INT141498

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.47
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pancreas 2
Skeletal muscle 2
stem cell 2
MIR133B (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 52 98.38 Very High Very High Very High
Chronic pancreatitis 2 91.48 High High
lidocaine 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
local anesthetic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 316 99.84 Very High Very High Very High
Impaired Glucose Tolerance 52 98.38 Very High Very High Very High
Adenocarcinoma 9 92.84 High High
Pancreatitis 2 91.48 High High
Insulin Resistance 140 89.36 High High
Neoplastic Processes 1 75.00 Quite High
Disease 68 46.08 Quite Low
Hypertrophy 4 10.00 Low Low
Obesity 28 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of miR-216 and -217 and lack of expression of miR-133a were identified as characteristic of pancreas tissue.
Negative_regulation (lack) of Gene_expression (expression) of miR-133a in pancreas
1) Confidence 0.35 Published 2007 Journal Oncogene Section Abstract Doc Link 17237814 Disease Relevance 0.79 Pain Relevance 0.16
A clear stepwise reduction in mature miR-133a expression was observed across the three clinical groups.
Negative_regulation (reduction) of Gene_expression (expression) of miR-133a
2) Confidence 0.21 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.43 Pain Relevance 0.08
Skeletal muscle miR-133a expression was reduced by five-fold in T2D (P < 0.001).
Negative_regulation (reduced) of Gene_expression (expression) of miR-133a in Skeletal muscle associated with diabetes mellitus
3) Confidence 0.18 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.44 Pain Relevance 0.08
Regulation of miRNA production, post-transcriptionally, is proving to be potentially important for determining stem cell differentiation [93,94] while the protein or signaling factors that inhibit miR-133a production in T2D remain to be determined, this process clearly has the potential to alter muscle differentiation [28].


Negative_regulation (inhibit) of Gene_expression (production) of miR-133a in stem cell associated with diabetes mellitus
4) Confidence 0.15 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.51 Pain Relevance 0
We found that expression of miR-133a was associated with fasting glucose and 2 hour glucose tolerance data (R2 = 0.37, P < 0.001), with higher fasting glucose levels associated with lower miR-133a expression (Figure 2d).
Negative_regulation (lower) of Gene_expression (expression) of miR-133a associated with tolerance and impaired glucose tolerance
5) Confidence 0.13 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.30 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox