INT141272

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 8.27
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
blood 1
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 99.48 Very High Very High Very High
palliative 6 98.64 Very High Very High Very High
depression 3 95.24 Very High Very High Very High
Pain 10 94.44 High High
abdominal pain 6 94.36 High High
Endocannabinoid 117 91.28 High High
nud 2 82.88 Quite High
Cannabinoid 58 80.96 Quite High
agonist 2 58.08 Quite High
Versed 6 54.64 Quite High
Disease Link Frequency Relevance Heat
Prostate Cancer 306 99.84 Very High Very High Very High
Disease 156 99.84 Very High Very High Very High
Cancer 462 99.76 Very High Very High Very High
Gastrointestinal Disease 10 99.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

16 98.92 Very High Very High Very High
Metabolic Disorder 2 96.24 Very High Very High Very High
Depression 3 95.24 Very High Very High Very High
Anxiety Disorder 3 94.80 High High
Pain 10 94.44 High High
Abdominal Pain 6 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanolamides are considered to be potential pharmacodynamic biomarkers to determine target engagement for FAAH inhibition by novel pharmaceutical agents.
FAAH Binding (engagement) of
1) Confidence 0.48 Published 2010 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 20462810 Disease Relevance 0.38 Pain Relevance 0.14
The data presented here indicate that the degree to which FAAH is associated with disease severity and outcome are dependent upon the prevailing CB1IR.
FAAH Binding (associated) of associated with disease
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.39 Pain Relevance 0.03
There was no association of FAAH genotype with rectal sensation thresholds or ratings.
FAAH Neg (no) Binding (association) of
3) Confidence 0.37 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962356 Disease Relevance 0.77 Pain Relevance 0.38
There was a significant association of FAAH genotype with FGID phenotype (overall chi(2), P = 0.011) and with specific individual phenotypes (P = 0.048).
FAAH Binding (association) of associated with gastrointestinal disease
4) Confidence 0.37 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962356 Disease Relevance 0.91 Pain Relevance 0.47
Characterization of stability in purchased/aged blood indicated that ethanolamides are subject to degradation mediated by intracellular membrane-bound FAAH, which has been shown to be inhibited by phenylmethylsulfonyl fluoride (PMSF).
FAAH Binding (bound) of in blood
5) Confidence 0.37 Published 2010 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 20462810 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The presently developed Pyrosequencing assays allow for quick and reliable detection of FAAH genotypes and may facilitate investigations of FAAH genetic functional associations.


FAAH Binding (associations) of
6) Confidence 0.37 Published 2007 Journal Prostaglandins Other Lipid Mediat. Section Body Doc Link 17991615 Disease Relevance 0 Pain Relevance 0
For the 281 cases who only received palliative therapy at the end stages of the disease, a high tumour epithelial FAAH-IR was associated with a poor disease-specific survival.
FAAH Binding (associated) of associated with cancer, disease and palliative
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2924377 Disease Relevance 1.52 Pain Relevance 0.16
How do FAAH and CB1IR contribute to disease severity and outcome
FAAH Binding (contribute) of associated with disease
8) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.39 Pain Relevance 0
FAAH activity in prostate cancer cell lines is affected by interleukin-4
FAAH Binding (activity) of associated with prostate cancer
9) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 1.02 Pain Relevance 0.04
To our knowledge the only molecules known to regulate FAAH activity are the TH1 cytokines IL-12 and IFN?
FAAH Binding (activity) of associated with cytokine
10) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.62 Pain Relevance 0.13
Tumour epithelial FAAH-IR is associated with disease outcome
FAAH Binding (associated) of associated with cancer and disease
11) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.82 Pain Relevance 0.03
Since carboxylesterases hydrolyze a variety of ester-containing drugs and prodrugs, we speculate that certain FAAH inhibitors, by inhibiting carboxylesterases, might have drug-drug interactions with other medicines if developed as therapeutic agents.
FAAH Binding (interactions) of
12) Confidence 0.29 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17217969 Disease Relevance 0.21 Pain Relevance 0.08

General Comments

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