INT141467

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 4.21
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Glp2r) plasma membrane (Glp2r) signal transducer activity (Glp2r)
Anatomy Link Frequency
nucleus 2
Glp2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 196 100.00 Very High Very High Very High
cytokine 189 100.00 Very High Very High Very High
lidocaine 2 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
isoflurane 14 98.60 Very High Very High Very High
qutenza 10 97.28 Very High Very High Very High
agonist 70 80.08 Quite High
analgesia 7 23.40 Low Low
Buprenorphine 7 20.40 Low Low
metalloproteinase 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 217 100.00 Very High Very High Very High
Hypoxia 266 99.70 Very High Very High Very High
Stress 21 95.76 Very High Very High Very High
Frailty 3 87.40 High High
Anastomotic Leak 28 76.60 Quite High
Injury 98 75.76 Quite High
Wound Healing 77 58.72 Quite High
Multiple System Atrophy 7 48.04 Quite Low
Exsanguination 7 46.88 Quite Low
Body Weight 7 43.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study shows for the first time that the GLP-2R is expressed by vagal afferents, and ip GLP-2 activates the vagal afferent pathway.
Gene_expression (expressed) of GLP-2R
1) Confidence 0.77 Published 2007 Journal Endocrinology Section Abstract Doc Link 17234710 Disease Relevance 0.09 Pain Relevance 0.17
Our aims were to determine whether 1) the GLP-2 receptor (GLP-2R) is expressed on vagal afferents by localizing it to the nodose ganglia; 2) exogenous GLP-2 stimulates the vagal afferent pathway by determining immunoreactivity for c-fos protein in the nucleus of the solitary tract (NTS); and 3) functional ablation of vagal afferents attenuates GLP-2-mediated intestinal growth in rats maintained with total parenteral nutrition (TPN).
Gene_expression (expressed) of GLP-2 in nucleus
2) Confidence 0.77 Published 2007 Journal Endocrinology Section Abstract Doc Link 17234710 Disease Relevance 0 Pain Relevance 0
Our aims were to determine whether 1) the GLP-2 receptor (GLP-2R) is expressed on vagal afferents by localizing it to the nodose ganglia; 2) exogenous GLP-2 stimulates the vagal afferent pathway by determining immunoreactivity for c-fos protein in the nucleus of the solitary tract (NTS); and 3) functional ablation of vagal afferents attenuates GLP-2-mediated intestinal growth in rats maintained with total parenteral nutrition (TPN).
Gene_expression (expressed) of GLP-2R in nucleus
3) Confidence 0.77 Published 2007 Journal Endocrinology Section Abstract Doc Link 17234710 Disease Relevance 0 Pain Relevance 0
GLP-2 Serum Levels
 Mean serum levels of GLP-2 were 35.0 ± 3.1 in control animals (similar in both normoxic and hypoxic), 119 ± 32 in GLP-2-treated animals, and 49.1 ± 10.3?
Gene_expression (levels) of GLP-2 associated with hypoxia
4) Confidence 0.75 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.70 Pain Relevance 0.07
The serum levels of GLP-2 were significantly higher in animals receiving GLP-2 (1-33) (P < .05); however, the levels in GLP-2-MMB-treated animals were not significantly elevated compared to controls.
Gene_expression (levels) of GLP-2
5) Confidence 0.65 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.67 Pain Relevance 0.15
In summary, we have shown that GLP-2 alters the cytokine profile through both the inflammatory and anti-inflammatory cascade and collagen gene expression in both normoxic and hypoxic anastomoses.
Gene_expression (expression) of GLP-2 associated with inflammation, hypoxia and cytokine
6) Confidence 0.65 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.30 Pain Relevance 0.22
One hour post saline/GLP-2/MMB and BrdU injection, they were anesthetized with 1-2% isoflurane and weighed, and a laparotomy was performed.
Gene_expression (injection) of GLP-2 associated with isoflurane
7) Confidence 0.65 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.27 Pain Relevance 0.05
Some animals were pretreated with indomethacin (5 mg/kg, ip), L-NAME (9, 18, 36 and 72 micromol/kg, iv), atropine sulfate (1-2 mg/kg, iv), CCK-1 and CCK-2 receptor antagonists (L-364,718 and L-365,260, 1 mg/kg, iv), exendin (9-39) amide (35 nmol/kg, iv) and lidocaine (74 micromol/kg, iv) prior to the infusion of GLP-2 (4.6 nmol/kg).
Gene_expression (pretreated) of GLP-2 associated with antagonist and lidocaine
8) Confidence 0.65 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17346812 Disease Relevance 0 Pain Relevance 0.31
GLP-2 Serum Levels
 Mean serum levels of GLP-2 were 35.0 ± 3.1 in control animals (similar in both normoxic and hypoxic), 119 ± 32 in GLP-2-treated animals, and 49.1 ± 10.3?
Gene_expression (levels) of GLP-2 associated with hypoxia
9) Confidence 0.58 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.64 Pain Relevance 0.07
GLP-2 Serum Levels
 Mean serum levels of GLP-2 were 35.0 ± 3.1 in control animals (similar in both normoxic and hypoxic), 119 ± 32 in GLP-2-treated animals, and 49.1 ± 10.3?
Gene_expression (animals) of GLP-2-treated associated with hypoxia
10) Confidence 0.57 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.69 Pain Relevance 0.13
In aggregate, these findings would suggest a slight increase in collagen I synthesis with either GLP-2 ligand and, interestingly, a distinct increase in TIMP activity with the long-acting GLP-2 MMB under the stress of hypoxia.
Gene_expression (synthesis) of GLP-2 associated with stress and hypoxia
11) Confidence 0.51 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.87 Pain Relevance 0.07

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