INT14132

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Context Info
Confidence 0.57
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 4.93
Pain Relevance 10.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
dendrites 1
dorsal 1
somatotrope 1
brain 1
synapse 1
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 75 99.96 Very High Very High Very High
antagonist 70 99.96 Very High Very High Very High
Opioid 3 99.92 Very High Very High Very High
sSRI 24 99.82 Very High Very High Very High
fluoxetine 135 99.78 Very High Very High Very High
Migraine 2 99.60 Very High Very High Very High
5HT 180 99.48 Very High Very High Very High
Pain 2 99.48 Very High Very High Very High
antidepressant 30 99.34 Very High Very High Very High
Serotonin 142 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 5 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Headache 2 99.60 Very High Very High Very High
Obsessive-compulsive Disorder 2 98.56 Very High Very High Very High
Premature Ejaculation 4 98.48 Very High Very High Very High
Cancer 3 98.40 Very High Very High Very High
Small Cell Lung Cancer 2 98.36 Very High Very High Very High
Neuropathic Pain 3 97.92 Very High Very High Very High
Treatment-resistant Depression (TRD) 5 95.48 Very High Very High Very High
Infection 13 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive-compulsive disorder.
Negative_regulation (decreases) of 5-HT1A associated with obsessive-compulsive disorder and fluoxetine
1) Confidence 0.57 Published 1991 Journal Psychopharmacology (Berl.) Section Title Doc Link 1686817 Disease Relevance 0.44 Pain Relevance 0.77
This effect may be mediated at the hypothalamic level via reduced 5-HT1A receptor function or at the pituitary level, either by a direct effect on somatotrope cells or via enhanced insulin-like growth factor-1 (IGF-1) or somatostatin (SS) release.
Negative_regulation (reduced) of 5-HT1A in somatotrope associated with somatostatin
2) Confidence 0.57 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11041314 Disease Relevance 0.09 Pain Relevance 0.23
A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors.
Negative_regulation (desensitization) of 5-HT1A
3) Confidence 0.57 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9316875 Disease Relevance 0 Pain Relevance 0.12
It is proposed that drug treatment of premature ejaculation should consist of 5-hydroxytryptamine (5-HT)2c receptor stimulation and/or 5-HT1A receptor inhibition.
Negative_regulation (inhibition) of 5-HT1A associated with premature ejaculation
4) Confidence 0.57 Published 2004 Journal Curr Opin Investig Drugs Section Abstract Doc Link 15298071 Disease Relevance 0.43 Pain Relevance 0.48
These results implicate the C(-1019)G 5-HT1A gene polymorphism as a potential marker for antidepressant response, suggesting a role for repression of the 5-HT1A gene.
Negative_regulation (repression) of 5-HT1A associated with antidepressant and repression
5) Confidence 0.57 Published 2004 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 15447813 Disease Relevance 0.48 Pain Relevance 0.58
The distribution of [125I]GTI sites was compared to that of [3H]5-HT binding sites (under so-called '5-HT1D conditions', i.e. in the presence of 100 nM 8-OH-DPAT and 100 nM mesulergine, in order to block 5-HT1A and 5-HT1C sites, respectively) in human and guinea-pig brain.
Negative_regulation (block) of 5-HT1A in brain
6) Confidence 0.57 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8164519 Disease Relevance 0.09 Pain Relevance 0.31
WAY-100635 given chronically in combination with fluoxetine blocked the SSRI-induced desensitization of the 5-HT1A receptor.
Negative_regulation (desensitization) of 5-HT1A associated with ssri and fluoxetine
7) Confidence 0.57 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 12095073 Disease Relevance 0.14 Pain Relevance 0.89
In rodents, treatment with NK1r antagonists has been shown to increase the firing of dorsal raphe nucleus (DRN) serotonin (5-hydroxytryptamine, 5-HT) neurons and to induce a desensitization of their 5-HT1A autoreceptors, suggesting local interactions between the SP and 5-HT systems.
Negative_regulation (desensitization) of 5-HT1A in dorsal associated with antagonist, serotonin, raphe and substance p
8) Confidence 0.42 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16819984 Disease Relevance 0.09 Pain Relevance 0.61
Chronic treatment with both drugs causes increases in extracellular 5-HT through 5-HT reuptake inhibition and desensitization of inhibitory 5-HT1A autoreceptors.
