INT141180

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.77
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1)
Anatomy Link Frequency
dorsal horn spinal cord 2
Apaf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 18 99.50 Very High Very High Very High
Dorsal horn 6 99.04 Very High Very High Very High
allodynia 3 99.00 Very High Very High Very High
Neuropathic pain 12 98.60 Very High Very High Very High
Spinal cord 15 98.56 Very High Very High Very High
Thermal hyperalgesia 3 98.50 Very High Very High Very High
Sciatic nerve 9 96.32 Very High Very High Very High
Inflammation 12 50.00 Quite Low
Pain 9 25.00 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 101 100.00 Very High Very High Very High
Coronary Artery Disease 3 99.80 Very High Very High Very High
Injury 20 99.50 Very High Very High Very High
Neuropathic Pain 15 99.00 Very High Very High Very High
Hyperalgesia 3 98.50 Very High Very High Very High
Frailty 17 93.76 High High
Cancer 119 82.12 Quite High
Neurodegenerative Disease 7 59.12 Quite High
Hyperplasia 1 53.12 Quite High
INFLAMMATION 13 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.
Gene_expression (expression) of apoptotic protease-activating factor-1 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord
1) Confidence 0.74 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.16 Pain Relevance 0.92
RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.
Gene_expression (expression) of apaf-1 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord
2) Confidence 0.74 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.17 Pain Relevance 0.93
of the proapoptotic genes Fas, FasL, p75NGFR, p53, Bax, caspase-3, and CAD, whereas expression of Apaf-1 and the anti-apoptotic gene Bcl-2 was unchanged (Figure 3D).


Gene_expression (expression) of Apaf-1 associated with coronary artery disease and apoptosis
3) Confidence 0.60 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 1.15 Pain Relevance 0
As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).
Gene_expression (mutation) of APAF-1 associated with apoptosis
4) Confidence 0.36 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.76 Pain Relevance 0
More specifically, there was no significant reduction in the expression levels of Chk1, Brca1, Topbp1, Rad51, Ddb2, p73, Apaf1, or caspases which were all described to show reduced expression following MCPH1 knockdowns [34] (Tables S3, S4, S5).
Gene_expression (expression) of Apaf1
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.12 Pain Relevance 0
Administration of phenyl-N-tert-butylnitrone (PBN), a potent ROS scavenger, reduced the development of thermal hyperalgesia and mechanical allodynia at 1 and 3 days post-CCI, and decreased the mRNA levels of bax, apaf-1, and caspase-9.
Gene_expression (levels) of apaf-1 associated with allodynia, eae and thermal hyperalgesia
6) Confidence 0.25 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.41 Pain Relevance 1.14

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