INT141493

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHUK) nucleolus (CHUK) nucleus (CHUK)
cytoplasm (CHUK)
Anatomy Link Frequency
endothelial cells 1
CHUK (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 99.20 Very High Very High Very High
Inflammatory response 3 78.40 Quite High
cINOD 1 35.68 Quite Low
cytokine 1 32.56 Quite Low
Arthritis 14 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 99.20 Very High Very High Very High
Arthritis 27 92.44 High High
Stress 3 75.00 Quite High
Adhesions 1 75.00 Quite High
Protozoal Infection 2 5.00 Very Low Very Low Very Low
Giardiasis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is the first report that describes a stressful situation in the endothelial cells created by excess of antioxidative and anti-inflammatory agents NAC and mito-Q, resulting in the generation of reactive oxygen species, carbonylation and glutathionylation of cellular proteins, inhibition of IKKalpha activity, and up-regulation of ICAM-1expression.
Negative_regulation (inhibition) of IKKalpha in endothelial cells associated with inflammation
1) Confidence 0.07 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.40 Pain Relevance 0.12
They are inhibitors of the nuclear transcription factor NFkappaB.
Negative_regulation (inhibitors) of nuclear transcription factor NFkappaB
2) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1440857 Disease Relevance 0.75 Pain Relevance 0.26

General Comments

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