INT1416

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Context Info
Confidence 0.72
First Reported 1977
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 10.71
Pain Relevance 15.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
keratinocytes 4
plasma 3
pituitary 3
cartilage 2
brain 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 39 100.00 Very High Very High Very High
melanocortin 1 receptor 26 100.00 Very High Very High Very High
Dynorphin 15 100.00 Very High Very High Very High
opiate 15 100.00 Very High Very High Very High
Calcitonin gene-related peptide 7 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
Kappa opioid receptor 4 100.00 Very High Very High Very High
Neuropeptide 28 99.92 Very High Very High Very High
Morphine 5 99.88 Very High Very High Very High
Opioid 25 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 9 99.72 Very High Very High Very High
Neuroblastoma 9 99.60 Very High Very High Very High
Metastasis 12 99.56 Very High Very High Very High
Blister 2 99.52 Very High Very High Very High
Breast Cancer 32 98.68 Very High Very High Very High
Cystitis 4 97.68 Very High Very High Very High
Pain 7 97.36 Very High Very High Very High
Erythema 1 96.84 Very High Very High Very High
Weight Loss 64 94.68 High High
Myocardial Infarction 4 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results appear to constitute the first demonstration of a POMC-related gene transcribed in an invertebrate.
Transcription (transcribed) of POMC-related gene
1) Confidence 0.72 Published 1990 Journal New Biol. Section Abstract Doc Link 1964086 Disease Relevance 0.08 Pain Relevance 0.16
The mRNA expression of the pro-opiomelanocortin (POMC) gene was detected in tumoral cells by reverse transcriptase polymerase chain reaction (RT-PCR).
Transcription (expression) of pro-opiomelanocortin
2) Confidence 0.71 Published 2004 Journal Breast J Section Abstract Doc Link 15239795 Disease Relevance 1.31 Pain Relevance 0.08
TRX suppressed the UVB-induced production and secretion of alpha-melanocyte stimulating hormone (alpha-MSH) and of adrenocorticotropic hormone (ACTH), and also suppressed proopiomelanocortin (POMC) mRNA expression by normal human keratinocytes; however, TRX upregulated melanocortin 1 receptor (MC1-R) expression synergistically with UVB in normal human keratinocytes.
Transcription (expression) of proopiomelanocortin in keratinocytes associated with melanocortin 1 receptor
3) Confidence 0.69 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.19 Pain Relevance 0.21
TRX suppressed the UVB-induced production and secretion of alpha-melanocyte stimulating hormone (alpha-MSH) and of adrenocorticotropic hormone (ACTH), and also suppressed proopiomelanocortin (POMC) mRNA expression by normal human keratinocytes; however, TRX upregulated melanocortin 1 receptor (MC1-R) expression synergistically with UVB in normal human keratinocytes.
Transcription (expression) of POMC in keratinocytes associated with melanocortin 1 receptor
4) Confidence 0.69 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.19 Pain Relevance 0.21
The mRNA expression of the pro-opiomelanocortin (POMC) gene was detected in tumoral cells by reverse transcriptase polymerase chain reaction (RT-PCR).
Transcription (expression) of POMC
5) Confidence 0.69 Published 2004 Journal Breast J Section Abstract Doc Link 15239795 Disease Relevance 1.31 Pain Relevance 0.08
Detection of mRNA transcripts of truncated opiate precursor (POMC) in human cartilage.
Transcription (Detection) of POMC in cartilage associated with opiate
6) Confidence 0.69 Published 2006 Journal Cell Biochem. Funct. Section Title Doc Link 15898126 Disease Relevance 0.08 Pain Relevance 0.14
Several human neuroblastoma cell lines express transcripts of the proopiomelanocortin (POMC) gene of 0.8 kb and 9.5 kb, thus different from the characteristic pituitary 1.2 kb POMC mRNA.
Transcription (transcripts) of POMC in pituitary associated with neuroblastoma
7) Confidence 0.69 Published 1991 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2068137 Disease Relevance 0.17 Pain Relevance 0.07
While moderate increase of CRH output is important for stimulation of POMC transcription, the increase of the VP:CRH secretion ratio appears to be important in maintaining the secretory capacity of the pituitary corticotroph during chronic stimulation.
