INT141360

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (AP1B1) cytosol (AP1B1) Golgi apparatus (AP1B1)
Anatomy Link Frequency
spinal 1
AP1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 97.80 Very High Very High Very High
tolerance 6 96.12 Very High Very High Very High
Morphine 11 95.72 Very High Very High Very High
Endogenous opioid 1 94.24 High High
medulla 5 93.24 High High
intrathecal 2 92.04 High High
tail-flick 1 78.08 Quite High
antinociception 1 48.00 Quite Low
Hyperalgesia 1 42.40 Quite Low
opioid receptor 1 35.12 Quite Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 62 50.00 Quite Low
Stress 3 48.32 Quite Low
Hyperalgesia 1 42.40 Quite Low
Apoptosis 4 8.40 Low Low
Dementia 15 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Spinal Muscular Atrophy 7 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Fasciculation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, many of the adaptor-related protein complex transcripts are strongly downregulated, AP1B1 (?
Negative_regulation (downregulated) of AP1B1
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0 Pain Relevance 0
The present study determined the effects of BAM8-22, a derivative of BAM22 and selective sensory neuron-specific receptor (SNSR) agonist, on the development and maintenance of tolerance to spinal morphine.
Negative_regulation (derivative) of BAM22 in spinal associated with tolerance, agonist and morphine
2) Confidence 0.02 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17227682 Disease Relevance 0 Pain Relevance 1.06

General Comments

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