INT141233

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
nucleus accumbens 2
sympathetic 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 84 100.00 Very High Very High Very High
Nucleus accumbens 46 99.68 Very High Very High Very High
agonist 4 99.46 Very High Very High Very High
cocaine 15 93.16 High High
gABA 20 92.20 High High
antagonist 8 90.80 High High
Ventral tegmentum 24 80.76 Quite High
GABAergic 11 76.92 Quite High
withdrawal 34 74.64 Quite High
Opioid 8 63.72 Quite High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 1 91.92 High High
Autonomic Nervous System Disease 1 87.60 High High
Orthostatic Intolerance /

Orthostatic Intolerance

1 76.00 Quite High
Pressure Volume 2 Under Development 2 73.08 Quite High
Drug Dependence 24 61.64 Quite High
Recurrence 3 41.40 Quite Low
Anxiety Disorder 2 20.16 Low Low
Opiate Addiction 10 5.00 Very Low Very Low Very Low
Vomiting 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-DOPS is very effective in treatment of deficiency of dopamine-beta-hydroxylase (DBH), the enzyme required for conversion of dopamine to NE in sympathetic nerves.
Negative_regulation (deficiency) of Positive_regulation (required) of DBH in sympathetic associated with dopamine
1) Confidence 0.42 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 17214596 Disease Relevance 0.25 Pain Relevance 0.12
A similar conclusion was obtained in another study in which GABAB receptor agonist baclofen dose dependently reduced heroin-induced dopamine release in the nucleus accumbens and inhibited heroin self-administration behavior (37).
Negative_regulation (reduced) of Positive_regulation (induced) of dopamine release in nucleus accumbens associated with nucleus accumbens, dopamine and agonist
2) Confidence 0.01 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529396 Disease Relevance 0.06 Pain Relevance 1.21

General Comments

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