INT141476

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.57
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
epithelial cells 2
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 76.04 Quite High
Chronic pancreatitis 1 25.00 Low Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 7 99.84 Very High Very High Very High
Cancer 71 97.44 Very High Very High Very High
Prostate Cancer 53 95.52 Very High Very High Very High
Pancreatitis 5 85.96 High High
Stomach Cancer 1 76.68 Quite High
Pulmonary Fibrosis 1 76.04 Quite High
Hyperplasia 2 74.32 Quite High
Apoptosis 8 66.16 Quite High
Metastasis 18 60.64 Quite High
Disease 15 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that TWIST1 and DKK3 expression was deregulated in both hormone-refractory and hormone-naïve patient samples, suggests that these alterations occur earlier in PCa progression and do not act alone in inducing therapy-resistant growth.
Regulation (deregulated) of Gene_expression (expression) of TWIST1 associated with prostate cancer
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.96 Pain Relevance 0.04
To clarify involvement of Twist expression in pancreatic cancer, we used quantitative reverse transcription-polymerase chain reaction and examined Twist expression in pancreatic cancer, IPMN, and non-neoplastic pancreas using bulk tissues (11 cancers, 18 IPMNs, and 15 non-neoplastic pancreata), microdissected cells (cancer from 22 sections, IPMN from 19 sections, PanIN from 6 sections, and pancreatitis-affected epithelial cells from 14 sections), and pancreatic juice (16 from cancer, 28 from IPMN, and 17 from pancreatitis).
Regulation (involvement) of Gene_expression (expression) of Twist in epithelial cells associated with cancer, pancreatitis and pancreatic cancer
2) Confidence 0.27 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 1.61 Pain Relevance 0

General Comments

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