INT14131

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 34
Total Number 38
Disease Relevance 9.61
Pain Relevance 14.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
brain 4
neurons 2
coronary artery 1
pyramidal neurons 1
prefrontal 1
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 323 100.00 Very High Very High Very High
fluoxetine 248 100.00 Very High Very High Very High
agonist 190 100.00 Very High Very High Very High
Analgesic 40 100.00 Very High Very High Very High
Dopamine 29 100.00 Very High Very High Very High
sSRI 10 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
antidepressant 73 99.98 Very High Very High Very High
opioid receptor 3 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 3 99.86 Very High Very High Very High
Suicidal Behaviour 370 99.68 Very High Very High Very High
Depression 81 99.34 Very High Very High Very High
Headache 16 99.00 Very High Very High Very High
Pain 134 98.96 Very High Very High Very High
Shock 11 98.58 Very High Very High Very High
Congenital Anomalies 9 98.56 Very High Very High Very High
Targeted Disruption 22 98.40 Very High Very High Very High
Anxiety Disorder 131 97.80 Very High Very High Very High
Fibromyalgia 51 97.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differential regulation of 5-HT1A and 5-HT1B/D agonist responses by GDP suggests that different G-protein subtypes are involved upon 5-HT1A receptor activation by 5-HT1A and 5-HT1B/D agonists.
Regulation (regulation) of 5-HT1A associated with agonist
1) Confidence 0.60 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9650800 Disease Relevance 0 Pain Relevance 0.44
These results suggest that the effects of kappa opioids in the shock titration procedure probably involve serotonergic mechanisms that are modulated via 5-HT2 and, perhaps, 5-HT1A receptors.
Regulation (modulated) of 5-HT1A associated with shock and opioid
2) Confidence 0.60 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562503 Disease Relevance 0.68 Pain Relevance 0.75
Our data support hypothesis which indicate role of the 5-HT1A C(-1019)G SNP polymorphism in elevated risk of suicidal attempt.
Regulation (role) of 5-HT1A
3) Confidence 0.44 Published 2007 Journal Prz. Lek. Section Abstract Doc Link 17724868 Disease Relevance 0.57 Pain Relevance 0.38
The present study assessed the effects of concomitant administration of fluoxetine and a 5-HT1A receptor antagonist, pindolol, on focal hippocampal (HIP) seizures elicited by electrical stimulation in rats.
Regulation (effects) of 5-HT1A associated with convulsion, antagonist and fluoxetine
4) Confidence 0.44 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10400249 Disease Relevance 0.31 Pain Relevance 0.59
In the present study, the role of the 5-HT1A and 5-HT1B receptors in migraine was evaluated.
Regulation (role) of 5-HT1A associated with migraine
5) Confidence 0.44 Published 2007 Journal J Neural Transm Section Abstract Doc Link 17417740 Disease Relevance 0.44 Pain Relevance 0.26
We examined the effect of clinical doses of the SSRI, fluoxetine, on 5-HT1A receptor function in 15 normal volunteers.
Spec (examined) Regulation (effect) of 5-HT1A associated with ssri and fluoxetine
6) Confidence 0.44 Published 1999 Journal Neuropsychopharmacology Section Abstract Doc Link 10327431 Disease Relevance 0 Pain Relevance 0.64
This suggests that the agonistic action for 5-HT1A can be directly effective in migraine prophylaxis.
Regulation (effective) of 5-HT1A
7) Confidence 0.44 Published 2005 Journal Headache Section Body Doc Link 16109114 Disease Relevance 0 Pain Relevance 0
Possible mechanisms of action for the effects from serotonergic antidepressants involve 5-HT2 and 5-HT1A receptors, changes in extracellular brain serotonin concentrations, and changes in brain catecholamine systems.
Regulation (involve) of 5-HT1A in brain associated with antidepressant, catecholamine and serotonin
8) Confidence 0.44 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8726753 Disease Relevance 0 Pain Relevance 0.55
These data indicate that the mitogenic effect of 5-HT in SCLC cells involves both 5-HT1A and 5-HT1D receptor types.
