INT141488

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GSK3B) carbohydrate metabolic process (GSK3B) cytoplasm (GSK3B)
cytosol (GSK3B) nucleolus (GSK3B) nucleus (GSK3B)
GSK3B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 78.88 Quite High
cytokine 21 25.00 Low Low
Inflammation 34 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 62 99.64 Very High Very High Very High
Death 4 99.28 Very High Very High Very High
Cancer 3 88.68 High High
INFLAMMATION 47 78.68 Quite High
Adhesions 2 75.08 Quite High
Breast Cancer 4 75.00 Quite High
Neurodegenerative Disease 10 67.60 Quite High
Lyme Disease 13 50.00 Quite Low
Neuroblastoma 5 5.00 Very Low Very Low Very Low
Lyme Neuroborreliosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prodigiosin-induced apoptosis was recovered by inhibiting GSK-3beta, which might be due, at least in part, to the blockade of the GSK-3beta-dependent up-regulation of death receptors 4 and 5 expression.
Negative_regulation (inhibiting) of GSK-3beta associated with apoptosis and death
1) Confidence 0.24 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.65 Pain Relevance 0.08
Prodigiosin-induced apoptosis was recovered by inhibiting GSK-3beta, which might be due, at least in part, to the blockade of the GSK-3beta-dependent up-regulation of death receptors 4 and 5 expression.
Negative_regulation (blockade) of GSK-3beta-dependent associated with apoptosis and death
2) Confidence 0.18 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.64 Pain Relevance 0.08
Additionally, the transcript for cyclin-dependent kinase 2 (CDK2), which typically drives the cell cycle, was down-regulated, and the G1/S cell cycle checkpoint inhibitors, cyclin-dependent kinase inhibitor 1A (p21) and glycogen synthase kinase 3 beta (GSK3?)
Negative_regulation (inhibitors) of glycogen synthase kinase 3 beta
3) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.29 Pain Relevance 0

General Comments

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