INT141475

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.94
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
lung 2
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 16 100.00 Very High Very High Very High
Inflammatory response 1 98.40 Very High Very High Very High
headache 2 92.96 High High
cva 2 86.64 High High
ischemia 2 82.36 Quite High
fibrosis 2 76.04 Quite High
Spinal cord 1 75.00 Quite High
Chronic pancreatitis 1 25.00 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 7 99.84 Very High Very High Very High
Brain Tumor 1 99.00 Very High Very High Very High
Carcinoma 2 98.80 Very High Very High Very High
INFLAMMATION 4 98.40 Very High Very High Very High
Apoptosis 17 97.98 Very High Very High Very High
Stress 2 97.76 Very High Very High Very High
Cancer 123 96.44 Very High Very High Very High
Pressure And Volume Under Development 2 96.12 Very High Very High Very High
Prostate Cancer 106 95.52 Very High Very High Very High
Headache 2 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies of these genes, including markers of toxic stress, apoptosis, growth regulation and repair, were consistent with documented toxicologic responses to CCl4, where expression of components of cytochrome P450 and other metabolic enzymes (Cyp2C, Cyp3A18, Cyp3A9, SCS and Fmo1) were found to decrease, whereas certain genes involved in the inflammatory response and signal transduction were increased (CD44 and Lgals3) [7].
Negative_regulation (decrease) of Gene_expression (expression) of SCS associated with stress, inflammatory response and apoptosis
1) Confidence 0.41 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.42 Pain Relevance 0.05
The authors found that SCS can produce either an increase of CBF or a reduction or no effect.
Negative_regulation (reduction) of Neg (no) Gene_expression (produce) of SCS associated with spinal-cord stimulation
2) Confidence 0.41 Published 2008 Journal J Neurosurg Sci Section Abstract Doc Link 18500217 Disease Relevance 0.60 Pain Relevance 0.50
Despite evidence that Twist, a highly conserved basic helix-loop-helix transcription factor, is a novel oncogene, there are no reports describing Twist expression in pancreatic cancer.
Negative_regulation (describing) of Gene_expression (expression) of Twist associated with pancreatic cancer
3) Confidence 0.36 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 1.02 Pain Relevance 0
Yang et al. showed that suppression of TWIST1 expression in highly metastatic mammary carcinoma cells specifically inhibited their ability to metastasise to the lung, while ectopic expression resulted in activation of mesenchymal markers and induction of cell motility [62].
Negative_regulation (suppression) of Gene_expression (expression) of TWIST1 in lung associated with carcinoma
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.76 Pain Relevance 0
The fact that TWIST1 and DKK3 expression was deregulated in both hormone-refractory and hormone-naïve patient samples, suggests that these alterations occur earlier in PCa progression and do not act alone in inducing therapy-resistant growth.
Negative_regulation (deregulated) of Gene_expression (expression) of TWIST1 associated with prostate cancer
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.96 Pain Relevance 0.04
Our group found that SCS can produce either an increase of CBF or a reduction or no effect.
Negative_regulation (reduction) of Neg (no) Gene_expression (produce) of SCS associated with spinal-cord stimulation
6) Confidence 0.35 Published 2006 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 17370775 Disease Relevance 0.17 Pain Relevance 0.38

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