INT141458

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Anatomy Link Frequency
lungs 2
peripheral nerve 1
dorsal root ganglion 1
Adora2a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 2 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
dorsal root ganglion 1 100.00 Very High Very High Very High
Peripheral nerve injury 1 99.84 Very High Very High Very High
Neuropathic pain 1 97.84 Very High Very High Very High
agonist 21 84.84 Quite High
adenocard 36 80.28 Quite High
Pain 3 75.00 Quite High
Antinociceptive 1 54.72 Quite High
Inflammation 62 51.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 100.00 Very High Very High Very High
Nervous System Injury 1 99.40 Very High Very High Very High
Neuropathic Pain 1 97.84 Very High Very High Very High
Targeted Disruption 2 76.48 Quite High
Pain 2 75.00 Quite High
Lung Injury 35 66.00 Quite High
INFLAMMATION 51 51.84 Quite High
Adult Respiratory Distress Syndrome 19 50.20 Quite High
Hypoxia 66 31.92 Quite Low
Death 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore it was important to test whether “in vivo-activated” granulocytes isolated from inflamed lungs of IT LPS-injected mice might have up-regulated their A2AR expression.
Spec (whether) Regulation (regulated) of Gene_expression (expression) of A2AR in lungs
1) Confidence 0.45 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.22 Pain Relevance 0.14
The expression of neuropeptide tyrosine (NPY) and two of its receptors (Y1- and Y2Rs) in different types of rodent dorsal root ganglion (DRG) and spinal cord neurons, and their regulation by peripheral nerve injury, have suggested a role in neuropathic pain.
Regulation (regulation) of in peripheral nerve Gene_expression (expression) of Y2Rs in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, neuropathic pain, neuropeptide, peripheral nerve injury and spinal cord
2) Confidence 0.00 Published 2007 Journal Peptides Section Abstract Doc Link 17234301 Disease Relevance 0.45 Pain Relevance 0.43

General Comments

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