INT14125

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Context Info
Confidence 0.35
First Reported 1991
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.85
Pain Relevance 4.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 4
nucleus accumbens 2
shell 2
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 765 100.00 Very High Very High Very High
Nucleus accumbens 90 99.86 Very High Very High Very High
Delta opioid receptors 2 99.16 Very High Very High Very High
antagonist 46 98.36 Very High Very High Very High
Enkephalin 8 92.28 High High
Opioid 4 90.92 High High
opioid receptor 1 89.84 High High
midbrain 105 77.72 Quite High
Kappa opioid receptor 1 77.56 Quite High
agonist 42 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 25 91.52 High High
Attention Deficit Hyperactivity Disorder 815 69.12 Quite High
Urological Neuroanatomy 10 65.04 Quite High
Congenital Anomalies 10 63.88 Quite High
Depression 5 46.88 Quite Low
Ocular Toxicity (including Many Sub-types) 55 5.00 Very Low Very Low Very Low
Cognitive Disorder 45 5.00 Very Low Very Low Very Low
Hypertension 35 5.00 Very Low Very Low Very Low
Hypoxia 20 5.00 Very Low Very Low Very Low
Sprains And Strains 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A likely explanation could also be that elevated extracellular dopamine levels could have resulted from decreased DAT1 expression during the first postnatal month of SHR [50] which caused compensatory upregulation of both DAT1 and DRD2 receptors [51,58,77].
Positive_regulation (caused) of Positive_regulation (upregulation) of DRD2 associated with dopamine
1) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.15 Pain Relevance 0.61
Results are consistent with increased endogenous activation of DRD2 in the nucleus accumbens while increased efficacy of endogenous dopamine activation of DRD2 autoreceptors was suggested to account for the decreased stimulus-evoked release of dopamine in SHR striatum [77].
Positive_regulation (increased) of Positive_regulation (activation) of DRD2 in nucleus accumbens associated with nucleus accumbens and dopamine
2) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.12 Pain Relevance 0.80
The elevated dopamine concentration in the nucleus accumbens shell may have increased activation of endogenous DRD2 autoreceptors and thus reduced stimulus-evoked dopamine release [54].
Positive_regulation (increased) of Positive_regulation (activation) of DRD2 in shell associated with nucleus accumbens and dopamine
3) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.12 Pain Relevance 0.89
In vitro findings provided further support, where methylphenidate released significantly less dopamine from SHR nucleus accumbens slices than WKY [58], and chronic methylphenidate treatment (3 mg/kg for 2 weeks) increased endogenous dopamine activation of DRD2 in WKY striatum but did not alter DRD2 function in SHR probably because DRD2 were already up-regulated in SHR and no longer responsive to increases in extracellular dopamine [141].
Neg (not) Positive_regulation (increased) of Positive_regulation (activation) of DRD2 in striatum associated with nucleus accumbens and dopamine
4) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.38 Pain Relevance 0.42
Results are consistent with increased endogenous activation of DRD2 in the nucleus accumbens while increased efficacy of endogenous dopamine activation of DRD2 autoreceptors was suggested to account for the decreased stimulus-evoked release of dopamine in SHR striatum [77].
Positive_regulation (increased) of Positive_regulation (activation) of DRD2 in striatum associated with nucleus accumbens and dopamine
5) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.08 Pain Relevance 0.71
In addition, the potent D2 receptor antagonist spiperone antagonised the effect of the extract suggesting a dopaminergic action mediated by D2 receptor activation.
Positive_regulation (mediated) of Positive_regulation (activation) of D2 receptor associated with antagonist
6) Confidence 0.22 Published 2000 Journal Phytomedicine Section Abstract Doc Link 11081988 Disease Relevance 0 Pain Relevance 0.33
These results suggest that mu- but not delta-opioid receptors play an inhibitory role in the behaviors induced by the selective activation of dopamine D2 receptors.
Positive_regulation (induced) of Positive_regulation (activation) of dopamine D2 associated with dopamine and delta opioid receptors
7) Confidence 0.12 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1686589 Disease Relevance 0 Pain Relevance 1.03

General Comments

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