INT141342

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.39
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
lens 2
lung 2
vein 2
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 99.16 Very High Very High Very High
cytokine 3 98.64 Very High Very High Very High
Hippocampus 25 89.40 High High
Inflammatory mediators 2 86.16 High High
Inflammatory response 8 75.00 Quite High
chemokine 6 73.68 Quite High
anesthesia 2 66.48 Quite High
depression 1 49.84 Quite Low
Dopamine 2 32.08 Quite Low
antagonist 1 27.32 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.16 Very High Very High Very High
Aids-related Complex 73 97.76 Very High Very High Very High
Hemorrhagic Shock 13 93.88 High High
Alzheimer's Dementia 1 86.56 High High
Adhesions 3 85.84 High High
Acute-phase Reaction 2 85.68 High High
Immune System Diseases 2 84.28 Quite High
Disease 11 82.40 Quite High
Sprains And Strains 54 81.12 Quite High
Shock 5 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Egr-1 mRNA expression diminished after 4 h of resuscitation, whereas Egr-1 protein expression and DNA binding activity persisted through resuscitation.
Negative_regulation (diminished) of Transcription (expression) of Egr-1
1) Confidence 0.43 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.34 Pain Relevance 0.24
In a similar vein, BDNF and zif268 mRNA expression were reported in the entorhinal and prefrontal cortices after object sampling, while in this experiment reactivation 9 days after training induced zif268 in entorhinal and somatosensory cortices and upon reactivation 21 days after training, BDNF and not zif268 was expressed in hippocampus and entorhinal and somatosensory cortices (Romero-Granados et al., 2010).
Negative_regulation (reported) of Transcription (expression) of zif268 in vein associated with hippocampus
2) Confidence 0.42 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.04
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Negative_regulation (downregulator) of Transcription (transcriptional) of EGR1 in lung associated with inflammation, aids-related complex and cytokine
3) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.04 Pain Relevance 0.17
Some of the early events—for example, ZENK expression changes—may persist after one day of lens treatment (ZENK mRNA level remains low after one day of negative lens treatment) or even reverse the direction of changes (ZENK mRNA levels are upregulated by short periods of positive lens wear [19] but seem to be downregulated by longer periods of positive lens treatment [41]).
Negative_regulation (downregulated) of Transcription (levels) of ZENK in lens
4) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0

General Comments

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