INT141191

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.33
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1)
Anatomy Link Frequency
dorsal horn spinal cord 4
Apaf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 4 99.04 Very High Very High Very High
Neuropathic pain 8 99.00 Very High Very High Very High
Spinal cord 10 98.56 Very High Very High Very High
Eae 12 97.56 Very High Very High Very High
Sciatic nerve 6 96.32 Very High Very High Very High
Thermal hyperalgesia 2 73.20 Quite High
allodynia 2 70.32 Quite High
Pain 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 14 100.00 Very High Very High Very High
Neuropathic Pain 10 99.00 Very High Very High Very High
Injury 12 96.72 Very High Very High Very High
Hyperalgesia 2 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.
Positive_regulation (increased) of Gene_expression (expression) of apaf-1 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord
1) Confidence 0.48 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.17 Pain Relevance 0.93
RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.
Positive_regulation (increased) of Gene_expression (expression) of apoptotic protease-activating factor-1 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord
2) Confidence 0.48 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.17 Pain Relevance 0.92

General Comments

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