INT141565

Context Info Confidence 0.19 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 2.61 Pain Relevance 0.39

nucleus (Cdt1) cell cycle (Cdt1) DNA binding (Cdt1)

Cdt1 (Mus musculus)

Pain Link Frequency Relevance Heat Antinociceptive 1 93.20 Inflammation 49 92.40 cytokine 53 89.20 Hyperalgesia 1 83.88 fifth nerve 3 50.00 Quantitative sensory testing 32 38.04 cOX1 1 25.00 COX2 1 25.00 Pain 16 21.36 rheumatoid arthritis 88 5.00

Disease Link Frequency Relevance Heat Cancer 5 99.68 Necrosis 5 99.44 Repression 268 98.88 Skin Diseases 2 93.56 INFLAMMATION 50 92.40 Hyperalgesia 1 83.88 Systemic Sclerosis 34 77.52 Limited Scleroderma 1 74.60 Diffuse Scleroderma 1 72.48 Zygomatic Fractures 2 71.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These highly expressed genes included cell cycle genes CENPE, CDC7 and CDT1, FGF5, tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) and TRAF interacting protein (TRIP).

Gene_expression (expressed) of CDT1 associated with necrosis and cancer

1) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.01 Pain Relevance 0.10

When two CaRRE 1 motifs were introduced in the Dup175 exon (Dup175CA10+13), splicing was completely repressed even in the absence of CaMK IV activity (Figure 4A, lanes 11 and 12).

Gene_expression (introduced) of Dup175

2) Confidence 0.16 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.19 Pain Relevance 0

CaRRE 2 was inserted at the +3 position of the Dup175 exon, the same position relative to the 3?

Gene_expression (exon) of Dup175

3) Confidence 0.16 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.20 Pain Relevance 0

This effect was due to the introduced CaRRE 1, because a small point mutation in the element reduced its effect, and replacement with a neutral IgM sequence at the same position in Dup175 exon was not able to confer the repression (Figure 4A, lanes 5–8).

Gene_expression (exon) of Dup175 associated with repression

4) Confidence 0.16 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.36 Pain Relevance 0

In contrast, the E21 exon alone, when fused to the Dup175 exon 3?

Gene_expression (exon) of Dup175

5) Confidence 0.16 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.43 Pain Relevance 0

Significant differences (p < 0.05) between control group and test side 1 week after surgery were shown for CDT (?

Gene_expression (shown) of CDT

6) Confidence 0.03 Published 2010 Journal Head Face Med Section Body Doc Link PMC2984556 Disease Relevance 0.07 Pain Relevance 0

Intraperitoneal injection of BjV but not of CdtV induced the release and PGD(2) at 30 min and of PGE(2) from 3 up to 12 h after injection.

Gene_expression (injection) of CdtV

7) Confidence 0.01 Published 2007 Journal Toxicon Section Abstract Doc Link 17241651 Disease Relevance 0.35 Pain Relevance 0.29

General Comments

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