INT141184

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.48
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp9) peptidase activity (Casp9) mitochondrion (Casp9)
nucleus (Casp9) cytoplasm (Casp9)
Anatomy Link Frequency
spinal cords 1
neurons 1
Casp9 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 6 99.88 Very High Very High Very High
allodynia 1 99.38 Very High Very High Very High
Thermal hyperalgesia 1 98.88 Very High Very High Very High
Spinal cord 7 91.20 High High
Sciatic nerve 3 87.76 High High
Dorsal horn 2 84.96 Quite High
Neuropathic pain 4 79.56 Quite High
Inflammation 23 50.00 Quite Low
dexamethasone 1 31.12 Quite Low
Pain 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 8 99.88 Very High Very High Very High
Apoptosis 233 99.70 Very High Very High Very High
Neuropathic Pain 5 99.38 Very High Very High Very High
Hyperalgesia 1 98.88 Very High Very High Very High
Death 67 91.80 High High
Lymphatic System Cancer 287 87.72 High High
Disease 54 75.44 Quite High
Cancer 54 74.32 Quite High
Disease Progression 12 65.44 Quite High
Thymoma 3 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of phenyl-N-tert-butylnitrone (PBN), a potent ROS scavenger, reduced the development of thermal hyperalgesia and mechanical allodynia at 1 and 3 days post-CCI, and decreased the mRNA levels of bax, apaf-1, and caspase-9.
Negative_regulation (decreased) of caspase-9 associated with allodynia, eae and thermal hyperalgesia
1) Confidence 0.42 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.42 Pain Relevance 1.15
Besides, a significant inhibition of apoptosis was recorded in the presence of a caspase-9 inhibitor.
Negative_regulation (inhibitor) of caspase-9 associated with apoptosis
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.03 Pain Relevance 0
Guegan et al (2001) illustrated that the protein content of caspase 9 begins to decrease in the spinal cords from symptomatic G93A mice (3 mo of age) compared to nontransgenic control mice and that caspase 9 continues to decrease further in end stage G93A mice (5 mo of age).
Negative_regulation (decrease) of caspase 9 in spinal cords
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.72 Pain Relevance 0
For caspase inhibition assays, Z-IETD-FMK caspase-8 inhibitor or Z-LEHD-FMK caspase-9 inhibitor (Calbiochem) was added one hour prior to addition of Sags.
Negative_regulation (inhibitor) of caspase-9
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.65 Pain Relevance 0
For caspase inhibition assays, Z-IETD-FMK caspase-8 inhibitor or Z-LEHD-FMK caspase-9 inhibitor (Calbiochem) was added one hour prior to addition of Sags.
Negative_regulation (inhibitor) of caspase-9
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.64 Pain Relevance 0
Western blot analysis confirmed the increase of active caspase-3 immunoreactivity and the concomitant decrease of total caspase-9 level in TSM1 (Figure 3C) and primary cultured neurons (Figure 3D and 3E) upon MPP+ treatment.
Negative_regulation (decrease) of caspase-9 in neurons
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.12 Pain Relevance 0
As opposed to other members of the IAP family, XIAP is the only member capable of direct inhibition of both the execution and initiation phases of the apoptotic cascade; it inhibits apoptotic activation by inhibiting caspase-9, and inhibits the execution phase by inhibiting the effector caspases, caspase-3 and caspase-7 [15].
Negative_regulation (inhibiting) of caspase-9 associated with apoptosis
7) Confidence 0.03 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.90 Pain Relevance 0

General Comments

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