knees with circumscribed cartilage lesions and their correlation with clinical scores are introduced.
Gene_expression (levels) of BMP-7 in cartilage
13) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.07 Pain Relevance 0.11
There was no statistically significant change in BMP-7 levels at day 1 post surgery (8.56 ± 24.22 pg/ml vs. 57.25 ± 137.89 pg/ml, n = 28, p = 0.09, power 46.56%), and no significant difference of BMP-7 levels comparing day 1 and day 2 (6.53 ± 7.23 pg/ml, n = 6, p = 0.26, power 5.98%) after the operation.


Gene_expression (levels) of BMP-7
14) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.15 Pain Relevance 0.07
BMP-7 was mainly localized in the cartilage layer [38], but was also detected in the synovial knee fluid of patients with OA and rheumatoid arthritis (RA) [18].
Gene_expression (detected) of BMP-7 in cartilage associated with rheumatoid arthritis and osteoarthritis
15) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.92 Pain Relevance 0.29
Expression of BMP7, TGFBR2, and FOS was collectively compared in all datasets except for the Database 5 that had only SCC available.
Gene_expression (Expression) of BMP7 associated with squamous cell carcinoma
16) Confidence 0.48 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.04 Pain Relevance 0
These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.
Gene_expression (expression) of BMP7 associated with squamous cell carcinoma and adenocarcinoma
17) Confidence 0.48 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.09 Pain Relevance 0
Levels of BMP-7 did not change after surgical cartilage repair, whereas concentrations of BMP-2 statistically significant increased after the intervention (p < 0.001).
Gene_expression (Levels) of BMP-7 in cartilage
18) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2920860 Disease Relevance 0 Pain Relevance 0
Two genes, BMP7 and JAG1, were also among the 23 genes that had 4-fold or greater expression in SCC than in AD reported in a separate paper [29].
Gene_expression (expression) of BMP7 associated with adenocarcinoma and squamous cell carcinoma
19) Confidence 0.42 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.56 Pain Relevance 0
Among the 11 datasets, majority of them show that BMP7 is up-regulated and TGFBR2/FOS are down-regulated in both AD and SCC compared to normal lung, whereas between AD and SCC, BMP7 has an opposite expression pattern to TGFBR2/FOS (Figure 5).
Gene_expression (expression) of BMP7 in lung associated with squamous cell carcinoma and adenocarcinoma
20) Confidence 0.42 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.09 Pain Relevance 0

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