INT14137

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 56
Total Number 58
Disease Relevance 2.88
Pain Relevance 36.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
cortex 5
spinal cord 5
brain 4
dorsal horn 4
central nervous system 3
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 121 100.00 Very High Very High Very High
mu opioid receptor 69 100.00 Very High Very High Very High
Opioid 68 100.00 Very High Very High Very High
Enkephalin 63 100.00 Very High Very High Very High
Spinal cord 48 100.00 Very High Very High Very High
agonist 33 100.00 Very High Very High Very High
Pain 28 100.00 Very High Very High Very High
Hippocampus 19 100.00 Very High Very High Very High
Cholecystokinin 17 100.00 Very High Very High Very High
adenocard 8 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 5 99.52 Very High Very High Very High
Low Back Pain 1 99.20 Very High Very High Very High
Pain 10 97.76 Very High Very High Very High
INFLAMMATION 5 97.52 Very High Very High Very High
Nociception 12 97.48 Very High Very High Very High
Convulsion 1 89.28 High High
Diabetes Mellitus 6 88.44 High High
Dyskinesias 34 88.32 High High
Targeted Disruption 1 88.08 High High
Epilepsy 1 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a combination of radioactive and non-radioactive in situ hybridization, the mu opioid receptor mRNA was localized in enkephalin as well as dynorphin neurones of the rat striatum.
Localization (localized) of mu opioid receptor mRNA in striatum associated with dynorphin, mu opioid receptor and enkephalin
1) Confidence 0.81 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930971 Disease Relevance 0 Pain Relevance 0.64
Co-localization of mu opioid receptor is greater with dynorphin than enkephalin in rat striatum.
Localization (Co-localization) of mu opioid receptor in striatum associated with dynorphin, mu opioid receptor and enkephalin
2) Confidence 0.81 Published 1996 Journal Neuroreport Section Title Doc Link 8930971 Disease Relevance 0 Pain Relevance 0.97
Presynaptic localization of the carboxy-terminus epitopes of the mu opioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord.
Localization (localization) of mu opioid receptor in spinal cord associated with nociceptor, mu opioid receptor and spinal cord
3) Confidence 0.79 Published 2001 Journal Neuroscience Section Title Doc Link 11682168 Disease Relevance 0.27 Pain Relevance 1.08
Colocalization of the mu-opioid receptor and calcium/calmodulin-dependent kinase II in distinct pain-processing brain regions.
Localization (Colocalization) of mu-opioid receptor in brain associated with pain, opioid receptor and immobilon
4) Confidence 0.78 Published 2000 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11146127 Disease Relevance 0.15 Pain Relevance 1.16
Differences in mu-receptor mRNA and receptor binding distributions were observed in several regions, including the olfactory bulb, cortex, hippocampus, superior colliculus, spinal trigeminal nucleus, cochlear nucleus and spinal cord, and may be due to mu-receptor transport to presynaptic terminals.
Localization (transport) of mu-receptor in spinal cord associated with hippocampus and spinal cord
5) Confidence 0.75 Published 1994 Journal Brain Res. Section Abstract Doc Link 8032920 Disease Relevance 0 Pain Relevance 0.43
Differences in mu-receptor mRNA and receptor binding distributions were observed in several regions, including the olfactory bulb, cortex, hippocampus, superior colliculus, spinal trigeminal nucleus, cochlear nucleus and spinal cord, and may be due to mu-receptor transport to presynaptic terminals.
Localization (transport) of mu-receptor in spinal cord associated with hippocampus and spinal cord
6) Confidence 0.75 Published 1994 Journal Brain Res. Section Abstract Doc Link 8032920 Disease Relevance 0 Pain Relevance 0.38
CONCLUSIONS: Ethanol-induced facilitation of social play behavior seen in adolescent animals is mediated in part through ethanol-induced release of endogenous ligands for the mu-opioid receptor or an ethanol-associated enhancement of sensitivity of these receptors for their endogenous ligands.


Localization (release) of mu-opioid receptor
7) Confidence 0.75 Published 2009 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 19302088 Disease Relevance 0 Pain Relevance 0
Presynaptic localization of the carboxy-terminus epitopes of the mu opioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord.
Localization (localization) of MOR-1D in spinal cord associated with nociceptor, mu opioid receptor and spinal cord
8) Confidence 0.74 Published 2001 Journal Neuroscience Section Title Doc Link 11682168 Disease Relevance 0.27 Pain Relevance 1.10
Together, this evidence suggests that alpha(2A)-AR and muOR may be colocalized within many of the same neuronal profiles in both the intermediate and caudal mNTS.