Negative_regulation (desensitization) of 5-HT1A
9) Confidence 0.42 Published 1996 Journal J Affect Disord Section Abstract Doc Link 8988452 Disease Relevance 0.66 Pain Relevance 0.77
Specific receptor subtypes have been associated with the suppression of cough at central sites, including 5-HT1A, opioid (mu, kappa, and delta), GABA-B, tachykinin neurokinin-1 (NK-1) and neurokinin-2, non-opioid (NOP-1), cannabinoid, dopaminergic, and sigma receptors.
Negative_regulation (suppression) of 5-HT1A associated with gaba, cannabinoid, cough and opioid
10) Confidence 0.42 Published 2009 Journal Handb Exp Pharmacol Section Abstract Doc Link 18825342 Disease Relevance 0.39 Pain Relevance 0.57
Although the authors observed a greater density of 5-HT1A receptor immunoreactivity in H-Agg hamsters within several areas, it appears to be related to a lack of serotonin release, as supported by further observations of decreased immunoreactive perikarya and 5-HT1A receptors in fluoxetine-treated hamsters.
Negative_regulation (decreased) of 5-HT1A associated with serotonin and fluoxetine
11) Confidence 0.42 Published 2009 Journal Behav. Neurosci. Section Abstract Doc Link 19485565 Disease Relevance 0.39 Pain Relevance 0.33
Furthermore, by downregulating 5HT1a autoreceptors and upregulating 5HT2a receptors, E2 increases the amount of serotonin found in the synapse and increases the amount available for postsynaptic transmission.
Negative_regulation (downregulating) of 5HT1a in synapse associated with serotonin
12) Confidence 0.41 Published 2010 Journal BMC Med Section Body Doc Link PMC3003619 Disease Relevance 0.33 Pain Relevance 0.38
These data indicate that the fluoxetine-induced adaptation was mediated by desensitization of the 5-HT1A receptor.
Negative_regulation (desensitization) of 5-HT1A associated with fluoxetine
13) Confidence 0.41 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 12095073 Disease Relevance 0.14 Pain Relevance 0.91
A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors.
Negative_regulation (reduction) of 5-HT1A
14) Confidence 0.41 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9316875 Disease Relevance 0 Pain Relevance 0.18
The intensity dependence of the cat AEP component with the highest functional similarity to this of the N1/P2-component in humans was significantly changed by influencing 5-HT1a and 5-HT2 receptors, but not 5-HT1c receptors.
Negative_regulation (influencing) of 5-HT1a associated with addiction
15) Confidence 0.41 Published 1997 Journal Biol. Psychiatry Section Abstract Doc Link 9171909 Disease Relevance 0 Pain Relevance 0.33
These findings constitute the first evidence of a reciprocal negative interference between human 5-HT1A and 5-HT1D receptors, and indicate that SCLC GLC-8 cells simultaneously express both receptor subtypes.
Negative_regulation (interference) of 5-HT1A associated with small cell lung cancer
16) Confidence 0.41 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016944 Disease Relevance 0.17 Pain Relevance 0.45
Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain?
Negative_regulation (injection) of 5HT3 receptor associated with pain, analgesic, antagonist and neuropathic pain
17) Confidence 0.38 Published 2003 Journal Anesth. Analg. Section Title Doc Link 14570668 Disease Relevance 0.42 Pain Relevance 0.79
Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633.
Negative_regulation (effects) of 5-HT1D receptor associated with analgesic, migraine and agonist
18) Confidence 0.24 Published 2002 Journal Cephalalgia Section Title Doc Link 12485205 Disease Relevance 0.24 Pain Relevance 1.00
We recently described the cloning of a fifth member of the 5-hydroxytryptamine (5-HT)1 (serotonin1) receptor class that inhibits adenylyl cyclase, namely the human 5-HT1F receptor (Adham et al. 1993a).
Negative_regulation (inhibits) of 5-HT1F receptor
19) Confidence 0.13 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8133900 Disease Relevance 0 Pain Relevance 0
Histamine may stimulate tumour growth through the histamine H2-receptor, while the dominant effect of 5-HT is 5-HT1-receptor inhibition. 10.
Negative_regulation (inhibition) of 5-HT1-receptor associated with cancer
20) Confidence 0.09 Published 1996 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8800567 Disease Relevance 0.33 Pain Relevance 0.39

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