INT1414

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Context Info
Confidence 0.62
First Reported 1977
Last Reported 2009
Negated 11
Speculated 31
Reported most in Abstract
Documents 169
Total Number 200
Disease Relevance 32.05
Pain Relevance 139.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 10
spinal cord 8
neurons 6
hypothalamus 4
plasma 4
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 378 100.00 Very High Very High Very High
opiate 311 100.00 Very High Very High Very High
Morphine 245 100.00 Very High Very High Very High
Kappa opioid receptor 230 100.00 Very High Very High Very High
narcan 191 100.00 Very High Very High Very High
antagonist 181 100.00 Very High Very High Very High
opioid receptor 180 100.00 Very High Very High Very High
Opioid 174 100.00 Very High Very High Very High
Enkephalin 122 100.00 Very High Very High Very High
cocaine 121 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 52 100.00 Very High Very High Very High
INFLAMMATION 25 100.00 Very High Very High Very High
Hyperalgesia 14 100.00 Very High Very High Very High
Diuresis 13 99.96 Very High Very High Very High
Depression 9 99.92 Very High Very High Very High
Cognitive Disorder 4 99.84 Very High Very High Very High
Hypertension 16 99.78 Very High Very High Very High
Bordatella Infection 5 99.72 Very High Very High Very High
Neuroblastoma 9 99.52 Very High Very High Very High
Pain 22 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of body weight (index of opiate dependence) was not observed either 24 h or 48 h after the last morphine administration. mu- and kappa-opioid receptor density and affinity were not affected by repeated morphine administrations at either dose.
Neg (not) Regulation (affected) of kappa-opioid receptor in body associated with addiction, body weight, kappa opioid receptor, opiate and morphine
1) Confidence 0.62 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9151297 Disease Relevance 0.20 Pain Relevance 1.79
This study does not support a role for opiate receptor regulation of the duration of sleeping time.
Regulation (regulation) of opiate receptor associated with opiate
2) Confidence 0.62 Published 1982 Journal Anesthesiology Section Abstract Doc Link 6121523 Disease Relevance 0.09 Pain Relevance 0.79
Estrogen and progesterone regulate opiate receptor densities in multiple brain regions.
Regulation (regulate) of opiate receptor in brain associated with narcan and opiate
3) Confidence 0.62 Published 1990 Journal Endocrinology Section Title Doc Link 2153527 Disease Relevance 0 Pain Relevance 0.68
In the present study, we investigated the influence of intrathecal (i.t.) administration of morphine and endomorphin-1 on the level of pronociceptin/orphanin FQ and opioid receptor-like 1 (ORL1) receptor mRNAs in the lumbar part of the spinal cord in the rat model of neuropathic pain.
Spec (investigated) Regulation (influence) of ORL1 in spinal cord associated with orphanin, neuropathic pain, opioid receptor, spinal cord, morphine and intrathecal
4) Confidence 0.61 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159147 Disease Relevance 0.36 Pain Relevance 0.94
Changes in kappa-opioid receptor levels have been implicated in the development of physical dependence upon and withdrawal from the mixed agonist-antagonist opioid, butorphanol.
Regulation (Changes) of kappa-opioid receptor associated with physical dependence, antagonist, butorphanol, agonist, kappa opioid receptor, opioid and withdrawal
5) Confidence 0.61 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580956 Disease Relevance 0.25 Pain Relevance 1.23
No significant changes on the mu-, delta- and kappa-opioid receptor immunoreactivities were observed after 6-hydroxydopamine treatment in either Freund's adjuvant-treated or non-treated rats.
Neg (No) Regulation (changes) of kappa-opioid receptor associated with kappa opioid receptor
6) Confidence 0.60 Published 1998 Journal Neuroscience Section Abstract Doc Link 9607719 Disease Relevance 0.38 Pain Relevance 0.97
Longer durations of morphine treatment (PD 1-8) did not show these alterations in mu opiate receptor density.
Neg (not) Regulation (alterations) of mu opiate receptor associated with opioid receptor 1 and morphine
7) Confidence 0.60 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1664787 Disease Relevance 0 Pain Relevance 0.89
The results also suggest that postreceptor components are important in regulating the kappa receptor function following prolonged opiate exposure.
Regulation (regulating) of kappa receptor associated with opiate
8) Confidence 0.58 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.17 Pain Relevance 1.10
We investigated whether acute treatment with agonists affected the subcellular distribution of kappa opioid receptor (KOPR) in the dorsal horn of the rat lumbar spinal cord by using immunoelectron microscopy.
