INT14152

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Context Info
Confidence 0.61
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 46
Total Number 48
Disease Relevance 20.01
Pain Relevance 15.90

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transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
liver 11
blood 4
plasma 3
kidney 3
hepatocyte 1
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 407 100.00 Very High Very High Very High
ischemia 76 97.92 Very High Very High Very High
isoflurane 10 97.60 Very High Very High Very High
Glutamate 5 96.88 Very High Very High Very High
Inflammation 163 96.66 Very High Very High Very High
anesthesia 22 95.76 Very High Very High Very High
ketamine 4 95.40 Very High Very High Very High
aspirin 6 92.32 High High
Analgesic 20 91.16 High High
Kinase C 52 89.24 High High
Disease Link Frequency Relevance Heat
Cancer 145 100.00 Very High Very High Very High
Necrosis 71 100.00 Very High Very High Very High
Hepatotoxicity 200 99.52 Very High Very High Very High
Body Weight 115 98.44 Very High Very High Very High
Disorder Of Lipid Metabolism 8 98.00 Very High Very High Very High
Toxicity 306 97.92 Very High Very High Very High
Cv Unclassified Under Development 87 97.92 Very High Very High Very High
Injury 231 97.44 Very High Very High Very High
Overdose 10 97.20 Very High Very High Very High
Stress 69 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant elevation (p<0.001) of the levels of AST and ALT was observed in mice toxicated with APAP.
Gene_expression (levels) of AST associated with paracetamol
1) Confidence 0.61 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.68 Pain Relevance 0.69
The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05).
Gene_expression (levels) of AST
2) Confidence 0.56 Published 2006 Journal Phytother Res Section Abstract Doc Link 16619345 Disease Relevance 0.17 Pain Relevance 0.65
They were sacrificed after 6 hr and 24 hr for assessment of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total RNA isolation, cDNA microarray analysis and histopathological analysis of liver injury.
Gene_expression (assessment) of AST in liver associated with injury
3) Confidence 0.51 Published 2006 Journal Physiol Chem Phys Med NMR Section Abstract Doc Link 18472468 Disease Relevance 0.36 Pain Relevance 0.76
On the other hand, APAP induced increases in plasma AST and ALT levels in the highest dose group only, and the DNA damage in the liver increased at the same dose.
Gene_expression (levels) of AST in plasma associated with paracetamol
4) Confidence 0.49 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.09 Pain Relevance 0.38
Eight hours after the APAP injection, the levels of serum aminotransferase (AST) and alanine aminotransferase (ALT) were measured and liver, kidney and lung tissue were examined for morphological changes.
Gene_expression (levels) of AST in lung associated with paracetamol
5) Confidence 0.48 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.65 Pain Relevance 0.63
Three and six hours after intraperitoneal injection of TBE, intramuscular injection of ketamine/xylazine combination (K/X), intraperitoneal injection of pentobarbital (PB), and inhalation of isoflurane (IF), or intraperitoneal and intramuscular injection of control saline, mice were exsanguinated and serum was obtained for measurement of hepatic aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glutamyltransferase (GGT).
Gene_expression (measurement) of AST associated with ketamine and isoflurane
6) Confidence 0.46 Published 2002 Journal Comp. Med. Section Abstract Doc Link 11900415 Disease Relevance 0.17 Pain Relevance 0.30
With regard to hematology and blood chemistry results, nephrotoxic markers were not changed, but aspartate aminotransferase (AST) and alanine aminotransferase (ALT) increased in the 150 mg/kg-treated group, and bone marrow counts (BMC) decreased in all of the treatment groups 24 hr after treatment.
Gene_expression (increased) of AST in blood
7) Confidence 0.42 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.08 Pain Relevance 0.41
However, no additional reduction in plasma levels of AST and ALT was observed when sodium sulphate was co-administered with NAC.
Gene_expression (levels) of AST in plasma
8) Confidence 0.38 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.15 Pain Relevance 0.72
However, at higher doses of sunitinib in group D, both the AST and ALT levels were significantly increased (Figure 1).
Gene_expression (levels) of AST
9) Confidence 0.38 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.42 Pain Relevance 0.47
Blood urea nitrogen (BUN), serum creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels in blood, and glutathione (GSH), malondialdehyde (MDA), oxidized protein levels and myeloperoxidase (MPO) activity in liver and kidney tissues were measured.
Gene_expression (levels) of AST in kidney associated with urological neuroanatomy
10) Confidence 0.38 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.39 Pain Relevance 0.61
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Gene_expression (depletion) of AST associated with paracetamol and hepatotoxicity
11) Confidence 0.36 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98
Mice were sacrificed 12 h after the APAP injection to determine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation, and caspase-3 expression in liver tissues.
Gene_expression (levels) of AST in liver associated with necrosis, paracetamol and cancer
12) Confidence 0.36 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.65 Pain Relevance 0.84
Prior to AAP treatment, the mice pretreated with FSSC showed significantly reduced levels of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) activity.
Gene_expression (levels) of AST associated with paracetamol
13) Confidence 0.35 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 18838823 Disease Relevance 0.31 Pain Relevance 0.64
In contrast, after sunitinib was administered at escalating doses, the serum AST and ALT levels were only slightly elevated and mild liver damage with slight vascular congestion and signs of hepatocyte regeneration were found (Figure 3).
Gene_expression (levels) of serum AST in hepatocyte associated with hepatotoxicity
14) Confidence 0.33 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.55 Pain Relevance 0.50
A synthetic method suitable for the preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62), was established; i.e., SD-62 was synthesized by a 5 min treatment of the active ester precursor with ammonia.
Gene_expression (synthesized) of SD-62
15) Confidence 0.32 Published 1991 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1687212 Disease Relevance 0 Pain Relevance 0.08
Blood urea nitrogen, serum creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in blood and glutathione (GSH) and malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity and collagen contents in liver and kidney tissues were measured.
Gene_expression (levels) of AST in kidney associated with urological neuroanatomy
16) Confidence 0.31 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.24 Pain Relevance 0.72
Set IV A results (Table 10) clearly depict an increase in serum AST and ALT levels indicating hepatotoxicity to a mild extent.
Gene_expression (levels) of AST associated with hepatotoxicity
17) Confidence 0.29 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2661047 Disease Relevance 0.44 Pain Relevance 0
The biochemical parameters like ALT and AST levels are also within normal limits which rule out hepatotoxicity.
Gene_expression (levels) of AST associated with hepatotoxicity
18) Confidence 0.29 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2661047 Disease Relevance 0.32 Pain Relevance 0
Administration of aqueous stem extract (400 mg/kg body weight, orally) and aqueous leaves extract (400 mg/kg body weight, orally) along with the lead nitrate (5 mg/kg body weight, i.p. for 30 days) increased the activities of SOD and CAT and decreased the levels of AST, ALT, ALP, and ACP enzymes in mice.
Gene_expression (levels) of AST in body associated with body weight
19) Confidence 0.28 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964743 Disease Relevance 0.51 Pain Relevance 0
MATERIALS AND METHODS: The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in mouse sera, and glutathione (GSH), malondialdehyde (MDA) in mouse liver tissues were measured.
Gene_expression (levels) of AST in liver
20) Confidence 0.27 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 19833181 Disease Relevance 0.10 Pain Relevance 0

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