INT141299

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Context Info
Confidence 0.55
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.38
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
vasculature 2
retinas 2
endothelial cell 2
brains 2
kidney 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
acular 50 99.88 Very High Very High Very High
aspirin 2 99.44 Very High Very High Very High
cINOD 16 99.18 Very High Very High Very High
Analgesic 39 98.28 Very High Very High Very High
Eae 22 97.32 Very High Very High Very High
Pain 89 90.64 High High
cytokine 8 83.64 Quite High
Inflammation 56 80.12 Quite High
Bioavailability 6 76.24 Quite High
alcohol 7 58.72 Quite High
Disease Link Frequency Relevance Heat
Hypertension 131 99.92 Very High Very High Very High
Targeted Disruption 22 99.78 Very High Very High Very High
Disease 100 99.28 Very High Very High Very High
Adhesions 32 98.28 Very High Very High Very High
Diabetes Mellitus 151 98.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

3 97.44 Very High Very High Very High
Inflammatory Pain 16 97.32 Very High Very High Very High
Apoptosis 31 96.56 Very High Very High Very High
Hyperglycemia 19 96.56 Very High Very High Very High
Stress 106 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down regulation of eNOS by NSAIDs, on the other hand, is in line with the suppression of eNOS expression by high-dose aspirin or meloxicam, in retinas of diabetic rats [36].
Negative_regulation (suppression) of Gene_expression (expression) of eNOS in retinas associated with aspirin, diabetes mellitus and cinod
1) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 0.54 Pain Relevance 0.91
However, the microarray results indicate that the downstream insulin receptor, as well as expression of endothelial NO synthase (eNos) was suppressed by the HF diet, what agree with the recent knowledge [34].
Negative_regulation (suppressed) of Gene_expression (expression) of endothelial NO synthase
2) Confidence 0.42 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.29 Pain Relevance 0.07
We also demonstrated that Tg2576 mice exhibit an increased phosphorylation of eNOS at serine 1177. eNOS expression has been shown to be decreased in the brains of AD patients [44].
Negative_regulation (decreased) of Gene_expression (expression) of eNOS in brains associated with disease
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.40 Pain Relevance 0
Further, ketorolac down-regulates eNOS gene expression.



Negative_regulation (regulates) of Gene_expression (expression) of eNOS gene associated with acular
4) Confidence 0.35 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2949722 Disease Relevance 0.24 Pain Relevance 0.76
It also suggests that androgens decrease the expression and activity of eNOS within the pulmonary vasculature.
Negative_regulation (decrease) of Gene_expression (expression) of eNOS in vasculature
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.49 Pain Relevance 0.03
Moreover, male androgen receptor knockout mice show decreased aortic eNOS expression and phosphorylated eNOS compared to wild type mice [28].
Negative_regulation (decreased) of Gene_expression (expression) of eNOS associated with targeted disruption
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.29 Pain Relevance 0
However, the microarray results indicate that the downstream insulin receptor, as well as expression of endothelial NO synthase (eNos) was suppressed by the HF diet, what agree with the recent knowledge [34].
Negative_regulation (suppressed) of Gene_expression (expression) of eNos
7) Confidence 0.30 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.29 Pain Relevance 0.07
Molecular changes were examined by assessing eNOS, iNOS, HO-1 and COX-2 expression in whole-kidney lysates by Western immunoblotting, and cellular colocalization of these enzymes was determined using immunofluorescence microscopy.
Spec (examined) Negative_regulation (assessing) of Gene_expression (expression) of eNOS in kidney
8) Confidence 0.28 Published 2007 Journal Nephron Exp. Nephrol. Section Body Doc Link 17220637 Disease Relevance 0 Pain Relevance 0
Ox-LDL trigger a variety of actions: they reduce eNOS (endothelial nitric oxide synthase) expression (Mehta and Li 2002) and further stimulate adhesion molecule expression (Libby 2002), apoptosis (Norata et al 2002), and release of proinflammatory prostaglandins (Norata, Pirillo, et al 2004) (Figure 1).
Negative_regulation (reduce) of Gene_expression (expression) of eNOS associated with apoptosis and adhesions
9) Confidence 0.21 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.17 Pain Relevance 0.16
Reduced expression of eNOS could be responsible for decreased NO production, but in most situations where endothelial dysfunction is encountered, the expression of eNOS is increased paradoxically, most likely because oxidative stress generates hydrogen peroxide, which increases the expression of the enzyme.
Negative_regulation (Reduced) of Gene_expression (expression) of eNOS associated with stress
10) Confidence 0.21 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.67 Pain Relevance 0.06
This uncoupling of eNOS plays an important role in endothelial cell dysfunction and increased oxidative stress. [47] Hyperglycemia and peroxynitrite (ONOO') also induce eNOS uncoupling with increases in O2' production. [48] Just published, Verma S and colleagues reported that CRP caused a marked down regulation of eNOS mRNA and protein expression with subsequent lower eNO production.
Negative_regulation (regulation) of Gene_expression (expression) of eNOS in endothelial cell associated with hyperglycemia and stress
11) Confidence 0.17 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.90 Pain Relevance 0.10

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