INT141184
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Administration of phenyl-N-tert-butylnitrone (PBN), a potent ROS scavenger, reduced the development of thermal hyperalgesia and mechanical allodynia at 1 and 3 days post-CCI, and decreased the mRNA levels of bax, apaf-1, and caspase-9. | |||||||||||||||
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Besides, a significant inhibition of apoptosis was recorded in the presence of a caspase-9 inhibitor. | |||||||||||||||
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Guegan et al (2001) illustrated that the protein content of caspase 9 begins to decrease in the spinal cords from symptomatic G93A mice (3 mo of age) compared to nontransgenic control mice and that caspase 9 continues to decrease further in end stage G93A mice (5 mo of age). | |||||||||||||||
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For caspase inhibition assays, Z-IETD-FMK caspase-8 inhibitor or Z-LEHD-FMK caspase-9 inhibitor (Calbiochem) was added one hour prior to addition of Sags. | |||||||||||||||
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For caspase inhibition assays, Z-IETD-FMK caspase-8 inhibitor or Z-LEHD-FMK caspase-9 inhibitor (Calbiochem) was added one hour prior to addition of Sags. | |||||||||||||||
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Western blot analysis confirmed the increase of active caspase-3 immunoreactivity and the concomitant decrease of total caspase-9 level in TSM1 (Figure 3C) and primary cultured neurons (Figure 3D and 3E) upon MPP+ treatment. | |||||||||||||||
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As opposed to other members of the IAP family, XIAP is the only member capable of direct inhibition of both the execution and initiation phases of the apoptotic cascade; it inhibits apoptotic activation by inhibiting caspase-9, and inhibits the execution phase by inhibiting the effector caspases, caspase-3 and caspase-7 [15]. | |||||||||||||||
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