INT14151

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2011
Negated 11
Speculated 15
Reported most in Abstract
Documents 311
Total Number 330
Disease Relevance 140.26
Pain Relevance 120.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
leukocytes 7
ventral 5
neurons 5
gastric antrum 4
brain 4
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 620 100.00 Very High Very High Very High
cocaine 219 100.00 Very High Very High Very High
Nicotine 100 100.00 Very High Very High Very High
nMDA receptor antagonist 39 100.00 Very High Very High Very High
calcitonin gene related peptide 24 100.00 Very High Very High Very High
Ventral tegmentum 607 99.98 Very High Very High Very High
tramadol 27 99.96 Very High Very High Very High
opiate 26 99.96 Very High Very High Very High
Glutamate 4127 99.92 Very High Very High Very High
Nucleus accumbens 560 99.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 5203 100.00 Very High Very High Very High
Death 3001 100.00 Very High Very High Very High
Cancer 310 100.00 Very High Very High Very High
Necrosis 220 100.00 Very High Very High Very High
Nervous System Injury 213 100.00 Very High Very High Very High
Adhesions 97 100.00 Very High Very High Very High
Injury 907 99.88 Very High Very High Very High
Stroke 285 99.88 Very High Very High Very High
Cv Unclassified Under Development 596 99.82 Very High Very High Very High
Depression 524 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Negative regulation of caspase-3 expression in the neonatal cerebral cortex by alpha2A-adrenoceptors.
Gene_expression (expression) of caspase-3 in cerebral cortex associated with cerebral cortex
1) Confidence 0.78 Published 2007 Journal Bull. Exp. Biol. Med. Section Title Doc Link 18225740 Disease Relevance 0.09 Pain Relevance 0.18
There was a significant increase in c-Fos, caspase-3 and IL-1beta expression in model groups compared to the control groups at 3 mo and 5 mo after operation.
Gene_expression (expression) of caspase-3
2) Confidence 0.78 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17552004 Disease Relevance 0.15 Pain Relevance 0
Western blot analysis showed time-dependent changes of caspase-3 and IL-1beta protein in the cervical cord and gastric antrum of rats with cervical spondylosis; there was no significant expression of caspase-3 and IL-1beta protein in the control group at 3 mo and 5 mo after the sham operation, whereas there was a significant difference in caspase-3 and IL-1beta protein levels between the model group rats followed up for 3 mo and those for 5 mo (P < 0.05).
Neg (no) Gene_expression (expression) of caspase-3 in gastric antrum
3) Confidence 0.78 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17552004 Disease Relevance 0 Pain Relevance 0
AIM: To determine the expression of c-Fos, caspase-3 and interleukin-1beta (IL-1beta) in the cervical cord and stomach of rats with cervical spondylosis, to analyze their relationship, and to offer an explanation of one possible cause for functional dyspepsia (FD) and irritable bowel syndrome (IBS) caused by cervical spondylosis.
Spec (determine) Gene_expression (expression) of caspase-3 in stomach associated with spondylosis, spastic colon and nud
4) Confidence 0.78 Published 2007 Journal World J. Gastroenterol. Section Abstract Doc Link 17552004 Disease Relevance 0.45 Pain Relevance 0.14
CONCLUSION: There is a significant association of c-Fos, caspase-3 and IL-1beta expressions in the gastric antrum with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis.


Gene_expression (expressions) of caspase-3 in gastric antrum
5) Confidence 0.78 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17552004 Disease Relevance 0 Pain Relevance 0
The expressions of c-Fos, caspase-3 and IL-1beta in the cervical cord and gastric antrum were determined by immunohistochemistry and/or Western blot.
Spec (determined) Gene_expression (expressions) of caspase-3 in gastric antrum
6) Confidence 0.78 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17552004 Disease Relevance 0.18 Pain Relevance 0
To examine the effect of aripiprazole on the expression of morphine-induced CPP, rats received aripiprazole (0, 0.03, 0.1,and 0.3 mg/kg, i.p.) 30 min before testing for the expression of CPP.
Gene_expression (expression) of CPP associated with morphine
7) Confidence 0.78 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.17 Pain Relevance 0.88
After conditioning, CPP expression and locomotion were determined simultaneously in the presence and absence of the respective reward (i.e. food or drug), or after application of 50 mg/kg MPEP (the dose that was most effective in reducing morphine CPP expression in our previous study).
Gene_expression (expression) of CPP associated with morphine
8) Confidence 0.78 Published 2005 Journal Addict Biol Section Abstract Doc Link 16109585 Disease Relevance 0 Pain Relevance 0.30
The results suggest that naloxone may enhance morphine-induced CPP by decreasing locomotor activity that may otherwise compete with expression of CPP.
Gene_expression (expression) of CPP associated with eae, narcan and morphine
9) Confidence 0.78 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2305008 Disease Relevance 0 Pain Relevance 1.12
Although CPP is expressed as increased time spent in a previously rewarded location, the behavioral strategy underlying this change is unknown.
Gene_expression (expressed) of CPP
10) Confidence 0.78 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17093129 Disease Relevance 0 Pain Relevance 0.13
In the present study, the suitability of a schedule allowing repeated testing of CPP expression was evaluated.
Gene_expression (expression) of CPP
11) Confidence 0.78 Published 2005 Journal Amino Acids Section Abstract Doc Link 15791393 Disease Relevance 0 Pain Relevance 0.35
In conclusion, it is suggested as a useful method to study effects of anti-craving-drugs on CPP expression, thereby reducing the overall number of experimental animals.
Gene_expression (expression) of CPP
12) Confidence 0.78 Published 2005 Journal Amino Acids Section Abstract Doc Link 15791393 Disease Relevance 0 Pain Relevance 0.60
Methodologically, the repeated-testing-schedule produced stable CPP expression in both groups over 12 subsequent tests.
Gene_expression (expression) of CPP
13) Confidence 0.78 Published 2005 Journal Amino Acids Section Abstract Doc Link 15791393 Disease Relevance 0 Pain Relevance 0.58
However, microinjection of beta-funaltrexamine into the medial thalamus after morphine conditioning trials, but 23 h prior to a test session, had no effect on the expression of CPP.
Gene_expression (expression) of CPP in medial associated with thalamus and morphine
14) Confidence 0.76 Published 2008 Journal Neuroscience Section Abstract Doc Link 18222040 Disease Relevance 0 Pain Relevance 1.13
In littermate wild-type rats, the injured centrilobular hepatocytes were positive for TUNEL staining and featured elevated expre ssion of cleaved caspase-3 and Cx43, which is not expressed in normal hepatocytes.
Neg (not) Gene_expression (expressed) of caspase-3 in hepatocytes
15) Confidence 0.75 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.75 Pain Relevance 0.53
Anti-apoptotic mechanisms induced by PC are several: induction of Bcl-2, reductions in caspase-3 synthesis and p-53 activation, and reductions in mitochondrial cytochrome c [9,185].


Gene_expression (synthesis) of caspase-3 associated with apoptosis
16) Confidence 0.75 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.80 Pain Relevance 0.54
Double label immunohistochemistry revealed co-expression of caspase-9 and DNA fragmentation or caspase-3 and DNA fragmentation.
Gene_expression (co-expression) of caspase-3
17) Confidence 0.75 Published 2005 Journal Brain Res. Section Abstract Doc Link 16125681 Disease Relevance 0.78 Pain Relevance 0.61
Caspase-3 and aquaporin-4 protein expression and caspase-3 activity were analyzed.
Spec (analyzed) Gene_expression (expression) of Caspase-3
18) Confidence 0.74 Published 2010 Journal Anesthesiology Section Body Doc Link 20098129 Disease Relevance 0.22 Pain Relevance 0
Caspase-3 and aquaporin-4 protein expression and caspase-3 activity were analyzed.
Spec (analyzed) Gene_expression (expression) of caspase-3
19) Confidence 0.74 Published 2010 Journal Anesthesiology Section Body Doc Link 20098129 Disease Relevance 0.22 Pain Relevance 0
ALCAR reduces cytosolic cytochrome C and caspase 3 active fragments expression in a significant manner with respect to saline treatment.
Gene_expression (expression) of caspase 3
20) Confidence 0.74 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17714181 Disease Relevance 1.44 Pain Relevance 0.55

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