INT141150

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.84
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (BMP7) extracellular space (BMP7) growth (BMP7)
extracellular region (BMP7)
Anatomy Link Frequency
cartilage 2
nucleus pulposus 1
BMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 26 96.16 Very High Very High Very High
rheumatoid arthritis 2 95.88 Very High Very High Very High
cytokine 42 93.84 High High
chemokine 12 90.20 High High
substance P 3 83.28 Quite High
Inflammation 13 60.04 Quite High
fibrosis 1 52.16 Quite High
ischemia 10 50.00 Quite Low
Pain 14 25.00 Low Low
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 62 99.92 Very High Very High Very High
Squamous Cell Carcinoma 61 99.28 Very High Very High Very High
Aging 2 98.44 Very High Very High Very High
Osteoarthritis 26 96.16 Very High Very High Very High
Rheumatoid Arthritis 4 95.88 Very High Very High Very High
Intervertebral Disk Degeneration 3 89.28 High High
Hypertrophy 2 87.24 High High
Middle Cerebral Artery Infarction 49 82.40 Quite High
Cancer 42 81.84 Quite High
Necrosis 3 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirty-four rats were divided into five groups: intact control; sham control; compressed nucleus pulposus (NP) injected with saline; and two OP-1 groups: COP-1 group (compression was continued after intradiscal OP-1 injection) and ROP-1 group (compression was released at the time of OP-1 injection).
Localization (released) of OP-1 in nucleus pulposus
1) Confidence 0.56 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17205567 Disease Relevance 0.38 Pain Relevance 0.07
BMP-7 was mainly localized in the cartilage layer [38], but was also detected in the synovial knee fluid of patients with OA and rheumatoid arthritis (RA) [18].
Localization (localized) of BMP-7 in cartilage associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.55 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.91 Pain Relevance 0.28
These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.
Localization (targeting) of BMP7 associated with squamous cell carcinoma and adenocarcinoma
3) Confidence 0.46 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.04 Pain Relevance 0
, fractalkine and MCP-1 was low and expression of VEGF, BMP-7, IL-1?
Localization (low) of BMP-7
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909196 Disease Relevance 0.28 Pain Relevance 0.25
After publication of the results gained for the regulators of cartilage metabolism bFGF and IGF-I [3], this article focuses on the role of the Bone morphogenetic proteins 2 and 7 (BMP-2, BMP-7) that both are recognized as candidate growth factors with good potential in cartilage tissue engineering as well as cartilage repair.
Localization (role) of BMP-7 in cartilage
5) Confidence 0.28 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.23 Pain Relevance 0.16

General Comments

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