INT141443

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Context Info
Confidence 0.82
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.39
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
sciatic nerves 4
perineurium 1
Cav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 25 99.84 Very High Very High Very High
Sciatic nerve 30 99.68 Very High Very High Very High
Neuritis 40 98.36 Very High Very High Very High
addiction 6 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 40 98.36 Very High Very High Very High
Disease 3 96.32 Very High Very High Very High
Immunization 5 95.48 Very High Very High Very High
Apoptosis 5 94.08 High High
Death 5 92.20 High High
Channelopathies 8 36.72 Quite Low
Cytomegalovirus Infection 1 24.08 Low Low
Syndrome 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased phosphorylation of caveolin-1 in the sciatic nerves of Lewis rats with experimental autoimmune neuritis.
Phosphorylation (phosphorylation) of caveolin-1 in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
1) Confidence 0.82 Published 2007 Journal Brain Res. Section Title Doc Link 17234162 Disease Relevance 0.93 Pain Relevance 0.86
Based on these findings, we postulate that caveolin-1 is phosphorylated in inflammatory cells soon after they infiltrate the sciatic nerve, as well as in the perineurium, and that p-caveolin-1 activates intracellular signaling in inflammatory cells, leading to cell death, which ultimately eliminates the infiltrating inflammatory cells from the sciatic nerves of animals with EAN.
Phosphorylation (phosphorylated) of caveolin-1 in perineurium associated with inflammation, sciatic nerve, neuritis and death
2) Confidence 0.82 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 1.29 Pain Relevance 1.04
Western blot analysis showed that the phosphorylation of caveolin-1 increased significantly in the sciatic nerves of EAN-affected rats at the paralytic stage of EAN on day 14 post-immunization (PI) (P<0.05) and declined slightly thereafter during the recovery stage.
Phosphorylation (phosphorylation) of caveolin-1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
3) Confidence 0.82 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 0.82 Pain Relevance 0.82
The levels of phosphorylated caveolin-1 (p-caveolin-1) were analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN).
Phosphorylation (phosphorylated) of phosphorylated caveolin-1 in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
4) Confidence 0.71 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 0.62 Pain Relevance 0.64
The levels of phosphorylated caveolin-1 (p-caveolin-1) were analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN).
Phosphorylation (phosphorylated) of p-caveolin-1 in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
5) Confidence 0.71 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 0.63 Pain Relevance 0.65
Point mutations of CaV1.3 (?
Phosphorylation (mutations) of CaV1
6) Confidence 0.25 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.10 Pain Relevance 0

General Comments

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