INT141341

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.65
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
M cell 1
hippocampus 1
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 35 99.68 Very High Very High Very High
fibrosis 22 94.04 High High
anesthesia 5 76.44 Quite High
Inflammatory response 5 75.00 Quite High
Inflammatory mediators 2 65.04 Quite High
cytokine 2 57.72 Quite High
nMDA receptor 1 48.72 Quite Low
long-term potentiation 11 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Adhesions 2 95.80 Very High Very High Very High
Hemorrhagic Shock 13 95.04 Very High Very High Very High
Fibrosis 19 94.04 High High
Cardiovascular Disorder Under Development 3 86.08 High High
Heart Arrhythmia 16 85.04 High High
Aging 10 83.60 Quite High
Shock 24 77.88 Quite High
INFLAMMATION 9 75.00 Quite High
Stress 4 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Egr-1 DNA binding was assessed using the electrophoretic mobility shift assay.
Egr-1 Binding (binding) of
1) Confidence 0.48 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.44 Pain Relevance 0.21
Finally, Egr proteins also possess a domain for transcriptional repression mediated by the repressor proteins Nab1 and Nab2 that binds to and can repress Egr function (Russo et al., 1995; Svaren et al., 1996; Swirnoff et al., 1998).
Egr Binding (binds) of associated with repression
2) Confidence 0.37 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.15 Pain Relevance 0
Within this framework, it is possible that the absence of zif268 in the hippocampus was deleterious to a process of reconsolidation of the reactivated older representation.
zif268 Neg (absence) Binding (absence) of in hippocampus associated with hippocampus
3) Confidence 0.35 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.10
The transcription factors Atf3 and Egr1 were exclusively over-expressed in old Scn5a+/?
Egr1 Binding (over) of
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 1.05 Pain Relevance 0.33
Many of the identified cell cycle genes were found to be associated with G2/M cell cycle checkpoint/arrest including Fen1, Cdc25b, Mbd4, Egr1, Ccnb1, Ccnb2, Plk4, Aurka, and Mad2L1.
Egr1 Binding (associated) of in M cell
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.03

General Comments

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