INT141151

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 8.19
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD1) cytosol (PSMD1) nucleoplasm (PSMD1)
small molecule metabolic process (PSMD1) cellular nitrogen compound metabolic process (PSMD1)
Anatomy Link Frequency
muscle 2
cortex 2
facet 1
anterior 1
primary somatosensory cortex 1
PSMD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 64 100.00 Very High Very High Very High
Facet joint 18 100.00 Very High Very High Very High
insula 30 98.52 Very High Very High Very High
Hyperalgesia 6 98.38 Very High Very High Very High
Anterior cingulate cortex 29 98.20 Very High Very High Very High
Pain 500 98.04 Very High Very High Very High
imagery 226 98.04 Very High Very High Very High
backache 101 96.04 Very High Very High Very High
Lasting pain 184 92.76 High High
allodynia 19 90.80 High High
Disease Link Frequency Relevance Heat
Muscular Atrophy 150 100.00 Very High Very High Very High
Neurologic Manifestations 8 99.98 Very High Very High Very High
Disease 75 99.74 Very High Very High Very High
Cognitive Disorder 59 98.64 Very High Very High Very High
Hyperalgesia 6 98.38 Very High Very High Very High
Pain 686 98.04 Very High Very High Very High
Complex Regional Pain Syndromes 35 97.80 Very High Very High Very High
Colon Cancer 12 97.32 Very High Very High Very High
Low Back Pain 116 97.20 Very High Very High Very High
Toxicity 1 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They demonstrated greater reactivity in the primary somatosensory cortex (S1) and an expansion of the S1 representation of the back in CLBP patients.
Regulation (expansion) of S1 in primary somatosensory cortex associated with primary somatosensory cortex
1) Confidence 0.40 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2266926 Disease Relevance 0.09 Pain Relevance 0.36
We have demonstrated that there is directed coherence in the S1/area 5???
Regulation (directed) of S1 associated with primary somatosensory cortex
2) Confidence 0.32 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2927302 Disease Relevance 0 Pain Relevance 0.14
Thus, modulation of S1 activity contingent upon observation of others' pain and touch may reflect the mapping of sensory qualities of observed painful and tactile stimuli.
Regulation (modulation) of S1 associated with pain and primary somatosensory cortex
3) Confidence 0.27 Published 2007 Journal Cereb. Cortex Section Abstract Doc Link 17205974 Disease Relevance 0.50 Pain Relevance 0.90
mRNA is significantly down-regulated during both the early and late phases of immobilization-induced muscle atrophy (Table S1, Figure S5).
Regulation (regulated) of S1 in muscle associated with muscular atrophy
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.16 Pain Relevance 0
The genes corresponding to these probes were organized into functional categories, and the number of up-regulated and down-regulated genes within each functional category was then compared to determine whether categories were generally up- or down-regulated during muscle atrophy (Figure 1 and S1).
Spec (whether) Regulation (regulated) of S1 in muscle associated with muscular atrophy
5) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.26 Pain Relevance 0
Other functional groups were also significantly up-regulated or down-regulated in specific analyses but only the bioenergetics gene category was significantly down-regulated in all micro-array analyses (Figures 1 and S1).
Spec (analyses) Regulation (regulated) of S1
6) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.14 Pain Relevance 0
Von-Frey stimulation of the affected limb in adult patients with CRPS evoked pinprick hyperalgesia and produced greater contralateral activation than identical stimulation of the unaffected limb in primary (S1) and secondary (S2) sensory cortex, insula, anterior cingulate cortex, and frontal cortices [104,105].
Neg (unaffected) Regulation (unaffected) of S1 in insula associated with complex regional pain syndromes, hyperalgesia, insula and anterior cingulate cortex
7) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 1.34 Pain Relevance 1.11
In the past cases, the L5-S1 facet joint was mostly affected (80%).
Regulation (affected) of S1 in facet associated with facet joint
8) Confidence 0.17 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2948130 Disease Relevance 0.27 Pain Relevance 0.38
Eighty-six (38%) subjects had Modic change at L5-S1; 25 (11%) had type I, 58 (25%) type II, and three subjects had both type I and type II change at L5-S1.
Regulation (change) of L5-S1
9) Confidence 0.16 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2373785 Disease Relevance 0.33 Pain Relevance 0.04
Analyses were carried out for all lumbar levels combined and separately for changes located at L5-S1.
Regulation (changes) of L5-S1
10) Confidence 0.16 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2373785 Disease Relevance 0.28 Pain Relevance 0
Modic changes are bone marrow lesions visible in magnetic resonance imaging (MRI), and they are assumed to be associated with symptomatic intervertebral disc disease, especially changes located at L5-S1.
Regulation (changes) of L5-S1 in intervertebral disc associated with disease and imagery
11) Confidence 0.10 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2373785 Disease Relevance 0.32 Pain Relevance 0.17
Stimulation of this specific site (but not other sites) in prefrontal cortex was then shown to suppress somatosensory evoked potentials and to facilitate working memory performance, consistent with the view that the connected prefrontal region was acting on S1 in a manner that suppressed processing of irrelevant sensory stimuli.
Regulation (acting) of S1 in cortex associated with cognitive disorder and primary somatosensory cortex
12) Confidence 0.09 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2950743 Disease Relevance 0.37 Pain Relevance 0.37
Occasional cases in which S-1/CPT-11 therapy was effective have been recently reported, and a high response rate in advanced colorectal cancer has also been reported1.
Regulation (effective) of S-1 associated with colon cancer
13) Confidence 0.07 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1395313 Disease Relevance 0.50 Pain Relevance 0
A subset S of X forms a complex when it enters state s1 if ?
Regulation (enters) of s1
14) Confidence 0.07 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Von-Frey stimulation of the affected limb in adult patients with CRPS evoked pinprick hyperalgesia and produced greater contralateral activation than identical stimulation of the unaffected limb in primary (S1) and secondary (S2) sensory cortex, insula, anterior cingulate cortex, and frontal cortices [104,105].
Neg (unaffected) Regulation (unaffected) of S1 in anterior associated with complex regional pain syndromes, hyperalgesia, insula and anterior cingulate cortex
15) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 1.34 Pain Relevance 1.11
Von-Frey stimulation of the affected limb in adult patients with CRPS evoked pinprick hyperalgesia and produced greater contralateral activation than identical stimulation of the unaffected limb in primary (S1) and secondary (S2) sensory cortex, insula, anterior cingulate cortex, and frontal cortices [104,105].
Neg (unaffected) Regulation (unaffected) of S1 in cortex associated with complex regional pain syndromes, hyperalgesia, insula and anterior cingulate cortex
16) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 1.34 Pain Relevance 1.11
The global analysis of the aCGH data on the three array platforms yielded a total of 111 loci whose copy number state frequencies differed among populations (Table S1), including 59 gains, 43 losses, and 9 complex changes which showed a range of variation that we could not assign to a single population (see Methods).
Regulation (differed) of S1
17) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747275 Disease Relevance 0 Pain Relevance 0
Radicular symptoms and neurologic deficit affecting the L5 or S1 nerve roots may be present with nerve root irritation and high grade spondylolisthesis.
Regulation (affecting) of S1 in nerve associated with low back pain and neurologic manifestations
18) Confidence 0.04 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3001419 Disease Relevance 0.94 Pain Relevance 0.18

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