INT14149

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 9.04
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)
Anatomy Link Frequency
plasma 1
thyroid 1
B-cells 1
nodes 1
bladder 1
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Demyelination 1 99.16 Very High Very High Very High
Inflammation 11 98.32 Very High Very High Very High
Pain 9 98.00 Very High Very High Very High
cytokine 4 95.60 Very High Very High Very High
corticosteroid 32 94.88 High High
Neuritis 1 93.76 High High
Osteoarthritis 2 92.96 High High
interstitial cystitis 2 92.96 High High
Rsd 6 92.88 High High
ischemia 2 89.00 High High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 2 100.00 Very High Very High Very High
Pyoderma Gangrenosum 6 99.98 Very High Very High Very High
Demyelinating Disease 1 99.16 Very High Very High Very High
Lymphatic System Cancer 25 99.12 Very High Very High Very High
Disease 86 98.32 Very High Very High Very High
INFLAMMATION 9 98.32 Very High Very High Very High
Pain 5 98.00 Very High Very High Very High
Cancer 20 97.84 Very High Very High Very High
Corneal Disease 4 97.44 Very High Very High Very High
Recurrence 110 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore determined whether immunoglobulin fractions from 14 IC patient and 19 control urine specimens bound in vitro to primary cultures of human bladder epithelial cells, as well as epithelial cells from a variety of other tissues.
immunoglobulin Binding (bound) of in bladder
1) Confidence 0.48 Published 1997 Journal J. Urol. Section Abstract Doc Link 9072548 Disease Relevance 0.51 Pain Relevance 0.17
The patient had a 13-year history of PG associated with monoclonal immunoglobulin-A gammopathy.
immunoglobulin Binding (associated) of associated with pyoderma gangrenosum
2) Confidence 0.32 Published 2007 Journal J Cataract Refract Surg Section Abstract Doc Link 17964412 Disease Relevance 1.08 Pain Relevance 0.10
His Mantoux, immunoglobulin M, and immunoglobulin G for tuberculosis tests were all negative.
immunoglobulin Binding (negative) of associated with mycobacterial infection
3) Confidence 0.17 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2916915 Disease Relevance 0.74 Pain Relevance 0
Aspartame binding in this immunoglobulin fragment is remarkable.
immunoglobulin Binding (binding) of
4) Confidence 0.13 Published 1998 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9630831 Disease Relevance 0.27 Pain Relevance 0.26
Histological findings were consistent with it being a diffuse large cell type lymphoma and Southern blot analysis revealed clonal rearrangement of the immunoglobulin heavy-chain JH.
immunoglobulin Binding (rearrangement) of associated with lymphatic system cancer
5) Confidence 0.11 Published 2004 Journal Respirology Section Abstract Doc Link 14982617 Disease Relevance 1.15 Pain Relevance 0.09
Scintigraphy using radiolabelled human polyclonal non-specific immunoglobulin (HIG) has been recognized as a useful tool for the localization of inflammatory disorders.
immunoglobulin Binding (recognized) of associated with inflammation
6) Confidence 0.10 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16025330 Disease Relevance 0.83 Pain Relevance 0.58
A 56-year-old man presented with clinical and biochemical hyperthyroidism with high thyroid 99mTc uptake, positive result for antimicrosomal antibody (MCHA; 1:8,100) and markedly high activities of thyrotropin-binding inhibitory immunoglobulin (TBII; 90.0%) and thyroid-stimulating antibody (TSAb; 2,400%).
immunoglobulin Binding (binding) of in thyroid associated with hyperthyroidism
7) Confidence 0.05 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1687041 Disease Relevance 0.74 Pain Relevance 0.14
Staining for human immunoglobulin in cryostat sections showed the presence of injected anti-GM1 antibody bound to nodes of Ranvier up to 6 days following intraneural transfer.
immunoglobulin Binding (bound) of in nodes
8) Confidence 0.04 Published 1995 Journal Muscle Nerve Section Abstract Doc Link 7715623 Disease Relevance 0.35 Pain Relevance 0.14
Rapid, temporary improvement may be achieved for myasthenic crises and exacerbations with plasma exchange (PEX) or intravenous immunoglobulin (IVIg).
immunoglobulin Binding (exacerbations) of in plasma
9) Confidence 0.02 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2211463 Disease Relevance 1.01 Pain Relevance 0.18
The risk of recurrence mainly affects patients with primary idiopathic FSGS involving T-cell dysfunction and a putative circulating factor which may be bound to immunoglobulin.
immunoglobulin Binding (bound) of in T-cell associated with recurrence
10) Confidence 0.00 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 1.47 Pain Relevance 0.05
Its known mechanisms of action differ from the anti-CD20 monoclonal antibody which depletes very efficiently CD20+ B-cells, rituximab, by CD22 phosphorylation (Carnahan et al 2003) and by affecting BCR (via immobilized immunoglobulin crosslinking), as well as inducing moderate, but significant, ADCC, without showing direct apoptotic or complement-mediated killing (Carnahan et al 2003).
immunoglobulin Binding (crosslinking) of in B-cells associated with apoptosis
11) Confidence 0.00 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.90 Pain Relevance 0

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