INT141558

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.41
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Naalad2) cellular_component (Naalad2)
Anatomy Link Frequency
brain 2
paw 1
Naalad2 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 85 99.92 Very High Very High Very High
Pain 99 99.68 Very High Very High Very High
Eae 70 99.04 Very High Very High Very High
antagonist 32 98.76 Very High Very High Very High
Analgesic 63 97.28 Very High Very High Very High
agonist 43 96.80 Very High Very High Very High
Opioid 15 95.12 Very High Very High Very High
Cancer pain 5 94.60 High High
Neuropathic pain 11 93.76 High High
Inflammation 27 93.04 High High
Disease Link Frequency Relevance Heat
Pain 99 99.68 Very High Very High Very High
Inflammatory Pain 61 99.04 Very High Very High Very High
Bone Cancer 10 94.40 High High
Neuropathic Pain 21 93.76 High High
INFLAMMATION 27 93.04 High High
Nociception 15 89.84 High High
Urological Neuroanatomy 10 44.72 Quite Low
Overdose 5 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Akathisia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the conclusion that peripherally administered NAAG peptidase inhibitors increase the activation of mGluR3 by NAAG that is released from peripheral sensory neurites, we found that the tissue average concentration of NAAG in the unstimulated rat hind paw was about 6 microm.
Positive_regulation (increase) of NAAG peptidase in paw
1) Confidence 0.45 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17241276 Disease Relevance 0.51 Pain Relevance 1.04
Relevant to these NAAG peptidase inhibition data, the periaquaductal grey contains a relatively high concentration of both NAAG and NAAG peptidase activity [29].
Positive_regulation (concentration) of NAAG
2) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.29 Pain Relevance 1.05
Relevant to these NAAG peptidase inhibition data, the periaquaductal grey contains a relatively high concentration of both NAAG and NAAG peptidase activity [29].
Positive_regulation (concentration) of NAAG peptidase
3) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.29 Pain Relevance 1.11
Consistent with the conclusion that inhibitors of NAAG peptidases achieve analgesia by elevating the degree of NAAG activation of a group II mGluR, group II antagonists completely reverse these analgesic actions.
Positive_regulation (activation) of NAAG associated with analgesic, antagonist and analgesia
4) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.58 Pain Relevance 1.06
These data contribute to proof of the concept that NAAG peptidase inhibition is a novel therapeutic approach to inflammatory pain and that these inhibitors achieve analgesia by elevating synaptic levels of NAAG within pain processing circuits in brain.



Positive_regulation (elevating) of NAAG in brain associated with pain, eae and analgesia
5) Confidence 0.08 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2517065 Disease Relevance 0.41 Pain Relevance 0.93
This research aimed at determining if analgesia obtained following systemic administration of NAAG peptidase inhibitors is due to NAAG activation of group II mGluRs in brain circuits that mediate perception of inflammatory pain.
Positive_regulation (activation) of NAAG in brain associated with eae and analgesia
6) Confidence 0.08 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2517065 Disease Relevance 0.34 Pain Relevance 0.85

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox