INT141253

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.54
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 4
neuronal 2
spinal cord 2
TMJ 2
nociceptors 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 101 100.00 Very High Very High Very High
amygdala 1 100.00 Very High Very High Very High
Thalamus 1 100.00 Very High Very High Very High
spinal dorsal horn 13 99.88 Very High Very High Very High
Snapping jaw 7 99.84 Very High Very High Very High
nociceptor 6 99.84 Very High Very High Very High
Inflammation 15 99.68 Very High Very High Very High
qutenza 4 99.64 Very High Very High Very High
Spinal cord 30 97.28 Very High Very High Very High
Thermal hyperalgesia 9 94.72 High High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 7 99.84 Very High Very High Very High
INFLAMMATION 19 99.68 Very High Very High Very High
Injury 2 98.00 Very High Very High Very High
Hyperalgesia 22 94.72 High High
Pain 21 93.20 High High
Fever 3 89.92 High High
Disease 3 89.36 High High
Neuropathic Pain 69 87.60 High High
Increased Venous Pressure Under Development 3 86.44 High High
Diabetes Mellitus 68 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, TRPV1 transcription in amygdala, prefrontal cortex, and thalamus was not affected by TMJ inflammation and estradiol.
Neg (not) Regulation (affected) of Transcription (transcription) of TRPV1 in TMJ associated with snapping jaw, inflammation, thalamus and amygdala
1) Confidence 0.62 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592193 Disease Relevance 1.55 Pain Relevance 1.73
As little is understood about what controls TRPV1 RNA transcription in nociceptors, we functionally characterized the upstream portion of the rat TRPV1 gene.
Regulation (controls) of Transcription (transcription) of TRPV1 RNA in nociceptors associated with nociceptor
2) Confidence 0.53 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17217411 Disease Relevance 0.45 Pain Relevance 0.97
The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway.
Regulation (regulate) of Transcription (expression) of TRPV1 in neuronal
3) Confidence 0.45 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20390747 Disease Relevance 0.24 Pain Relevance 0
Effect of microglia inhibitors on mRNA levels of B1R, TRPV1, IL-1?
Regulation (Effect) of Transcription (levels) of TRPV1 in microglia associated with b1 receptor
4) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.62 Pain Relevance 0.72
The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.
Regulation (normalized) of Transcription (expression) of TRPV1 in spinal cord
5) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link 20587056 Disease Relevance 0.16 Pain Relevance 0
Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro.
Regulation (regulates) of Transcription (expression) of TRPV1 in neurons associated with qutenza
6) Confidence 0.27 Published 2010 Journal J Asian Nat Prod Res Section Title Doc Link 20390747 Disease Relevance 0.26 Pain Relevance 0.10
Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro.
Regulation (regulates) of Transcription (level) of TRPV1 in neurons associated with qutenza
7) Confidence 0.27 Published 2010 Journal J Asian Nat Prod Res Section Title Doc Link 20390747 Disease Relevance 0.26 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox