INT14159

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Context Info
Confidence 0.08
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.06
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
forebrain 2
AGS 2
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 14 100.00 Very High Very High Very High
gABA 4 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
Delta opioid receptors 3 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
nMDA receptor 2 100.00 Very High Very High Very High
Nicotine 9 99.96 Very High Very High Very High
Clonidine 1 99.76 Very High Very High Very High
Periaqueductal grey 8 99.20 Very High Very High Very High
potassium channel 2 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tics 6 99.40 Very High Very High Very High
Urological Neuroanatomy 8 99.20 Very High Very High Very High
Alagille Syndrome 5 98.08 Very High Very High Very High
Convulsion 2 92.88 High High
Anxiety Disorder 1 85.92 High High
Depression 1 84.96 Quite High
Epilepsy 3 84.68 Quite High
Pain 1 81.28 Quite High
Toxicity 1 25.00 Low Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Water and NaCl intake is strongly inhibited by the activation of alpha(2)-adrenergic receptors with clonidine or moxonidine (alpha(2)-adrenergic/imidazoline agonists) injected peripherally or into the forebrain and by serotonin and cholecystokinin in the lateral parabrachial nucleus (LPBN).
Negative_regulation (inhibited) of Positive_regulation (activation) of receptors in forebrain associated with agonist, cholecystokinin, serotonin, parabrachial and clonidine
1) Confidence 0.08 Published 2004 Journal Neuroscience Section Abstract Doc Link 15489025 Disease Relevance 0 Pain Relevance 0.36
In conclusion, the activation of kappa-opioid receptors clearly prevented nicotine-induced locomotor stimulation.
Negative_regulation (prevented) of Positive_regulation (activation) of receptors associated with nicotine and kappa opioid receptor
2) Confidence 0.04 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044755 Disease Relevance 0.08 Pain Relevance 1.12
Selective activation of kappa-opioid receptors by the cyclohexylbenzeneaceamide U69593 (0.02 microM) inhibited (by 40-45%) the release of [3H]dopamine (DA) from striatal slices, whereas selective activation of delta-opioid receptors by [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 (DSTBULET; 0.1 microM) caused an inhibition (by 38-46%) of striatal [14C]acetylcholine (ACh) release.
Negative_regulation (inhibited) of Positive_regulation (activation) of receptors associated with dopamine, kappa opioid receptor and delta opioid receptors
3) Confidence 0.04 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1687463 Disease Relevance 0.17 Pain Relevance 0.74
Selective activation of kappa-opioid receptors by the cyclohexylbenzeneaceamide U69593 (0.02 microM) inhibited (by 40-45%) the release of [3H]dopamine (DA) from striatal slices, whereas selective activation of delta-opioid receptors by [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 (DSTBULET; 0.1 microM) caused an inhibition (by 38-46%) of striatal [14C]acetylcholine (ACh) release.
Negative_regulation (inhibited) of Positive_regulation (activation) of receptors associated with dopamine, kappa opioid receptor and delta opioid receptors
4) Confidence 0.04 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1687463 Disease Relevance 0.16 Pain Relevance 0.80
Activation of mu-receptors by the enkephalin analogue Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol (DAGO) inhibited the (electrically evoked) release of [3H]noradrenaline (NA) from superfused cortical slices and this inhibitory effect was antagonized in a competitive fashion by all of the octapeptides tested (pA2 values: CTOP and CTAP 7.9-8.0, TCTOP and TCTAP 8.7-8.8).
Negative_regulation (inhibited) of Positive_regulation (Activation) of receptors associated with noradrenaline and enkephalin
5) Confidence 0.04 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1687463 Disease Relevance 0.20 Pain Relevance 0.63
Activation of sigma receptors reversibly blocked delayed outwardly rectifying potassium channels, large conductance Ca(2+)-sensitive K(+) channels, and the M-current with maximal inhibition >80%.
Negative_regulation (blocked) of Positive_regulation (Activation) of receptors associated with potassium channel
6) Confidence 0.03 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15764734 Disease Relevance 0 Pain Relevance 0.29
Blockade of NMDA receptors by AP7 (both doses) or activation of GABA(A) receptors with THIP (15 nmol/side) in the PAG suppressed AGS susceptibility.
Negative_regulation (Blockade) of Positive_regulation (activation) of receptors in AGS associated with gaba, alagille syndrome, periaqueductal grey and nmda receptor
7) Confidence 0.03 Published 1999 Journal Epilepsy Res. Section Abstract Doc Link 10232793 Disease Relevance 1.28 Pain Relevance 1.11
This would indicate that the changes in the CNS functions after CVP exposure may be the consequence of increased cholinergic activity due to AChE inhibition rather than to a direct stimulation of cholinergic muscarinic receptors by CVP.
Negative_regulation (inhibition) of Positive_regulation (stimulation) of receptors
8) Confidence 0.00 Published 1997 Journal Int J Occup Med Environ Health Section Abstract Doc Link 9575664 Disease Relevance 0.17 Pain Relevance 0.11

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