INT141276

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) DNA binding (Hand2) protein complex (Hand2)
cytoplasm (Il18) extracellular space (Il18) extracellular region (Il18)
Il18 (Mus musculus)
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 100.00 Very High Very High Very High
Neuritis 8 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 8 98.64 Very High Very High Very High
Immunization 2 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis.
Negative_regulation (deficiency) of IL-18 Negative_regulation (inhibits) of Gene_expression (production) of Th2 associated with experimental autoimmune neuritis, neuritis and cytokine
1) Confidence 0.25 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17218016 Disease Relevance 0.37 Pain Relevance 0.49
This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.
Negative_regulation (deficiency) of IL-18 Negative_regulation (inhibits) of Gene_expression (production) of Th2 associated with neuritis and cytokine
2) Confidence 0.21 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17218016 Disease Relevance 0.43 Pain Relevance 0.43

General Comments

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