Spec (whether) Regulation (affected) of kappa opioid receptor in spinal cord associated with dorsal horn, kappa opioid receptor, agonist and spinal cord
9) Confidence 0.58 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19130621 Disease Relevance 0 Pain Relevance 0.55
This study reports on the molecular mechanism of delta-opiate receptor down regulation on 108CC15 neuroblastoma X glioma hybrid cells.
Regulation (regulation) of delta-opiate receptor associated with neuroblastoma, opiate and glioma
10) Confidence 0.57 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6324048 Disease Relevance 0.20 Pain Relevance 0.26
The present experiments examined whether OFQ/N in the VMH facilitates lordosis behavior in estrogen-primed, sexually unreceptive female rats, and whether estrogen regulates ORL-1 levels in the VMH.
Spec (whether) Regulation (regulates) of ORL-1 in VMH associated with lordosis
11) Confidence 0.54 Published 1997 Journal Neuroreport Section Abstract Doc Link 9462455 Disease Relevance 0.26 Pain Relevance 0.29
Changes in the brain kappa-opioid receptor levels of rats in withdrawal from physical dependence upon butorphanol.
Regulation (Changes) of kappa-opioid receptor in brain associated with physical dependence, narcan, butorphanol, kappa opioid receptor and withdrawal
12) Confidence 0.53 Published 2003 Journal Neuroscience Section Title Doc Link 14580956 Disease Relevance 0.28 Pain Relevance 1.82
Effects of the opioid receptor like-1 (ORL-1) receptor agonist Ro 64-6198 (0.1, 0.3, and 1.0 mg/kg intraperitoneally (i.p.)) on operant ethanol self-administration and activation of self-administration by ethanol deprivation were studied in male Wistar rats.
Regulation (Effects) of opioid receptor like-1 associated with agonist and opioid receptor
13) Confidence 0.45 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16880770 Disease Relevance 0.07 Pain Relevance 0.40
Effect of kappa-opioid receptor agonists on morphine analgesia in morphine-naive and morphine-tolerant rats.
Regulation (Effect) of kappa-opioid receptor associated with agonist, kappa opioid receptor, analgesia and morphine
14) Confidence 0.45 Published 1988 Journal Eur. J. Pharmacol. Section Title Doc Link 2853674 Disease Relevance 0 Pain Relevance 2.34
Behavioral effects of kappa-opioid-receptor stimulation on neonatal rats.
Regulation (effects) of kappa-opioid-receptor associated with analgesic and opioid
15) Confidence 0.45 Published 1994 Journal Behav. Neurosci. Section Title Doc Link 8037885 Disease Relevance 0.16 Pain Relevance 1.09
Regional changes in the mRNA for and protein levels of the kappa-opioid receptor focus attention on highly special roles for this receptor in the development of physical dependence on and the expression of withdrawal from butorphanol dependence.
Regulation (changes) of kappa-opioid receptor associated with addiction, physical dependence, butorphanol, kappa opioid receptor and withdrawal
16) Confidence 0.45 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16130146 Disease Relevance 0.16 Pain Relevance 1.38
The behavioral effects of the kappa-opioid receptor agonist U69593 were examined in lactating rats.
Regulation (effects) of kappa-opioid receptor associated with agonist and kappa opioid receptor
17) Confidence 0.45 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18514802 Disease Relevance 0 Pain Relevance 0.40
The effects of a kappa-opioid receptor agonist on acute amphetamine-induced behavioral activation and dialysate levels of dopamine and glutamate in the ventral striatum were investigated.
Spec (investigated) Regulation (effects) of kappa-opioid receptor in striatum associated with glutamate, dopamine, agonist and kappa opioid receptor
18) Confidence 0.45 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461896 Disease Relevance 0 Pain Relevance 0.55
Effects of the kappa-opioid receptor agonist U-50,488 on morphine-induced place preference conditioning in the developing rat.
Regulation (Effects) of kappa-opioid receptor associated with analgesic, agonist, kappa opioid receptor and morphine
19) Confidence 0.45 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8982712 Disease Relevance 0 Pain Relevance 0.73
[Effect of opiate receptor agonists and antagonists on maternal aggression in rats].
Regulation ([Effect) of opiate receptor associated with antagonist, aggression, narcan, agonist and opiate
20) Confidence 0.45 Published 1989 Journal Biull Eksp Biol Med Section Title Doc Link 2538171 Disease Relevance 0.28 Pain Relevance 0.75

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