INT141344

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.59
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
lens 2
lung 1
vein 1
hippocampus 1
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 60 99.20 Very High Very High Very High
Inflammation 115 99.16 Very High Very High Very High
cytokine 19 99.04 Very High Very High Very High
Inflammatory mediators 4 85.28 High High
Inflammatory response 15 75.00 Quite High
chemokine 6 72.36 Quite High
anesthesia 6 70.92 Quite High
Dopamine 8 70.28 Quite High
depression 2 49.84 Quite Low
antagonist 2 27.32 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 130 99.16 Very High Very High Very High
Hemorrhagic Shock 26 99.16 Very High Very High Very High
Osteogenic Sarcomas 5 98.88 Very High Very High Very High
Anxiety Disorder 38 98.20 Very High Very High Very High
Thymoma 4 97.72 Very High Very High Very High
Aids-related Complex 75 97.10 Very High Very High Very High
Adhesions 10 90.28 High High
Crystal Associated Disease 124 88.72 High High
Alzheimer's Dementia 1 85.24 High High
Acute-phase Reaction 2 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a similar vein, BDNF and zif268 mRNA expression were reported in the entorhinal and prefrontal cortices after object sampling, while in this experiment reactivation 9 days after training induced zif268 in entorhinal and somatosensory cortices and upon reactivation 21 days after training, BDNF and not zif268 was expressed in hippocampus and entorhinal and somatosensory cortices (Romero-Granados et al., 2010).
Transcription (expression) of zif268 in vein associated with hippocampus
1) Confidence 0.70 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.04
However, dissociations have also been shown; for example, in a fear conditioning task, it was shown, using oligonucleotide antisense, that regulation of the transcription factor, Zif268/Egr1 in CA1 of the hippocampus was not necessary for consolidating fear memory, but was necessary for reconsolidation of the active memory (Lee et al., 2004).
Transcription (transcription) of Zif268 in hippocampus associated with anxiety disorder and hippocampus
2) Confidence 0.67 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.27 Pain Relevance 0.09
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Transcription (transcriptional) of EGR1 in lung associated with inflammation, aids-related complex and cytokine
3) Confidence 0.66 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.03 Pain Relevance 0.17
The Egr-1 mRNA expression diminished after 4 h of resuscitation, whereas Egr-1 protein expression and DNA binding activity persisted through resuscitation.
Transcription (expression) of Egr-1
4) Confidence 0.53 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.34 Pain Relevance 0.23
Hemorrhagic shock results in a rapid and transient hepatic expression of Egr-1 mRNA in WT mice by 1 h, whereas protein and DNA binding activity was evident by 2.5 h.
Transcription (expression) of Egr-1 associated with hemorrhagic shock
5) Confidence 0.53 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.40 Pain Relevance 0.23
In addition, Egr2 might have a more direct antagonistic function towards the transcriptional activity of the other Egr members.
Transcription (activity) of Egr
6) Confidence 0.46 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.19 Pain Relevance 0
Brand et al. [28] found significant changes in the mRNA concentration of Egr1, the Finkel-Biskis-Jinkins osteosarcoma oncogene (Fos), thymoma viral oncogene homolog 2, and others in response to the treatment of mice with diffusers.
Transcription (concentration) of Egr1 associated with thymoma and osteogenic sarcomas
7) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0.31 Pain Relevance 0.04
Some of the early events—for example, ZENK expression changes—may persist after one day of lens treatment (ZENK mRNA level remains low after one day of negative lens treatment) or even reverse the direction of changes (ZENK mRNA levels are upregulated by short periods of positive lens wear [19] but seem to be downregulated by longer periods of positive lens treatment [41]).
Transcription (levels) of ZENK in lens
8) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0
Some of the early events—for example, ZENK expression changes—may persist after one day of lens treatment (ZENK mRNA level remains low after one day of negative lens treatment) or even reverse the direction of changes (ZENK mRNA levels are upregulated by short periods of positive lens wear [19] but seem to be downregulated by longer periods of positive lens treatment [41]).
Transcription (level) of ZENK in lens
9) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0
For example, the concentration of the mRNA of the transcription factor ZENK is changed already after 15–30 min [18-20].
Transcription (concentration) of ZENK
10) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0
We observed an early, steep rise in proinflammatory cytokine mRNA synthesis that essentially paralleled the synthesis of mRNA encoding the immediate early transcription factor Egr-1.
Transcription (synthesis) of Egr-1 associated with cytokine
11) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.52 Pain Relevance 0.27
We observed an early, steep rise in proinflammatory cytokine mRNA synthesis that essentially paralleled the synthesis of mRNA encoding the immediate early transcription factor Egr-1.
Transcription (synthesis) of Egr-1 associated with cytokine
12) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.52 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox