INT14126

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.63
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Grina) cellular_component (Grina) biological_process (Grina)
Anatomy Link Frequency
neuronal 1
molecular layer 1
forebrain 1
Grina (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 350 100.00 Very High Very High Very High
antagonist 46 100.00 Very High Very High Very High
IPN 2 99.92 Very High Very High Very High
Pain 160 99.04 Very High Very High Very High
Neuropeptide 1 98.50 Very High Very High Very High
agonist 17 97.36 Very High Very High Very High
Cancer pain 17 96.76 Very High Very High Very High
cytokine 33 95.84 Very High Very High Very High
fortral 3 93.84 High High
Dextromethorphan 3 92.68 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.92 Very High Very High Very High
Targeted Disruption 126 99.20 Very High Very High Very High
Pain 170 99.04 Very High Very High Very High
Bone Cancer 41 98.80 Very High Very High Very High
Leishmaniasis 33 98.52 Very High Very High Very High
Convulsion 21 97.16 Very High Very High Very High
Cognitive Disorder 65 96.52 Very High Very High Very High
Repression 1 94.04 High High
Urological Neuroanatomy 141 93.44 High High
Decapitation 5 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, (+)-3-PPP-induced increases in levels of cGMP were reversed by the competitive N-methyl-D-aspartate (NMDA) antagonist, CPP]3-(2-carboxypiperazin-4-yl)propyl- 1-phosphonic acid, the non-competitive NMDA antagonist, (+)-MK-801 (dizocilipine maleate), the NMDA-associated glycine receptor antagonist, HA-966 (3-amino-1-hydroxypyrrolidin-2-one), the partial glycine agonist, DCS (D-cycloserine) as well as by the sigma ligands, ifenprodil, WY-47384, (+)-pentazocine, (+)-SKF 10,047, dextromethorphan and dextrorphan but not by rimcazole.
Gene_expression (antagonist) of NMDA-associated glycine receptor associated with fortral, antagonist, dextromethorphan and agonist
1) Confidence 0.67 Published 1991 Journal Brain Res. Section Abstract Doc Link 1686745 Disease Relevance 0 Pain Relevance 0.48
Prior to treatment there were high levels of LAg-specific IL-10 and TGF-?
Gene_expression (levels) of LAg
2) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.30 Pain Relevance 0.13
The mice that underwent reference testing prior to cued testing were used for the assessment of NMDA receptor subunit expression.
Gene_expression (expression) of NMDA receptor subunit associated with nmda receptor
3) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0.09 Pain Relevance 0.08
The most significant age-related declines in NMDA receptor subunit expression in these mice involved the ?
Gene_expression (expression) of NMDA receptor subunit associated with nmda receptor
4) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0.45 Pain Relevance 0.27
The present study was designed to determine whether there was a relationship between NMDA receptor subunit expression within crude synaptosomes and spatial reference memory ability in a two-day task.
Gene_expression (expression) of NMDA receptor subunit associated with nmda receptor
5) Confidence 0.13 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0.47 Pain Relevance 0.05
1 (NR2A) NMDA receptor subunit epsilon1 (2A)

?

Gene_expression (epsilon1) of NMDA receptor subunit associated with nmda receptor
6) Confidence 0.13 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0 Pain Relevance 0.13
1 (NR1) NMDA receptor subunit zeta1 (1)

Authors' contributions

Gene_expression (zeta1) of NMDA receptor subunit associated with nmda receptor
7) Confidence 0.13 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0 Pain Relevance 0.13
However, the NMDA receptor subunit NR2D is only present in the stratum oriens of the CA1 and CA2, the stratum lucidum of CA3 and the inner third of the molecular layer of the dentate gyrus [53].
Gene_expression (present) of NMDA receptor subunit in molecular layer associated with nmda receptor
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2763346 Disease Relevance 0.30 Pain Relevance 0.31
Moreover, we studied the expression of NMDA receptor scaffolding protein, PSD95 in neurabin KO mice.
Gene_expression (he express) of NMDA receptor scaffolding protein associated with targeted disruption and nmda receptor
9) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.83 Pain Relevance 0.40
Using Western blot, we found no difference in the expression of NMDA receptor protein subunits, NR1, NR2A or NR2B, in wild-type and TgDREAM mice (Figure 5A), suggesting that the genes encoding these subunits are not targets for DREAM repression.
Gene_expression (expression) of NMDA receptor protein associated with nmda receptor and repression
10) Confidence 0.11 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.18 Pain Relevance 0.56
In bone cancer models pain-related behaviors are accompanied by increased expression of NR2B, an NMDA receptor subunit.
Gene_expression (expression) of NMDA receptor subunit associated with pain, nmda receptor and bone cancer
11) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC3020802 Disease Relevance 0.61 Pain Relevance 0.60
Despite this clear difference in NMDA receptor subunit expression in the two neuronal populations, focally stimulated synaptic input is mediated exclusively by NR2A and 2B containing receptors in both neuronal populations.


Gene_expression (expression) of NMDA receptor subunit in neuronal associated with nmda receptor
12) Confidence 0.08 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2879240 Disease Relevance 0.24 Pain Relevance 0.58
Examples of transgenics that have generated
               insights into pain pathways are numerous, and include reports of modulation of pain
               behaviour by the overexpression of the neuropeptide galanin [28], and the enhancement of
               inflammatory pain by overexpression of the NMDA receptor subunit N2RB in the
               forebrain [29]. 
Gene_expression (overexpression) of NMDA receptor subunit in forebrain associated with pain, nmda receptor, ipn and neuropeptide
13) Confidence 0.03 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.16 Pain Relevance 0.85

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox