INT141179

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.53
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1)
Apaf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 6 99.88 Very High Very High Very High
allodynia 1 99.38 Very High Very High Very High
Thermal hyperalgesia 1 98.88 Very High Very High Very High
Spinal cord 5 90.00 High High
Sciatic nerve 3 87.76 High High
Dorsal horn 2 84.96 Quite High
Neuropathic pain 4 79.56 Quite High
Pain 3 25.00 Low Low
imagery 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 6 99.88 Very High Very High Very High
Neuropathic Pain 5 99.38 Very High Very High Very High
Hyperalgesia 1 98.88 Very High Very High Very High
Apoptosis 7 97.28 Very High Very High Very High
Neurodegenerative Disease 7 59.12 Quite High
Disease 5 38.56 Quite Low
Microcephaly 6 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Chromosome Breakage 5 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of phenyl-N-tert-butylnitrone (PBN), a potent ROS scavenger, reduced the development of thermal hyperalgesia and mechanical allodynia at 1 and 3 days post-CCI, and decreased the mRNA levels of bax, apaf-1, and caspase-9.
Negative_regulation (decreased) of apaf-1 associated with allodynia, eae and thermal hyperalgesia
1) Confidence 0.41 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.42 Pain Relevance 1.14
More specifically, there was no significant reduction in the expression levels of Chk1, Brca1, Topbp1, Rad51, Ddb2, p73, Apaf1, or caspases which were all described to show reduced expression following MCPH1 knockdowns [34] (Tables S3, S4, S5).
Neg (no) Negative_regulation (reduction) of Apaf1
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.

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