INT141187

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.20
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp9) peptidase activity (Casp9) mitochondrion (Casp9)
nucleus (Casp9) cytoplasm (Casp9)
Anatomy Link Frequency
dorsal horn spinal cord 2
Casp9 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 2 99.68 Very High Very High Very High
Spinal cord 5 99.20 Very High Very High Very High
Neuropathic pain 4 99.00 Very High Very High Very High
Eae 6 98.20 Very High Very High Very High
Sciatic nerve 3 96.96 Very High Very High Very High
ischemia 3 77.68 Quite High
Thermal hyperalgesia 1 74.48 Quite High
allodynia 1 71.60 Quite High
chemokine 21 50.00 Quite Low
alcohol 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 94 100.00 Very High Very High Very High
Neuropathic Pain 5 99.00 Very High Very High Very High
Injury 8 97.36 Very High Very High Very High
Death 26 97.12 Very High Very High Very High
Carcinoma 25 96.24 Very High Very High Very High
Reperfusion Injury 2 78.44 Quite High
Hypertrophic Cardiomyopathy 1 77.16 Quite High
Cleidocranial Dysplasia 1 76.00 Quite High
Myocardial Infarction 3 75.08 Quite High
Colon Cancer 25 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.
Positive_regulation (increased) of Gene_expression (expression) of caspase-9 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord
1) Confidence 0.49 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.18 Pain Relevance 0.93
Our observation of significantly increased cytosolic expression of cytochrome C and pro-caspase-9 in ethanol-treated mice depicts an essential role of the mitochondrial death pathway in ethanol-induced apoptosis.
Positive_regulation (increased) of Gene_expression (expression) of pro-caspase-9 associated with apoptosis and death
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.61 Pain Relevance 0.07
Immunoblot analysis indicated increased active, cleaved caspase-9 levels solely in non-adherent CXCL12-expressing cells compared to active caspase-8, suggesting an intrinsic apoptotic mechanism driving anoikis of those cells (Figure 4A).
Positive_regulation (increased) of Gene_expression (levels) of caspase-9 associated with apoptosis
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox