INT14124

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 34
Total Number 34
Disease Relevance 7.48
Pain Relevance 10.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adra1a) plasma membrane (Adra1a) cellular_component (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
smooth muscle 1
liver 1
tail 1
vessels 1
external 1
Adra1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 51 100.00 Very High Very High Very High
Potency 8 100.00 Very High Very High Very High
Catecholamine 4 100.00 Very High Very High Very High
noradrenaline 21 99.84 Very High Very High Very High
agonist 36 99.74 Very High Very High Very High
cva 5 99.38 Very High Very High Very High
opiate 13 99.36 Very High Very High Very High
Serotonin 7 99.12 Very High Very High Very High
Pain 3 98.92 Very High Very High Very High
Clonidine 34 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 20 99.86 Very High Very High Very High
Fever 1 99.68 Very High Very High Very High
Thyroid Disease 3 99.60 Very High Very High Very High
Cv General 3 Under Development 5 99.38 Very High Very High Very High
Ganglion Cysts 2 99.28 Very High Very High Very High
Chronic Pelvic Pain Syndrome 2 99.24 Very High Very High Very High
Serotonin Syndrome 1 99.12 Very High Very High Very High
Heart Rate Under Development 10 99.00 Very High Very High Very High
Convulsion 9 98.94 Very High Very High Very High
Decapitation 5 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, such an opiate mechanism triggered by central alpha 1-adrenoceptor blockade seems to be either absent or inactive in SH rats.
Negative_regulation (blockade) of alpha 1-adrenoceptor associated with hypertension and opiate
1) Confidence 0.59 Published 1986 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 2878946 Disease Relevance 0.48 Pain Relevance 0.53
The alpha 1-adrenoreceptor is stimulated preferentially by methoxamine and cirazoline and blocked selectively by prazosin or corynanthine.
Negative_regulation (blocked) of alpha 1-adrenoreceptor
2) Confidence 0.58 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6210422 Disease Relevance 0.07 Pain Relevance 0.36
These data indicated that specific blockade of central alpha 1-adrenergic receptors prevents apomorphine-enhanced startle.
Negative_regulation (blockade) of alpha 1-adrenergic
3) Confidence 0.43 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2859209 Disease Relevance 0.06 Pain Relevance 0.41
However, a combination of alpha-adrenoceptor blockade and Ca antagonist inhibited this pressor response.
Negative_regulation (blockade) of alpha-adrenoceptor associated with antagonist
4) Confidence 0.43 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3820061 Disease Relevance 0.10 Pain Relevance 0.18
However, central alpha 1-adrenoceptors are probably not the common sites of interaction, since any alpha 1-adrenoceptor-stimulating potency is lacking for R 28935 (R 29814) and their (moderate) affinity for alpha 1-adrenoceptors bears no relationship to their hypotensive activity.
Negative_regulation (lacking) of alpha 1-adrenoceptor-stimulating associated with hypotension and potency
5) Confidence 0.43 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7073408 Disease Relevance 0.41 Pain Relevance 0.16
Prazosin which showed postsynaptic alpha 1 adrenoceptor blocking activity reduced avoidance behaviour.
Negative_regulation (blocking) of alpha 1 adrenoceptor
6) Confidence 0.43 Published 1983 Journal Acta Physiol Pol Section Abstract Doc Link 6145294 Disease Relevance 0 Pain Relevance 0.40
In addition, 2-aminomethyl-1,4-benzodioxan itself both exhibited reasonable presynaptic alpha-adrenoceptor blocking activity, whilst being devoid of activity postsynaptically.
Negative_regulation (blocking) of alpha-adrenoceptor
7) Confidence 0.43 Published 1981 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6121847 Disease Relevance 0 Pain Relevance 0.39
Accordingly, one and the same molecule possesses the following pharmacodynamic properties: postsynaptic alpha 1-adrenoceptor blockade; weak postsynaptic alpha 2-adrenoceptor blockade; modest but selective beta 1-adrenoceptor blockade with ISA; central hypotensive activity not mediated by central alpha 2-adrenoceptors.
Negative_regulation (blockade) of alpha 1-adrenoceptor associated with hypotension
8) Confidence 0.43 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 4051641 Disease Relevance 0.27 Pain Relevance 0.20
Alpha adrenoceptor blockade did not alter the salbutamol-evoked facilitation at 0.1 Hz but revealed salbutamol-evoked facilitation at 0.5 Hz.
Negative_regulation (blockade) of Alpha adrenoceptor
9) Confidence 0.42 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853165 Disease Relevance 0.08 Pain Relevance 0.20
We suggest that the alpha-adrenoceptor blocking activity of vesamicol is a function of the phenylpiperidino moiety of the molecule.
Negative_regulation (blocking) of alpha-adrenoceptor
10) Confidence 0.42 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1686588 Disease Relevance 0 Pain Relevance 0.36
[Treatment of external RF hyperthermia combining with alpha 1-adrenergic receptor blocker for patients with prostatodynia and chronic non-bacterial prostatitis].
Negative_regulation (blocker) of alpha 1-adrenergic in external associated with pain, prostatitis, fever and chronic pelvic pain syndrome
11) Confidence 0.41 Published 2002 Journal Zhonghua Nan Ke Xue Section Title Doc Link 12479049 Disease Relevance 0.30 Pain Relevance 0.29
Alpha-adrenergic blockade in vasotonic angina: lack of efficacy of specific alpha 1-receptor blockade with prazosin.
Negative_regulation (blockade) of alpha 1-receptor associated with cva
12) Confidence 0.40 Published 1983 Journal J. Am. Coll. Cardiol. Section Title Doc Link 6138377 Disease Relevance 0.53 Pain Relevance 0.42
Inhibition of post-decapitation convulsions in the rat by dibenzothiepin neuroleptics via alpha 1-adrenoceptor blockade.
Negative_regulation (blockade) of 1-adrenoceptor associated with convulsion and decapitation
13) Confidence 0.38 Published 1988 Journal Eur. J. Pharmacol. Section Title Doc Link 2897923 Disease Relevance 1.08 Pain Relevance 0.31
In contrast, only alpha 1-adrenoceptor-mediated pressor responses are reduced by sympathectomy, suggesting that neurally released NA acts mainly on alpha 1-adrenoceptors.
Negative_regulation (reduced) of alpha 1-adrenoceptor-mediated associated with noradrenaline
14) Confidence 0.37 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2419696 Disease Relevance 0.13 Pain Relevance 0.25
In contrast, disruption of noradrenergic functioning via either alpha-1 receptor blockade or alpha-2 receptor stimulation disrupts both the HR and behavioral components of the OR.
Negative_regulation (blockade) of alpha-1 receptor
15) Confidence 0.36 Published 1990 Journal Behav. Neural Biol. Section Abstract Doc Link 1964043 Disease Relevance 0 Pain Relevance 0.34
However, T3-induced hyperthyroidism caused a selective reduction in postjunctional alpha 2-adrenoceptor-mediated pressor responses but not alpha 1-adrenoceptor-mediated ones in both age groups.
Negative_regulation (reduction) of 1-adrenoceptor-mediated associated with thyroid disease
16) Confidence 0.35 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2824894 Disease Relevance 0.33 Pain Relevance 0.24
In Experiment 2, the opiate receptor blocker naltrexone also failed to inhibit the HR and behavioral expressions of the OR. alpha-1 adrenergic receptor blockade with WB-4101 in Experiment 3 abolished both the HR and behavioral ORs to the pulsating tone.
Negative_regulation (abolished) of alpha-1 adrenergic receptor associated with opiate
17) Confidence 0.32 Published 1990 Journal Behav. Neural Biol. Section Abstract Doc Link 1964043 Disease Relevance 0 Pain Relevance 0.38
In Experiment 2, the opiate receptor blocker naltrexone also failed to inhibit the HR and behavioral expressions of the OR. alpha-1 adrenergic receptor blockade with WB-4101 in Experiment 3 abolished both the HR and behavioral ORs to the pulsating tone.
Negative_regulation (inhibit) of alpha-1 adrenergic receptor associated with opiate
18) Confidence 0.32 Published 1990 Journal Behav. Neural Biol. Section Abstract Doc Link 1964043 Disease Relevance 0 Pain Relevance 0.37
These results indicate that moderate inhibition of cerebral alpha 1-adrenergic transmission facilitates paradoxical sleep in the cat.
Negative_regulation (inhibition) of alpha 1-adrenergic
19) Confidence 0.29 Published 1984 Journal Acta Physiol. Scand. Section Abstract Doc Link 6146242 Disease Relevance 0.09 Pain Relevance 0.24
Desensitization of alpha-1 adrenoceptor (alpha1AR)-mediated responses in aortic smooth muscle after exposure to catecholamines or alpha1AR agonists has been widely demonstrated.
Negative_regulation (Desensitization) of alpha-1 adrenoceptor in smooth muscle associated with catecholamine and agonist
20) Confidence 0.23 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.26

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