Localization (colocalized) of muOR in neuronal
9) Confidence 0.72 Published 2002 Journal Synapse Section Abstract Doc Link 11793427 Disease Relevance 0 Pain Relevance 0.34
The co-localization of oxytocin and mu-opioid receptor in neurons within the SON was observed with the double-labeled methods of in situ hybridization combined with immunohistochemistry.
Localization (co-localization) of mu-opioid receptor in neurons associated with opioid receptor
10) Confidence 0.72 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11172938 Disease Relevance 0 Pain Relevance 0.62
This "subthreshold" current was used to determine the ability of mu opioid receptor (microR) agonists to alter VP responses to endogenous (released by electrical activation of afferents) and exogenous (iontophoretically applied) transmitters. microR agonists decreased the variability and enhanced the acuity (e.g., "signal-to-noise" relationship) of VP responses to activation of glutamatergic inputs from the prefrontal cortex and amygdala.
Localization (released) of mu opioid receptor in cortex associated with agonist, mu opioid receptor and amygdala
11) Confidence 0.71 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415650 Disease Relevance 0 Pain Relevance 0.91
Presynaptic localization of the carboxy-terminus epitopes of the mu opioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord.
Localization (localization) of MOR-1C in spinal cord associated with nociceptor, mu opioid receptor and spinal cord
12) Confidence 0.69 Published 2001 Journal Neuroscience Section Title Doc Link 11682168 Disease Relevance 0.27 Pain Relevance 1.09
Within dual-labeled profiles, the intracellular distribution of alpha(2A)-AR and muOR differed.
Localization (distribution) of muOR
13) Confidence 0.68 Published 2002 Journal Synapse Section Abstract Doc Link 11793427 Disease Relevance 0 Pain Relevance 0.25
Confocal microscopy of rat brain sections double-labelled with anti-mu opioid receptor and anti-GIRK1 antibodies revealed colocalization of GIRK1 and mu opioid receptor immunoreactivities in somata of subpopulations of neurons in the cerebral cortex, anterior olfactory nucleus, nucleus accumbens, globus pallidus, substantia nigra, peripeduncular nucleus, hippocampal formation, diagonal band, thalamus, locus coeruleus, dorsal raphe, red nucleus, nucleus of the trapezoid body, reticular nucleus, vestibular nucleus, inferior colliculus and the mesencephalic trigeminal nucleus.
Localization (colocalization) of mu opioid receptor in trapezoid associated with nucleus accumbens, locus ceruleus, substantia nigra, mu opioid receptor, thalamus, raphe and cerebral cortex
14) Confidence 0.67 Published 1995 Journal Recept. Channels Section Abstract Doc Link 8821795 Disease Relevance 0 Pain Relevance 0.66
DAMGO stimulated [35S]GTP-gamma-S binding with an anatomical specificity consistent with the localization of mu opioid receptors.
Localization (localization) of mu opioid associated with mu opioid receptor
15) Confidence 0.66 Published 1997 Journal Synapse Section Abstract Doc Link 9329153 Disease Relevance 0 Pain Relevance 0.56
CB1-cannabinoid and mu-opioid receptor co-localization on postsynaptic target in the rat dorsal horn.
Localization (co-localization) of mu-opioid receptor in dorsal horn associated with cannabinoid, dorsal horn and opioid receptor
16) Confidence 0.64 Published 2001 Journal Neuroreport Section Title Doc Link 11726775 Disease Relevance 0.10 Pain Relevance 1.05
mu-Opioid receptor mRNA expression and immunohistochemical localization in the rat temporomandibular joint.
Localization (localization) of mu-Opioid receptor in temporomandibular joint associated with snapping jaw and opioid receptor
17) Confidence 0.62 Published 2002 Journal Peptides Section Title Doc Link 12084519 Disease Relevance 0.35 Pain Relevance 0.97
Postsynaptic mu-opioid receptor response in the median preoptic nucleus is altered by a systemic sodium challenge in rats.
Localization (response) of mu-opioid receptor in nucleus associated with opioid receptor
18) Confidence 0.62 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18364037 Disease Relevance 0 Pain Relevance 0.37
The aim of the current study was to examine whether there were changes in the localization and density of micro-opioid receptor subtype (MOR1) and GABA in the visual cortex of morphine-dependent and abstinent rats.
Localization (localization) of MOR1 in cortex associated with gaba, opioid receptor and morphine
19) Confidence 0.61 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17950530 Disease Relevance 0 Pain Relevance 0.69
Endomorphin-1 is a short-chain neuropeptide with a high affinity fo the mu-opioid receptor and has recently been localized in acutely inflamed knee joints where it was found to reduce inflammation.
Localization (localized) of mu-opioid receptor in knee joints associated with inflammation, neuropeptide and opioid receptor
20) Confidence 0.58 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670807 Disease Relevance 0.10 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox