INT141367

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.07
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
plasma 4
T-cell 4
B-cells 2
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 24 99.98 Very High Very High Very High
Opioid 4 99.68 Very High Very High Very High
cytokine 3 97.92 Very High Very High Very High
antagonist 2 97.48 Very High Very High Very High
opioid receptor 7 96.68 Very High Very High Very High
corticosteroid 8 93.08 High High
mu opioid receptor 2 92.04 High High
Inflammation 14 89.60 High High
Enkephalin 1 73.04 Quite High
Kappa opioid receptor 1 50.80 Quite High
Disease Link Frequency Relevance Heat
Eczema 54 98.44 Very High Very High Very High
Disease 32 89.68 High High
INFLAMMATION 14 89.60 High High
Recurrence 4 89.04 High High
Organ Transplantation 17 88.24 High High
Syndrome 1 81.96 Quite High
Contact Dermatitis 1 81.16 Quite High
Telangiectasia 3 80.36 Quite High
Frailty 13 79.36 Quite High
Liver Failure 3 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that different extracts inhibited T-cell blastogenesis and IL-2 mRNA expression.
Negative_regulation (inhibited) of Transcription (expression) of IL-2 in T-cell
1) Confidence 0.32 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2955679 Disease Relevance 0 Pain Relevance 0
Further advancement was achieved by the discovery and the use of agents such as Tacrolimus which inhibits T-lymphocyte signal transduction and interleukin-2 transcription, and Sirolimus which inhibits the response to interleukin-2 thereby blocking the activation of T- and B-cells.


Negative_regulation (inhibits) of Transcription (transcription) of interleukin-2 in B-cells
2) Confidence 0.27 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2703995 Disease Relevance 0.93 Pain Relevance 0.08
CD3/28 mAb-induced interleukin-2 transcription was also inhibited by the opioids fentanyl and loperamide.
Negative_regulation (inhibited) of Transcription (transcription) of interleukin-2 associated with opioid
3) Confidence 0.19 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18463202 Disease Relevance 0 Pain Relevance 0.94
Chronic morphine inhibits interleukin-2 (IL-2) at both the transcriptional and protein synthesis levels.
Negative_regulation (inhibits) of Transcription (transcriptional) of interleukin-2 associated with morphine
4) Confidence 0.15 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.35
This leads to the uncoupling of CBP/p300 thereby abrogating IL-2 transcription.
Negative_regulation (abrogating) of Transcription (transcription) of IL-2
5) Confidence 0.15 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.55
Chronic morphine inhibits interleukin-2 (IL-2) at both the transcriptional and protein synthesis levels.
Negative_regulation (inhibits) of Transcription (transcriptional) of IL-2 associated with morphine
6) Confidence 0.15 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.35
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.
Negative_regulation (relative) of Transcription (expression) of interleukin-2 in plasma
7) Confidence 0.08 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.09 Pain Relevance 0
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.
Negative_regulation (relative) of Transcription (expression) of IL-2 in plasma
8) Confidence 0.08 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.09 Pain Relevance 0
Inhibition of calcineurin results in decreased transcription of IL-2, with resulting decreases in T-cell activation and cytokine production.
Negative_regulation (decreased) of Transcription (transcription) of IL-2 in T-cell associated with cytokine
9) Confidence 0.02 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770385 Disease Relevance 0.96 Pain Relevance 0.15

General Comments

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