Regulation (involves) of 5-HT1A associated with small cell lung cancer
9) Confidence 0.44 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566173 Disease Relevance 0.39 Pain Relevance 0.33
Using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (Kds) for 17 antidepressants and two of their metabolites at histamine H1, muscarinic, alpha 1-adrenergic, alpha 2-adrenergic, dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2 receptors.
Regulation (metabolites) of 5-HT1A in brain associated with dopamine, antidepressant and serotonin
10) Confidence 0.44 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7855217 Disease Relevance 0 Pain Relevance 0.50
In contrast, MK-212, which demonstrates an affinity for 5HT1A and 5HT2C receptor subtypes, and the 5HT1A receptor agonists ipsapirone or buspirone, have no effect on OC symptom intensity.
Regulation (affinity) of 5HT1A associated with agonist
11) Confidence 0.44 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.34 Pain Relevance 0.50
In radioligand binding studies on rat brain membranes, BRL 43694 had little or no affinity for 5-HT1A, 5-HT1B, 5-HT2 or for many other binding sites.
Neg (little) Regulation (affinity) of 5-HT1A in brain
12) Confidence 0.44 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2540014 Disease Relevance 0 Pain Relevance 0.13
The affinity for several other rat brain receptors such as 5-HT1A, alpha 2-adrenergic, dopamine D1, muscarinic M1 and M2, opiate sigma and beta 2-adrenergic was low.
Regulation (affinity) of 5-HT1A in brain associated with dopamine and opiate
13) Confidence 0.44 Published 1990 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2154737 Disease Relevance 0 Pain Relevance 0.29
Alcoholic suicides may fail to up-regulate ventral prefrontal 5-HT1A receptors in response to decreased serotonergic transmission increasing the risk of suicidal behavior.
Neg (fail) Regulation (regulate) of 5-HT1A in prefrontal associated with suicidal behaviour
14) Confidence 0.44 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872355 Disease Relevance 1.31 Pain Relevance 0.31
METHODS: We examined the effects of 5-hydroxytryptamine and a 5-hydroxytryptamine1-like receptor agonist sumatriptan on internal mammary artery segments (length, 3-4 mm) obtained from patients undergoing coronary artery bypass grafting.
Spec (examined) Regulation (effects) of 5-hydroxytryptamine1-like in coronary artery
15) Confidence 0.39 Published 1996 Journal Ann. Thorac. Surg. Section Body Doc Link 8893574 Disease Relevance 0 Pain Relevance 0
Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans.
Regulation (Effect) of 5-HT3 receptor in upper associated with agonist
16) Confidence 0.37 Published 2003 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 14616171 Disease Relevance 0.09 Pain Relevance 0.24
Previously we have shown that in vitro, 5HT1A receptor binding to a radioactive agonist can be modulated by specific intensity and frequency electromagnetic fields (EMFs).
Regulation (modulated) of 5HT1A associated with agonist
17) Confidence 0.35 Published 2003 Journal Biomed Sci Instrum Section Abstract Doc Link 12724937 Disease Relevance 0.59 Pain Relevance 0.50
One possible explanation for this finding is that fibromyalgia patients display perturbations in central sympathetic system with reduced reactivity, which might be due to reduced sensitivity of 5-HT1A receptors on sympathoexcitatory neurons in the rostral ventrolateral medulla.
Regulation (sensitivity) of 5-HT1A in neurons associated with rostral ventrolateral medulla and fibrositis
18) Confidence 0.26 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC113754 Disease Relevance 1.04 Pain Relevance 0.52
Modulation of 5-HT1A receptor-effector system function may be critical to the antidepressant/anti-OC efficacy of 5-HT reuptake inhibitors.
Regulation (Modulation) of 5-HT1A associated with antidepressant
19) Confidence 0.26 Published 1991 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1686817 Disease Relevance 0.32 Pain Relevance 0.60
Efficacy of the 5-HT1A agonist, buspirone hydrochloride, in migraineurs with anxiety: a randomized, prospective, parallel group, double-blind, placebo-controlled study.
Regulation (Efficacy) of 5-HT1A associated with anxiety disorder and agonist
20) Confidence 0.26 Published 2005 Journal Headache Section Title Doc Link 16109114 Disease Relevance 0.10 Pain Relevance 0.19

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