INT141185

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 30
Total Number 34
Disease Relevance 20.73
Pain Relevance 8.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
liver 2
brain 2
nervous system 1
blood 1
neuronal 1
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 201 99.80 Very High Very High Very High
agonist 169 99.62 Very High Very High Very High
Spinal cord 11 99.56 Very High Very High Very High
diclofenac 66 99.52 Very High Very High Very High
Sciatic nerve 6 99.50 Very High Very High Very High
cytokine 104 99.32 Very High Very High Very High
acular 81 99.22 Very High Very High Very High
Eae 6 99.06 Very High Very High Very High
Pain 25 98.68 Very High Very High Very High
Arthritis 59 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Injury 106 99.96 Very High Very High Very High
INFLAMMATION 240 99.92 Very High Very High Very High
Injury 334 99.84 Very High Very High Very High
Stress 211 99.54 Very High Very High Very High
Diabetes Mellitus 101 99.46 Very High Very High Very High
Hypersensitivity 16 99.40 Very High Very High Very High
Disease 55 99.28 Very High Very High Very High
Apoptosis 64 99.20 Very High Very High Very High
Arthritis 64 98.60 Very High Very High Very High
Cv Unclassified Under Development 125 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, there has been considerable interest in the role of reactive oxygen species (ROS) in inflammatory disease, but little is known of the role of hydrogen peroxide (H(2)O(2)) in hyperalgesia.
Regulation (role) of ROS associated with hyperalgesia, inflammation and disease
1) Confidence 0.24 Published 2009 Journal Pain Section Abstract Doc Link 19059721 Disease Relevance 1.08 Pain Relevance 0.61
In conclusion, it was shown that ketorolac and diclofenac have an anti-oxidizing effect on ROS or an ROS-removing effect.
Regulation (effect) of ROS-removing associated with acular and diclofenac
2) Confidence 0.21 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.15 Pain Relevance 0.67
In conclusion, it was shown that ketorolac and diclofenac have an anti-oxidizing effect on ROS or an ROS-removing effect.
Regulation (effect) of ROS associated with acular and diclofenac
3) Confidence 0.21 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.14 Pain Relevance 0.67
Effects of ROS on aberrant signaling pathways in the nervous system remain to be determined.
Regulation (Effects) of ROS in nervous system
4) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.27 Pain Relevance 0.76
Thus the gold nanoparticles reinstate the organ damages in the diabetic system by their sustained control over the ROS generation and inhibition of lipid peroxidation.
Regulation (control) of ROS associated with diabetes mellitus
5) Confidence 0.17 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.88 Pain Relevance 0.06
To investigate the effect of SOD1 expression on ROS level in the liver, we stained each liver with the oxidation-dependent fluorescent dye DHE.
Spec (investigate) Regulation (effect) of ROS in liver
6) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.08 Pain Relevance 0
Changes of the aortic tone by ACh injection before ROS exposure (control) and after ROS exposure (experimental) were compared.


Regulation (control) of ROS
7) Confidence 0.12 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.06 Pain Relevance 0
Significant increases in ROS production do not occur in the present study until 30 minutes since ROS levels in cells are tightly regulated.
Regulation (regulated) of ROS
8) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.33 Pain Relevance 0.55
Alternatively, vitamin C may influence antibody production as a direct effect on B cells by modulating the level of intracellular reactive oxygen species (ROS) in these cells.
Regulation (modulating) of ROS in B cells
9) Confidence 0.12 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.17 Pain Relevance 0.04
To study the role of reactive oxygen species (ROS) in the brain on arterial blood flow, heart rate, and whole-body glucose utilization, hydrogen peroxide (H2O2) was infused into the lateral ventricle of the mice 120 min after the beginning of the hyperglycemic clamp.
Regulation (role) of ROS in brain
10) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0 Pain Relevance 0.08
Whether cholinergic agonist treatment has any effect on ROS generation is of interest.
Spec (Whether) Regulation (effect) of ROS associated with agonist
11) Confidence 0.09 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.70 Pain Relevance 0.32
A mouse model of neuropathic pain consisting of chronic constriction injury (CCI) of the sciatic nerve was used to examine the involvement of reactive oxygen species (ROS) in early spinal cord pro-apoptotic gene over-expression during the development of neuropathic pain.
Spec (examine) Regulation (involvement) of ROS in sciatic nerve associated with eae, injury, neuropathic pain, sciatic nerve, apoptosis and spinal cord
12) Confidence 0.09 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.04 Pain Relevance 0.84
Consequently, one of the most obvious ways to manage TBI may be to control ROS generation [1] given that animal experiments have supported the notion that free radical scavengers and antioxidants dramatically reduce cerebral damage [1,5,6].
Regulation (control) of ROS associated with brain injury
13) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 0.78 Pain Relevance 0
In summary, previous studies have proposed that the interaction of NO with cytochrome c oxidase is a regulated and physiologically relevant pathway that functions to control ROS formation for redox signalling and maintain O2 gradients in tissues [19].
Regulation (control) of ROS
14) Confidence 0.08 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.38 Pain Relevance 0
The generation of reactive oxygen species (ROS), including superoxide, hydrogen peroxide, and peroxynitrite, plays a central role in mechanotransduction (10).
Regulation (generation) of ROS associated with mechanotransduction
15) Confidence 0.08 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.46 Pain Relevance 0.13
Finally, intrathecal injection of phenyl-N-tert-butylnitrone (PBN), a reactive oxygen species (ROS) scavenger, ameliorated thermal and mechanical hypersensitivity, thus further confirming the importance of ROS including NO and superoxide in the maintenance of neuropathic pain.
Regulation (importance) of ROS associated with hypersensitivity, neuropathic pain and intrathecal
16) Confidence 0.07 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19111753 Disease Relevance 0.72 Pain Relevance 0.63
Specifically, this first study aimed to investigate the effects of reactive oxygen species (ROS) scavengers, antiinflammatory agents, and a calcium-channel blocker on pneumoperitoneum-enhanced adhesions.
Spec (investigate) Regulation (effects) of ROS associated with inflammation, adhesions and pneumoperitoneum
17) Confidence 0.06 Published 2007 Journal Surg Endosc Section Abstract Doc Link 17479336 Disease Relevance 1.04 Pain Relevance 0.08
Notably, the action of GLP-1R signaling for control of nitric oxide and ROS was strictly glucose dependent.
Regulation (control) of ROS
18) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.26 Pain Relevance 0.31
To determine whether changes in ROS could link GLP-1 receptor activation to the control of femoral arterial blood flow and whole-body glucose utilization rates, we performed a continuous infusion of oxygen peroxide into the lateral ventricular cavity of control mice under basal conditions.
Regulation (changes) of ROS in lateral
19) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.21 Pain Relevance 0.23
However, we cannot directly demonstrate that the ROS concentration and GST activity changes were located exclusively in GLP-1 receptor–expressing cells.
Regulation (changes) of ROS
20) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.31 Pain Relevance 0.11

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