INT141385

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.95
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RX7) cytoplasm (P2RX7)
Anatomy Link Frequency
macrophages 5
microglial cells 3
spinal 2
P2RX7 (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 8 99.24 Very High Very High Very High
Inflammation 124 97.92 Very High Very High Very High
antagonist 29 94.36 High High
Peripheral nerve injury 5 94.24 High High
Pain 95 90.08 High High
glial activation 4 88.92 High High
agonist 55 87.92 High High
Multiple sclerosis 98 84.72 Quite High
Lasting pain 26 83.04 Quite High
Inflammatory mediators 9 81.36 Quite High
Disease Link Frequency Relevance Heat
Infection 70 99.78 Very High Very High Very High
Death 37 99.24 Very High Very High Very High
Neuropathic Pain 26 99.24 Very High Very High Very High
INFLAMMATION 151 97.92 Very High Very High Very High
Nervous System Injury 15 93.80 High High
Disease 49 89.64 High High
Mycobacterial Infection 24 89.44 High High
Sprains And Strains 10 88.68 High High
Apoptosis 23 88.28 High High
Motor Neuron Diseases 88 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Substance P receptor expression in human pulp tissue is significantly increased during inflammatory phenomena such as acute irreversible pulpitis.


Positive_regulation (increased) of Gene_expression (expression) of P receptor
1) Confidence 0.62 Published 2007 Journal Int Endod J Section Body Doc Link 17229115 Disease Relevance 0.11 Pain Relevance 0
Thus, despite the production of ecto-ATPases by Leishmania [16], this strategy is not sufficient to protect the host cell against the infection-dependent upregulation in P2X7 expression.
Positive_regulation (upregulation) of Gene_expression (expression) of P2X7 associated with infection
2) Confidence 0.45 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 0.71 Pain Relevance 0
release; previously, work performed predominantly in macrophages had not reported any P2X7 receptor-independent production of IL-1?
Neg (independent) Positive_regulation (independent) of Gene_expression (production) of P2X7 in macrophages
3) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.03
Increased P2X7 expression has been found in peripheral macrophages following inflammation but this receptor is also expressed in spinal neurones and microglia following peripheral nerve injury [107].
Positive_regulation (Increased) of Gene_expression (expression) of P2X7 in spinal associated with nervous system injury, inflammation and peripheral nerve injury
4) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.09 Pain Relevance 1.20
Experiments using macrophages derived from P2X7-deficient mice revealed that ATPe stimulates the production of reactive species such as RNIs equally well in both wildtype and P2X7-deficient macrophages [11].
Positive_regulation (stimulates) of Gene_expression (production) of P2X7 in macrophages
5) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 0.58 Pain Relevance 0.04
A cascade may be postulated – cell death raises extracellular ATP [40], which activates P2X7 expressed by microglial cells/macrophages; the latter release IL1?
Positive_regulation (activates) of Gene_expression (expressed) of P2X7 in microglial cells associated with death
6) Confidence 0.29 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.73 Pain Relevance 0.23
A cascade may be postulated – cell death raises extracellular ATP [40], which activates P2X7 expressed by microglial cells/macrophages; the latter release IL1?
Positive_regulation (activates) of in macrophages Gene_expression (expressed) of P2X7 in microglial cells associated with death
7) Confidence 0.10 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.73 Pain Relevance 0.23

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