INT141528

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.40
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 11 100.00 Very High Very High Very High
cINOD 14 97.94 Very High Very High Very High
agonist 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 97.66 Very High Very High Very High
Adhesions 4 71.56 Quite High
Disease 36 62.08 Quite High
Alzheimer's Dementia 22 56.64 Quite High
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OSBP1 overexpression did not appear to produce changes in APP subcellular localization.
Regulation (changes) of Localization (localization) of APP
1) Confidence 0.52 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.07 Pain Relevance 0
It is of interest that while OSBP1 overexpression produced no obvious changes in the localization of APP, an altered localization of APP-Notch2 dimers was detected.
Neg (no) Regulation (changes) of Localization (localization) of APP
2) Confidence 0.44 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
When OSBP1 was not overexpressed, 25OH had no effect on the localization of the APP-Notch2 dimers, perhaps because basal levels of OSBP1 were not high enough to counteract the effects of 25OH binding to other ORPs or LXRs.
Neg (no) Regulation (effect) of Localization (localization) of APP
3) Confidence 0.44 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.05 Pain Relevance 0
It is of interest that while OSBP1 overexpression produced no obvious changes in the localization of APP, an altered localization of APP-Notch2 dimers was detected.
Regulation (altered) of Localization (localization) of APP
4) Confidence 0.26 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
In addition, the non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen and sulindac sulfide have no effect on the formation and turnover of Abeta(46), but rather modulate the ratio of secreted Abeta at a step after the formation of Abeta(40) and Abeta(42).
Neg (no) Regulation (modulate) of Localization (secreted) of Abeta associated with inflammation, cinod and abeta
5) Confidence 0.08 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241131 Disease Relevance 0.15 Pain Relevance 0.67

General Comments

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