INT141559

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.14
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Naalad2) cellular_component (Naalad2)
Anatomy Link Frequency
neuronal 1
paw 1
Naalad2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 3 99.96 Very High Very High Very High
Glutamate 9 99.92 Very High Very High Very High
Glutamate receptor 16 98.52 Very High Very High Very High
gABA 9 98.44 Very High Very High Very High
agonist 27 93.76 High High
Pain 61 89.72 High High
antagonist 20 84.56 Quite High
analgesia 51 83.84 Quite High
Eae 42 82.08 Quite High
Analgesic 39 79.28 Quite High
Disease Link Frequency Relevance Heat
Pain 61 89.72 High High
Inflammatory Pain 37 82.08 Quite High
INFLAMMATION 17 71.16 Quite High
Neuropathic Pain 13 61.80 Quite High
Bone Cancer 6 60.08 Quite High
Nociception 9 36.64 Quite Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Akathisia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the conclusion that peripherally administered NAAG peptidase inhibitors increase the activation of mGluR3 by NAAG that is released from peripheral sensory neurites, we found that the tissue average concentration of NAAG in the unstimulated rat hind paw was about 6 microm.
Localization (released) of NAAG in paw
1) Confidence 0.55 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17241276 Disease Relevance 0.49 Pain Relevance 1.02
Two enzymes that inactivate synaptically released NAAG, glutamate carboxypeptidase II and III, have been cloned and characterized [11-15].
Localization (released) of NAAG associated with glutamate
2) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.32 Pain Relevance 0.74
Consistent with other neuropeptides, NAAG is released under conditions of high neuronal activity and acts at presynaptic receptors [4-6].
Localization (released) of NAAG in neuronal associated with neuropeptide
3) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.17 Pain Relevance 0.44
Synaptically released NAAG activates the group II metabotropic glutamate receptors [mGluR3 >> mGluR2; [6-8]].
Localization (released) of NAAG associated with glutamate receptor
4) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2517065 Disease Relevance 0.16 Pain Relevance 0.46

General Comments

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