INT141275

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 15.83
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
T cell 8
brain 2
skin 2
lungs 2
heart 2
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 307 100.00 Very High Very High Very High
Inflammation 283 100.00 Very High Very High Very High
chemokine 76 100.00 Very High Very High Very High
psoriasis 5 98.56 Very High Very High Very High
Neuritis 8 97.92 Very High Very High Very High
Arthritis 75 95.64 Very High Very High Very High
rheumatoid arthritis 42 94.80 High High
Demyelination 3 93.92 High High
mu opioid receptor 4 93.12 High High
Inflammatory response 40 92.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 330 100.00 Very High Very High Very High
Burns 63 99.80 Very High Very High Very High
Atherosclerosis 69 99.20 Very High Very High Very High
Obesity 24 98.66 Very High Very High Very High
Experimental Autoimmune Neuritis 8 98.64 Very High Very High Very High
Psoriasis 5 98.56 Very High Very High Very High
Stress 28 98.32 Very High Very High Very High
Targeted Disruption 67 97.84 Very High Very High Very High
Mycobacterial Infection 145 96.60 Very High Very High Very High
Rhinitis 12 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This stress hormone has been reported to shift the immune response from Th1 to Th2 by the down-regulation of Th1 cytokine expression.
Negative_regulation (regulation) of Gene_expression (expression) of Th1 associated with stress and cytokine
1) Confidence 0.34 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20408448 Disease Relevance 1.43 Pain Relevance 0.71
IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis.
Negative_regulation (inhibits) of Gene_expression (production) of Th1 associated with experimental autoimmune neuritis, neuritis and cytokine
2) Confidence 0.31 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17218016 Disease Relevance 0.37 Pain Relevance 0.49
In contrast to most studies examining polyclonal T cell responses to ticks or tick derived molecules [4], the increase in IL-4 expression was not accompanied by reduced expression of the Th1 cytokine IFN-?
Negative_regulation (reduced) of Gene_expression (expression) of Th1 in T cell associated with cytokine
3) Confidence 0.28 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.34 Pain Relevance 0.18
This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.
Negative_regulation (inhibits) of Gene_expression (production) of Th1 associated with neuritis and cytokine
4) Confidence 0.27 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17218016 Disease Relevance 0.42 Pain Relevance 0.43
We found a clear reduction in Th1 response (IL-2 and IFN-?)
Spec (clear) Negative_regulation (reduction) of Gene_expression (response) of Th1
5) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.79 Pain Relevance 0.25
/IL-4 determining the Th1/Th2 ratio, was skewed to a Th1 response in both groups although much stronger in WT mice (figure 2C).


Negative_regulation (skewed) of Gene_expression (response) of Th1
6) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.21 Pain Relevance 0.07
, while Th1 response is defective.
Negative_regulation (defective) of Gene_expression (response) of Th1
7) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 1.16 Pain Relevance 0.24
To determine whether the cytokine response in the heart after burn was also related to changes in the Th1 and Th2 we analyzed heart tissue for IFN-?
Spec (whether) Negative_regulation (related) of Gene_expression (changes) of Th1 in heart associated with burns and cytokine
8) Confidence 0.24 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.82 Pain Relevance 0.21
Amongst host immune responses modulated by ixodid ticks, T cell cytokine polarization to an up-regulated Th2 profile appears to be a common strategy often accompanied by a decrease in Th1 cytokine expression [4].
Negative_regulation (decrease) of Gene_expression (expression) of Th1 in T cell associated with cytokine
9) Confidence 0.18 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.57 Pain Relevance 0.19
resulted in CD4+ T cell anergy [70], characterized by impaired differentiation that led to the absence of both Th1 and Th2 cytokine production.
Negative_regulation (absence) of Gene_expression (production) of Th1 in T cell associated with cytokine
10) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.37 Pain Relevance 0.12
Also the absence of CCR5 receptor in Plasmodium berghei ANKA-infected mouse brain resulted in a reduced Th1 cytokine production [9].
Negative_regulation (reduced) of Gene_expression (production) of Th1 in brain associated with cytokine
11) Confidence 0.16 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.64 Pain Relevance 0.29
Additionally, VIP shifts the immune response towards a Th2 pattern of cytokine secretion [17], which inhibits the production of inflammatory and Th1 cytokines [48].
Negative_regulation (inhibits) of Gene_expression (production) of Th1 associated with inflammation and cytokine
12) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.79 Pain Relevance 0.56
Depletion of Gr1+ cells during the early immune response results in reduced Th1 responses
Negative_regulation (reduced) of Gene_expression (responses) of Th1
13) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.66 Pain Relevance 0.03
stains of mice show that C57BL/6 mice are more prone to develop Th1 responses and
Negative_regulation (develop) of Gene_expression (responses) of Th1
14) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.91 Pain Relevance 0.10
Th1 polarization has been correlated with hyperleptinemia in hemodialysis patients [65] and the protection of ob/ob mice in Th1- as well as in Th2-dependent inflammation is provided by a decreased expression of the key transcription factors for Th1 and Th2 polarization, T-bet and GATA-3 in naive ob/ob T cells.
Negative_regulation (decreased) of Gene_expression (expression) of Th1 in T cells associated with inflammation and obesity
15) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.34 Pain Relevance 0.32
S├ęzary cells secrete Th2 cytokines, IL-4 and IL-10, causing loss of cellular immunity due to decreased production of Th1 cytokines, interferon gamma and interleukin 2 (IL-2) (Kim et al 2005).
Negative_regulation (decreased) of Gene_expression (production) of Th1 associated with cytokine
16) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.78 Pain Relevance 0.14
Clinical studies performed in patients with psoriasis showed that subcutaneous injections of IL-10 improved skin lesions and reduced the expression of Th1 cytokines (Asadullah et al 2003), thus suggesting an IL-10-induced shift from Th1 to Th2 immune response.
Negative_regulation (reduced) of Gene_expression (expression) of Th1 in skin associated with psoriasis and cytokine
17) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.26 Pain Relevance 0.45
The simple (visual) reaction time (SRT) for the left and right hand was also measured (young: left?
Negative_regulation (measured) of Gene_expression (left) of hand
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0.46 Pain Relevance 0
The simple (visual) reaction time (SRT) for the left and right hand was also measured (young: left?
Negative_regulation (measured) of Gene_expression (right) of hand
19) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0.45 Pain Relevance 0
In addition, significantly increased production of Th1-type/pro-inflammatory cytokines and chemokines, and conversely, reduced Th2-type cytokine production was observed in the lungs of protected mice.
Negative_regulation (reduced) of Gene_expression (production) of Th1-type in lungs associated with chemokine, inflammation and cytokine
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2731172 Disease Relevance 1.03 Pain Relevance 0.28

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