Transcription (transcription) of POMC in pituitary
8) Confidence 0.69 Published 1994 Journal Front Neuroendocrinol Section Abstract Doc Link 7895891 Disease Relevance 0.60 Pain Relevance 0.07
The helminth Schistosoma mansoni expresses a peptide similar to human beta-endorphin and possesses a proopiomelanocortin-related gene.
Transcription (possesses) of proopiomelanocortin
9) Confidence 0.69 Published 1990 Journal New Biol. Section Title Doc Link 1964086 Disease Relevance 0.07 Pain Relevance 0.24
Between-group differences were not found for beta-endorphin, pHVA, or pMHPG.
Neg (not) Transcription (found) of beta-endorphin
10) Confidence 0.69 Published 1996 Journal Psychiatry Res Section Abstract Doc Link 8804130 Disease Relevance 0.49 Pain Relevance 0.23
Using HPLC we identified for the first time the presence of ACTH1-39, ACTH1-17, ACTH1-10, acetylated ACTH1-10, alpha-MSH, and desacetyl alpha-MSH in epidermis and in cultured keratinocytes.
Transcription (presence) of alpha-MSH in keratinocytes
11) Confidence 0.68 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9359624 Disease Relevance 0 Pain Relevance 0.15
Using HPLC we identified for the first time the presence of ACTH1-39, ACTH1-17, ACTH1-10, acetylated ACTH1-10, alpha-MSH, and desacetyl alpha-MSH in epidermis and in cultured keratinocytes.
Transcription (presence) of alpha-MSH in keratinocytes
12) Confidence 0.68 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9359624 Disease Relevance 0 Pain Relevance 0.15
The distribution of Met-enkephalin like immunoreactivity in the brain of Apteronotus leptorhynchus, with emphasis on the electrosensory system.
Transcription (distribution) of Met-enkephalin in brain associated with enkephalin
13) Confidence 0.67 Published 1996 Journal J. Chem. Neuroanat. Section Title Doc Link 8906459 Disease Relevance 0 Pain Relevance 0.51
This study has demonstrated that human hair follicle melanocytes (HFM) express mRNA for the mu-opiate receptor and POMC.
Transcription (express) of POMC in hair follicle associated with opiate
14) Confidence 0.67 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15191559 Disease Relevance 0.08 Pain Relevance 0.53
A positive and significant relationship was found between ACTH and cortisol levels.
Transcription (found) of ACTH
15) Confidence 0.65 Published 2009 Journal Breastfeed Med Section Body Doc Link 19731998 Disease Relevance 0 Pain Relevance 0
Expression of pre-opiomelanocortin (POMC) mRNA in undifferentiated and in vitro differentiated human neuroblastoma cell lines.
Transcription (Expression) of pre-opiomelanocortin associated with neuroblastoma
16) Confidence 0.63 Published 1991 Journal Prog. Clin. Biol. Res. Section Title Doc Link 2068137 Disease Relevance 0.19 Pain Relevance 0.08
Several human neuroblastoma cell lines express transcripts of the proopiomelanocortin (POMC) gene of 0.8 kb and 9.5 kb, thus different from the characteristic pituitary 1.2 kb POMC mRNA.
Transcription (transcripts) of proopiomelanocortin in pituitary associated with neuroblastoma
17) Confidence 0.60 Published 1991 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2068137 Disease Relevance 0.17 Pain Relevance 0.07
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Transcription (transcription) of alpha-MSH associated with melanocortin 1 receptor
18) Confidence 0.54 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.34 Pain Relevance 0.87
Beta-endorphin plasma levels were determined after melatonin administration (0.2 mg/kg b.w. i.m. at 2 p.m.).
Transcription (levels) of Beta-endorphin in plasma
19) Confidence 0.53 Published 1986 Journal J. Neural Transm. Section Abstract Doc Link 2937880 Disease Relevance 0 Pain Relevance 0.32
The morphine-like activity of beta-endorphin is comparable both in the mouse vas deferens bioassay and in the opiate receptor binding assay.
Transcription (activity) of beta-endorphin in vas deferens associated with opiate and morphine
20) Confidence 0.53 Published 1977 Journal Can. J. Biochem. Section Abstract Doc Link 195688 Disease Relevance 0 Pain Relevance 0.27

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