INT141426

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.11

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1) nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)

ANTXRL (Homo sapiens) ADCY1 (Homo sapiens)

Pain Link Frequency Relevance Heat mu opioid receptor 1 99.64 opioid receptor 2 67.44 MU agonist 1 47.28 Enkephalin 1 43.92 Potency 1 34.00 Opioid 1 25.00

Disease Link Frequency Relevance Heat Bordatella Infection 4 100.00 Glioma 1 70.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chronic activation of mu-opioid receptors, which couple to pertussis toxin-sensitive Galphai/o proteins to inhibit adenylyl cyclase (AC), leads to a compensatory sensitization of AC.

pertussis toxin Negative_regulation (inhibit) of cyclase associated with bordatella infection and mu opioid receptor

1) Confidence 0.00 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 17230639 Disease Relevance 0.41 Pain Relevance 0.11

General Comments

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