INT141536

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 4.71
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Anatomy Link Frequency
neuronal 2
oligodendrocyte 1
neural 1
Rtn4r (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 49 99.84 Very High Very High Very High
Abeta 10 98.76 Very High Very High Very High
nMDA receptor 14 97.72 Very High Very High Very High
Central nervous system 43 96.00 Very High Very High Very High
Hippocampus 14 91.24 High High
amygdala 14 90.28 High High
antidepressant 7 71.96 Quite High
cINOD 2 62.88 Quite High
depression 28 62.28 Quite High
Catechol-O-methyltransferase 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 434 98.68 Very High Very High Very High
Disease 81 97.16 Very High Very High Very High
Pathologic Processes 7 96.52 Very High Very High Very High
Cognitive Disorder 56 95.88 Very High Very High Very High
Disorder Of Lipid Metabolism 2 91.04 High High
Injury 40 87.96 High High
Targeted Disruption 30 86.80 High High
Alzheimer's Dementia 6 83.40 Quite High
Stress 7 68.36 Quite High
Anxiety Disorder 98 64.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is therefore conceivable that RTN4R deficiency facilitates the effect of other schizophrenia susceptibility genes or disease-related pathological processes by destabilizing relevant neural circuits during development.
Negative_regulation (deficiency) of RTN4R in neural associated with pathologic processes, disease and schizophrenia
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.65 Pain Relevance 0.15
We also provide evidence that Rtn4r deficiency can modulate the long-term behavioral effects of transient postnatal N-methyl-D-aspartate (NMDA) receptor hypofunction.


Negative_regulation (deficiency) of Rtn4r
2) Confidence 0.43 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2077930 Disease Relevance 0.85 Pain Relevance 0.05
In addition, we cannot ignore the possibility that RTN4R deficiency contributes to other phenotypic components not assayed here.
Negative_regulation (deficiency) of RTN4R
3) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.41 Pain Relevance 0
We employed this model to ask whether Rtn4r deficiency modulates the long-term behavioral effects of postnatal NMDA receptor hypofunction.
Spec (whether) Negative_regulation (deficiency) of Rtn4r associated with nmda receptor
4) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.39 Pain Relevance 0.12
Our animal model studies, designed to facilitate interpretation of our human genetic results, indicated an effect of Rtn4r on locomotor activity in an open field assay.
Negative_regulation (effect) of Rtn4r associated with eae
5) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.44 Pain Relevance 0.05
As a result of this rearrangement, the Rtn4r mouse gene is located between the Prodh gene (?
Negative_regulation (located) of Rtn4r
6) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.24 Pain Relevance 0
We used the T-maze delayed alternation task [46], [47] to examine whether deficiency in Rtn4r-mediated signaling activity is associated with changes in spatial working memory.
Spec (whether) Negative_regulation (deficiency) of Rtn4r-mediated
7) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.35 Pain Relevance 0.17
Several myelin inhibitors of axonal growth, including Nogo-66, myelin-associated glycoprotein, and oligodendrocyte-myelin glycoprotein, exert their effects through NgR.
Negative_regulation (inhibitors) of Nogo-66 in oligodendrocyte
8) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.40 Pain Relevance 0
These include the neuronal Munc-18 interacting proteins (Mints)/X11s, members of the reticulon family (RTN-3 and RTN-4/Nogo-B), the Nogo-66 receptor (NgR), the peptidyl-prolyl isomerase Pin1 and the Rho family GTPases and their effectors.
Negative_regulation (include) of Nogo-66 receptor in neuronal
9) Confidence 0.03 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241154 Disease Relevance 0.48 Pain Relevance 0.22
These include the neuronal Munc-18 interacting proteins (Mints)/X11s, members of the reticulon family (RTN-3 and RTN-4/Nogo-B), the Nogo-66 receptor (NgR), the peptidyl-prolyl isomerase Pin1 and the Rho family GTPases and their effectors.
Negative_regulation (include) of NgR in neuronal
10) Confidence 0.03 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241154 Disease Relevance 0.48 Pain Relevance 0.22

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