INT141187

Context Info Confidence 0.49 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 4.20 Pain Relevance 1.00

cytosol (Casp9) peptidase activity (Casp9) mitochondrion (Casp9) nucleus (Casp9) cytoplasm (Casp9)

Anatomy Link Frequency dorsal horn spinal cord 2 Casp9 (Mus musculus)

Pain Link Frequency Relevance Heat Dorsal horn 2 99.68 Spinal cord 5 99.20 Neuropathic pain 4 99.00 Eae 6 98.20 Sciatic nerve 3 96.96 ischemia 3 77.68 Thermal hyperalgesia 1 74.48 allodynia 1 71.60 chemokine 21 50.00 alcohol 14 50.00

Disease Link Frequency Relevance Heat Apoptosis 94 100.00 Neuropathic Pain 5 99.00 Injury 8 97.36 Death 26 97.12 Carcinoma 25 96.24 Reperfusion Injury 2 78.44 Hypertrophic Cardiomyopathy 1 77.16 Cleidocranial Dysplasia 1 76.00 Myocardial Infarction 3 75.08 Colon Cancer 25 75.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.

Positive_regulation (increased) of Gene_expression (expression) of caspase-9 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord

1) Confidence 0.49 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.18 Pain Relevance 0.93

Our observation of significantly increased cytosolic expression of cytochrome C and pro-caspase-9 in ethanol-treated mice depicts an essential role of the mitochondrial death pathway in ethanol-induced apoptosis.

Positive_regulation (increased) of Gene_expression (expression) of pro-caspase-9 associated with apoptosis and death

2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.61 Pain Relevance 0.07

Immunoblot analysis indicated increased active, cleaved caspase-9 levels solely in non-adherent CXCL12-expressing cells compared to active caspase-8, suggesting an intrinsic apoptotic mechanism driving anoikis of those cells (Figure 4A).

Positive_regulation (increased) of Gene_expression (levels) of caspase-9 associated with apoptosis

3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.41 Pain Relevance 0

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